下肢深静脉血栓形成后综合征危险因素及预防策略的研究进展
Research Progress on Risk Factors and Preventive Strategies of Lower Extremity Post-Thrombotic Syndrome
摘要: 下肢深静脉血栓形成后综合征(post-thrombotic syndrome, PTS)是深静脉血栓形成(deep vein thrombosis, DVT)最常见的慢性并发症,可造成患者生活质量的严重下降。目前,早期识别PTS的高危患者并加以干预仍是临床关注的重点,但PTS相关的危险因素以及预防策略的实施细节仍有争议。本文对PTS的危险因素和预防策略进行了综述,以期为PTS预防体系构建提供借鉴,降低PTS发生率。
Abstract: Lower extremity post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), which can cause serious decline in patients’ quality of life. At present, early identification of patients at high risk of PTS and intervention remain the focus of clinical attention, but the risk factors for PTS and the implementation details of preventive strategies are still contro-versial. This article reviewed the risk factors and preventive strategies of PTS, in order to provide reference for the construction of PTS prevention system and reduce the incidence of PTS.
文章引用:徐叶亮. 下肢深静脉血栓形成后综合征危险因素及预防策略的研究进展[J]. 临床医学进展, 2024, 14(2): 2426-2433. https://doi.org/10.12677/ACM.2024.142340

参考文献

[1] Nawasrah, J., Zydek, B., Lucks, J., et al. (2021) Incidence and Severity of Postthrombotic Syndrome after Iliofemoral Thrombosis—Results of the Iliaca-PTS-Registry. VASA, 50, 30-37. [Google Scholar] [CrossRef] [PubMed]
[2] Broholm, R., Sillesen, H., Damsgaard, M.T., et al. (2011) Postthrombotic Syndrome and Quality of Life in Patients with Iliofemoral Venous Thrombosis Treated with Cathe-ter-Directed Thrombolysis. Journal of Vascular Surgery, 54, 18s-25s. [Google Scholar] [CrossRef] [PubMed]
[3] Grosse, S.D., Nelson, R.E., Nyarko, K.A., et al. (2016) The Eco-nomic Burden of Incident Venous Thromboembolism in the United States: A Review of Estimated Attributable Healthcare Costs. Thrombosis Research, 137, 3-10. [Google Scholar] [CrossRef] [PubMed]
[4] Sebastian, T., Spirk, D., Engelberger, R.P., et al. (2019) Inci-dence of Stent Thrombosis after Endovascular Treatment of Iliofemoral or Caval Veins in Patients with the Postthrom-botic Syndrome. Thrombosis and Haemostasis, 119, 2064-2073. [Google Scholar] [CrossRef] [PubMed]
[5] Rabinovich, A., Cohen, J.M., Prandoni, P., et al. (2014) Association between Thrombophilia and the Post-Thrombotic Syndrome: A Systematic Review and Meta-Analysis. Journal of Thrombosis and Haemostasis, 12, 14-23. [Google Scholar] [CrossRef] [PubMed]
[6] Yu, T., Song, J., Yu, L., et al. (2023) A Systematic Evaluation and Me-ta-Analysis of Early Prediction of Post-Thrombotic Syndrome. Frontiers in Cardiovascular Medicine, 10, Article ID: 1250480. [Google Scholar] [CrossRef] [PubMed]
[7] VisonÀ, A., Quere, I., Mazzolai, L., et al. (2021) Post-Thrombotic Syndrome. VASA, 50, 331-340. [Google Scholar] [CrossRef] [PubMed]
[8] 刘锋, 王仁鸿, 孙岩. 深静脉血栓形成置管溶栓术后发生重度血栓后综合征的危险因素分析及临床预测模型构建[J]. 中国现代普通外科进展, 2021, 24(12): 958-963.
[9] Kahn, S.R., Shrier, I., Julian, J.A., et al. (2008) Determinants and Time Course of the Postthrombotic Syndrome after Acute Deep Venous Thrombosis. Annals of Internal Medicine, 149, 698-707. [Google Scholar] [CrossRef] [PubMed]
[10] Tick, L.W., Doggen, C.J., Rosendaal, F.R., et al. (2010) Predictors of the Post-Thrombotic Syndrome with Non-Invasive Venous Examinations in Patients 6 Weeks after a First Episode of Deep Vein Thrombosis. Journal of Thrombosis and Haemostasis, 8, 2685-2692. [Google Scholar] [CrossRef] [PubMed]
[11] Stain, M., Schönauer, V., Minar, E., et al. (2005) The Post-Thrombotic Syndrome: Risk Factors and Impact on the Course of Thrombotic Disease. Journal of Thrombosis and Haemostasis, 3, 2671-2676. [Google Scholar] [CrossRef] [PubMed]
[12] Cowell, G.W., King, S.C., Reid, J.H., et al. (2016) Long-Term Adverse Effects Associated with Isolated Below-Knee Deep-Vein Thrombosis: A 10-Year Follow-Up Study. Clinical Radiology, 71, 369-374. [Google Scholar] [CrossRef] [PubMed]
[13] Rabinovich, A., Ducruet, T. and Kahn, S.R. (2018) Development of a Clinical Prediction Model for the Postthrombotic Syndrome in a Prospective Cohort of Patients with Proximal Deep Vein Thrombosis. Journal of Thrombosis and Haemostasis, 16, 262-270. [Google Scholar] [CrossRef] [PubMed]
[14] MÉAn, M., Limacher, A., Alatri, A., et al. (2018) Derivation and Validation of a Prediction Model for Risk Stratification of Post-Thrombotic Syndrome in Elderly Patients with a First Deep Vein Thrombosis. Thrombosis and Haemostasis, 118, 1419-1427. [Google Scholar] [CrossRef] [PubMed]
[15] 黄天安, 金泳海, 梁黎, 等. 下肢深静脉血栓形成后综合征风险列线图预测模型建立[J]. 介入放射学杂志, 2022, 31(1): 35-38.
[16] Galanaud, J.P., Holcroft, C.A., Rodger, M.A., et al. (2013) Predictors of Post-Thrombotic Syndrome in a Population with a First Deep Vein Thrombosis and No Primary Venous Insufficiency. Journal of Thrombosis and Haemostasis, 11, 474-480. [Google Scholar] [CrossRef] [PubMed]
[17] Nishimoto, Y., Yamashita, Y., Morimoto, T., et al. (2019) Risk Factors for Post-Thrombotic Syndrome in Patients with Deep Vein Thrombosis: From the COMMAND VTE Registry. Heart Vessels, 34, 669-677. [Google Scholar] [CrossRef] [PubMed]
[18] Wik, H.S., Jacobsen, A.F., Sandvik, L., et al. (2012) Prevalence and Predictors for Post-Thrombotic Syndrome 3 to 16 Years after Pregnancy-Related Venous Thrombosis: A Popula-tion-Based, Cross-Sectional, Case-Control Study. Journal of Thrombosis and Haemostasis, 10, 840-847. [Google Scholar] [CrossRef] [PubMed]
[19] Galanaud, J.P., Bertoletti, L., Amitrano, M., et al. (2018) Predictors of Post-Thrombotic Ulcer after Acute DVT: The RIETE Registry. Thrombosis and Haemostasis, 118, 320-328. [Google Scholar] [CrossRef
[20] Agrawal, V. and Kim, E.S.H. (2019) Risk of Recurrent Ve-nous Thromboembolism after an Initial Episode: Risk Stratification and Implications for Long-Term Treatment. Current Cardiology Reports, 21, Article No. 24. [Google Scholar] [CrossRef] [PubMed]
[21] Amin, E.E., Bistervels, I.M., Meijer, K., et al. (2018) Reduced In-cidence of Vein Occlusion and Postthrombotic Syndrome after Immediate Compression for Deep Vein Thrombosis. Blood, 132, 2298-2304. [Google Scholar] [CrossRef] [PubMed]
[22] Dronkers, C.E.A., Mol, G.C., Maraziti, G., et al. (2018) Pre-dicting Post-Thrombotic Syndrome with Ultrasonographic Follow-Up after Deep Vein Thrombosis: A Systematic Re-view and Meta-Analysis. Thrombosis and Haemostasis, 118, 1428-1438. [Google Scholar] [CrossRef] [PubMed]
[23] Huang, H., Gu, J.P., Shi, H.F., et al. (2018) Assessment of the Probability of Post-Thrombotic Syndrome in Patients with Lower Extremity Deep Venous Thrombosis. Scientific Reports, 8, Article No. 12663. [Google Scholar] [CrossRef] [PubMed]
[24] Iding, A.F.J., Kremers, B.M.M., Pallares Robles, A., et al. (2023) Residual Venous Obstruction as an Indicator of Clinical Outcomes Following Deep Vein Thrombosis: A Man-agement Study. Thrombosis and Haemostasis, 123, 763- 772. [Google Scholar] [CrossRef] [PubMed]
[25] Fox, M.A. and Kahn, S.R. (2008) Postthrombotic Syndrome in Relation to Vena Cava Filter Placement: A Systematic Review. Journal of Vascular and Interventional Radiology, 19, 981-985. [Google Scholar] [CrossRef] [PubMed]
[26] Ferreira, T., Huber, S.C., De Moraes Martinelli, B., et al. (2020) Low Prevalence of Post-Thrombotic Syndrome in Patients Treated with Rivaroxaban. Vascular Pharmacology, 124, Ar-ticle ID: 106608. [Google Scholar] [CrossRef] [PubMed]
[27] Li, R., Yuan, M., Cheng, J., et al. (2020) Risk of Post-Thrombotic Syndrome after Deep Vein Thrombosis Treated with Rivaroxaban versus Vitamin-K Antagonists: A Systematic Review and Meta-Analysis. Thrombosis Research, 196, 340- 348. [Google Scholar] [CrossRef] [PubMed]
[28] Chitsike, R.S., Rodger, M.A., Kovacs, M.J., et al. (2012) Risk of Post-Thrombotic Syndrome after Subtherapeutic Warfarin Anticoagulation for a First Unprovoked Deep Vein Thrombosis: Results from the REVERSE Study. Journal of Thrombosis and Haemostasis, 10, 2039-2044. [Google Scholar] [CrossRef] [PubMed]
[29] Labropoulos, N., Gasparis, A.P. and Tassiopoulos, A.K. (2009) Prospective Evaluation of the Clinical Deterioration in Post-Thrombotic Limbs. Journal of Vascular Surgery, 50, 826-830. [Google Scholar] [CrossRef] [PubMed]
[30] Wik, H.S., Jacobsen, A.F., Mowinckel, M.C., et al. (2016) The Role of Inflammation in Post-Thrombotic Syndrome after Pregnancy-Related Deep Vein Thrombosis: A Popula-tion-Based, Cross-Sectional Study. Thrombosis Research, 138, 16-21. [Google Scholar] [CrossRef] [PubMed]
[31] McLeod, B., Lim, H.Y., Nandurkar, H., et al. (2022) Overall Hemostatic Potential Assay Detects Risk of Progression to Post-Thrombotic Syndrome in Anticoagulated Patients Fol-lowing Deep Vein Thrombosis. Diagnostics (Basel), 12, Article No. 3165. [Google Scholar] [CrossRef] [PubMed]
[32] Mrozinska, S., Cieslik, J., Broniatowska, E., et al. (2018) Ele-vated Leptin and Decreased Adiponectin Independently Predict the Post-Thrombotic Syndrome in Obese and Non-Obese Patients. Scientific Reports, 8, Article No. 6938. [Google Scholar] [CrossRef] [PubMed]
[33] Potere, N., Abbate, A., Kanthi, Y., et al. (2023) Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism. JACC: Basic to Translational Science, 8, 1245-1261. [Google Scholar] [CrossRef] [PubMed]
[34] Rabinovich, A., Cohen, J.M. and Kahn, S.R. (2015) Predictive Value of Markers of Inflammation in the Postthrombotic Syndrome: A Systematic Review: Inflammatory Biomarkers and PTS. Thrombosis Research, 136, 289-297. [Google Scholar] [CrossRef] [PubMed]
[35] De Franciscis, S., Gallelli, L., Amato, B., et al. (2016) Plasma MMP and TIMP Evaluation in Patients with Deep Venous Thrombosis: Could They Have a Predictive Role in the De-velopment of Post-Thrombotic Syndrome? International Wound Journal, 13, 1237-1245. [Google Scholar] [CrossRef] [PubMed]
[36] Rabinovich, A., Cohen, J.M. and Kahn, S.R. (2014) The Predictive Value of Markers of Fibrinolysis and Endothelial Dysfunction in the Post Thrombotic Syndrome. A Systematic Review. Throm-bosis and Haemostasis, 111, 1031-1040. [Google Scholar] [CrossRef
[37] Siudut, J., Grela, M., Wypasek, E., et al. (2016) Reduced Plasma Fi-brin Clot Permeability and Susceptibility to Lysis Are Associated with Increased Risk of Postthrombotic Syndrome. Journal of Thrombosis and Haemostasis, 14, 784-793. [Google Scholar] [CrossRef] [PubMed]
[38] Bittar, L.F., Silva, L.Q.D., Orsi, F.L.A., et al. (2020) Increased Inflammation and Endothelial Markers in Patients with Late Severe Post-Thrombotic Syndrome. PLOS ONE, 15, E0227150. [Google Scholar] [CrossRef] [PubMed]
[39] Makedonov, I., Kahn, S.R., Abdulrehman, J., et al. (2022) Pre-vention of the Postthrombotic Syndrome with Anticoagulation: A Narrative Review. Thrombosis and Haemostasis, 122, 1255-1264. [Google Scholar] [CrossRef] [PubMed]
[40] Bradbury, C., Fletcher, K., Sun, Y., et al. (2020) A Ran-domised Controlled Trial of Extended Anticoagulation Treatment versus Standard Treatment for the Prevention of Recur-rent Venous Thromboembolism (VTE) and Post-Throm- botic Syndrome in Patients Being Treated for a First Episode of Unprovoked VTE (The ExACT Study). British Journal of Haematology, 188, 962-975. [Google Scholar] [CrossRef] [PubMed]
[41] Haig, Y., Enden, T., Grøtta, O., et al. (2016) Post-Thrombotic Syndrome after Catheter-Directed Thrombolysis for Deep Vein Thrombosis (CaVenT): 5-Year Follow-Up Results of an Open-Label, Randomised Controlled Trial. The Lancet Haematology, 3, E64-E71. [Google Scholar] [CrossRef
[42] Sharifi, M., Bay, C., Mehdipour, M., et al. (2012) Thrombus Obliteration by Rapid Percutaneous Endovenous Intervention in Deep Venous Occlusion (TORPEDO) Trial: Midterm Results. Journal of Endovascular Therapy, 19, 273-280. [Google Scholar] [CrossRef
[43] Vedantham, S., Goldhaber, S.Z., Julian, J.A., et al. (2017) Pharma-comechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis. The New England Journal of Medicine, 377, 2240-2252. [Google Scholar] [CrossRef
[44] Pompilio, G., Monreal, M., Pesavento, R., et al. (2022) Me-ta-Analyses of Sulodexide and Other Drugs in Prevention and Treatment of Post-Thrombotic Syndrome. European Re-view for Medical and Pharmacological Sciences, 26, 9372- 9381.
[45] Caiano, L.M., Drury, T., Zahrai, A., et al. (2023) Role of Statins in the Prevention of Post-Thrombotic Syndrome after a Deep Vein Thrombosis Event: A Systematic Re-view and Meta-Analysis. Journal of Thrombosis and Haemostasis, 21, 944-952. [Google Scholar] [CrossRef] [PubMed]
[46] Morling, J.R., Yeoh, S.E. and Kolbach, D.N. (2018) Rutosides for Prevention of Post-Thrombotic Syndrome. The Cochrane Database of Systematic Reviews, 11, Cd005626. [Google Scholar] [CrossRef
[47] Skervin, A.L., Thapar, A., Franchini, A.J., et al. (2016) Systematic Review and Meta-Analysis of Utility of Graduated Compression Stockings in Prevention of Post-Thrombotic Syndrome. European Journal of Vascular and Endovascular Surgery, 51, 838-845. [Google Scholar] [CrossRef] [PubMed]
[48] Galanaud, J.P., Genty-Vermorel, C., Rolland, C., et al. (2020) Compression Stockings to Prevent Postthrombotic Syndrome: Literature Overview and Presentation of the CELEST Trial. Research and Practice in Thrombosis and Haemostasis, 4, 1239-1250. [Google Scholar] [CrossRef] [PubMed]
[49] Appelen, D., Van Loo, E., Prins, M.H., et al. (2017) Compression Therapy for Prevention of Post-Thrombotic Syndrome. The Cochrane Database of Systematic Reviews, 9, CD004174. [Google Scholar] [CrossRef
[50] Kahn, S.R., Shapiro, S., Wells, P.S., et al. (2014) Com-pression Stockings to Prevent Post-Thrombotic Syndrome: A Randomised Placebo-Controlled Trial. The Lancet, 383, 880-888. [Google Scholar] [CrossRef
[51] Mol, G.C., Van De Ree, M.A., Klok, F.A., et al. (2016) One versus Two Years of Elastic Compression Stockings for Prevention of Post-Thrombotic Syndrome (OCTAVIA Study): Randomised Controlled Trial. BMJ, 353, I2691. [Google Scholar] [CrossRef] [PubMed]
[52] Jasionowska, S., Turner, B.R.H., Machin, M., et al. (2022) Systematic Re-view of Exercise Therapy in the Management of Post-Thrombotic Syndrome. Phlebology, 37, 695-700. [Google Scholar] [CrossRef] [PubMed]