静脉注射利多卡因对术后恶心呕吐影响的研究进展
Research Progress on the Effect of Intravenous Lidocaine for Postoperative Nausea and Vomiting
DOI: 10.12677/ACM.2024.142333, PDF,   
作者: 李 尧：右江民族医学院研究生学院，广西 百色；李朝标*：文山壮族苗族自治州人民医院麻醉科，云南 文山
关键词: 麻醉；利多卡因；术后恶心呕吐；术后恢复；Anesthesia； Lidocaine； Postoperative Nausea and Vomiting； Postoperative Recovery
摘要: 术后恶心呕吐(postoperative nausea and vomiting, PONV)是围术期常见的并发症之一，给患者造成了痛苦及经济损失，严重时还会危险生命安全。PONV的发生机制尚不明确，主要与患者易感性、手术和麻醉等危险因素有关，临床上多根据其危险因素进行预防，其预防手段包括药物预防和非药物预防，目前推荐多种药物联合或多模式预防。利多卡因是一种常用的局部麻醉药，静脉注射利多卡因最初主要用于心律失常的治疗，已有研究证明其可有效用于抗炎、镇痛、器官保护和促进胃肠道功能恢复等，大量研究表明其在PONV的预防中具有很大的潜力，可以作为单一用药、联合用药或多模式预防策略的一部分。
Abstract: Postoperative nausea and vomiting (PONV) is a prevalent and significant complication in the peri-operative period, inflicting discomfort and financial losses on patients, and in severe cases, posing a threat to their life safety. The pathogenesis of PONV is not fully understood but is primarily associ-ated with factors including patient susceptibility, surgical procedures, and anesthetic risks. Clini-cally, preventive measures are largely guided by these risk factors and include both pharmacologi-cal and non-pharmacological approaches. Current guidelines recommend a multimodal or com-bined pharmacological prevention strategy. Lidocaine, a commonly used local anesthetic, was first employed for the treatment of arrhythmias. And then research has confirmed its effects in an-ti-inflammatory, pain relief, organ protection, and gastrointestinal function recovery. Some previous studies revealed its potential in preventing PONV, advocating for its use as a standalone treatment, in combination with other medications, or as part of a multi-modal prevention strategy.
文章引用：李尧, 李朝标. 静脉注射利多卡因对术后恶心呕吐影响的研究进展[J]. 临床医学进展, 2024, 14(2): 2373-2382. https://doi.org/10.12677/ACM.2024.142333

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