氨甲环酸减少全髋关节置换围术期失血的研究进展
Research Progress on Reducing Perioperative Blood Loss in Total Hip Arthroplasty with Tranexamic Acid
摘要: 全髋关节置换术(THA)是髋关节终末期疾病的主要治疗手段，是骨科领域中常见的大型手术研究指出，THA手术过程中可能会因为创伤性操作而激活身体的纤溶系统，从而引发在手术过程和术后的一定程度的失血。近年来，大量研究表明氨甲环酸可有效降低全髋关节置换围术期失血量，在临床上，局部使用氨甲环酸也已经广泛实施。氨甲环酸作为一种抗纤溶剂，能防止由纤溶酶引发的纤维蛋白破坏，进而显著降低纤溶性，实现止血效果。本研究的目的在于总结氨甲环酸如何减THA手术期间出血的问题，以供医疗实践中作参考。
Abstract: Total hip arthroplasty (THA) is the main treatment for end-stage hip diseases and a common large-scale surgical study in the field of orthopedics. Research has shown that during THA surgery, the body’s fibrinolytic system may be activated due to traumatic procedures, leading to a certain degree of blood loss during and after the surgery. In recent years, a large number of studies have shown that tranexamic acid can effectively reduce perioperative blood loss in total hip replacement. In clinical practice, local use of tranexamic acid has also been widely implemented. As an antifibrot-ic solvent, tranexamic acid can prevent fibrin damage caused by plasmin, significantly reducing fi-brinolysis and achieving hemostatic effects. The purpose of this study is to summarize how tranexamic acid reduces bleeding during THA surgery, for reference in medical practice.
文章引用：胡超, 何佳靖, 张贵顺, 向明钧, 伍旭辉. 氨甲环酸减少全髋关节置换围术期失血的研究进展[J]. 临床医学进展, 2024, 14(2): 2383-2389. https://doi.org/10.12677/ACM.2024.142334

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