骨纤维结构不良的临床研究进展

Progress in Clinical Research of Osteofibrous Dysplasia

摘要: 骨纤维结构不良是主要累及儿童胫骨的良性肿瘤。其发病率低，目前对该病认识不足，误诊率高。主要表现为局部肿块。典型的影像学表现为局限于胫骨中段前侧皮质内，单房性或多房性、偏心性、界限清楚的低密度灶。但目前其病因、治疗方式及治疗时机尚未达成普遍共识，现对该病的病因和发病机制、临床表现、影像学表现、诊断及鉴别诊断、治疗展开综述。

Abstract: Osteofibrous dysplasia is a benign tumor primarily affecting the tibia in pediatric patients. Its inci-dence is relatively low, and there remains an inadequate understanding of the disease, leading to a high rate of misdiagnosis. The main clinical manifestation is the presence of a localized mass. Typi-cal imaging findings consist of unilocular or multilocular, eccentric, well-defined low-density lesions confined to the medial anterior cortex of the tibia. However, currently there is no consensus re-garding its etiology, treatment approach, and optimal timing for intervention. This review aims to explore the etiology and pathogenesis, clinical presentation, imaging features, diagnostic methods as well as differential diagnosis and treatment options for this condition.