2型糖尿病相关肌少症发病机制的研究进展
Research Progress on Pathogenesis of Type 2 Diabetes-Related Sarcopenia
DOI: 10.12677/ACM.2024.142350, PDF,   
作者: 孙 靓, 樊 勇*:新疆医科大学第一附属医院内分泌科,新疆 乌鲁木齐
关键词: 2型糖尿病肌少症发病机制Type 2 Diabetes Sarcopenia Pathogenesis
摘要: 肌少症是一种伴随着年龄的增长而发生的以肌肉量减少、肌力下降和肌功能减退为主要特征的退行性病变。肌少症通常与衰老有关,但是,像T2DM这样的慢性疾病可以加速肌肉的消耗,从而导致肌少症。T2DM相关肌少症可能的病因包括胰岛素抵抗、炎症反应、脂质沉积、氧化应激与线粒体损伤及糖尿病相关并发症等。本文主要探讨目前2型糖尿病相关性肌少症的可能发病机制。
Abstract: Sarcopenia is a degenerative disease that occurs with the growth of age and is mainly characterized by decreased muscle mass, decreased muscle strength and decreased muscle function. Sarcopenia is often associated with aging; however, chronic diseases like T2DM can accelerate muscle wasting, which can lead to sarcopenia. Possible causes of T2DM related sarcopenia include insulin resistance, inflammatory response, lipid deposition, oxidative stress and mitochondrial damage, and diabe-tes-related complications. This paper aims to explore the possible pathogenesis of sarcopenia asso-ciated with type 2 diabetes mellitus.
文章引用:孙靓, 樊勇. 2型糖尿病相关肌少症发病机制的研究进展[J]. 临床医学进展, 2024, 14(2): 2496-2501. https://doi.org/10.12677/ACM.2024.142350

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