内皮糖蕚在急性胰腺炎所致凝血功能障碍中的机制研究

Mechanisms of Endothelial Glycocalyx in Coagulation Abnormalities Due to Acute Pancreatitis

摘要: 急性胰腺炎(acute pancreatitis, AP)是一种常见的严重程度不等的炎症性疾病，从轻微的局部炎症到全身受累，炎症反应和凝血功能障碍贯穿始终，相互促进，并深刻影响着AP患者的治疗和预后。越来越多的研究表明凝血异常与该疾病的严重程度密切相关，而内皮糖萼作为抵抗内皮损伤的第一道防线，在维持凝血和抗凝之间的微妙平衡起着至关重要的作用。因此本综述旨在总结以下内容：1) 内皮糖萼的结构和功能，2) 它在AP所导致的凝血功能障碍中的潜在作用，以及3) 总结基于内皮糖蕚的保护机制，优化AP的治疗方案。

Abstract: Acute pancreatitis (AP) is a common inflammatory disease of varying severity, ranging from mild local inflammation to systemic involvement, with inflammation and coagulation abnormalities con-tributing to each other throughout and profoundly affecting the therapeutic process and prognosis of AP patients. A growing number of studies have shown that coagulation abnormalities are strongly correlated with the severity of the disease and that the endothelial glycocalyx, the first line of de-fense against endothelial injury, plays a vital role in maintaining the delicate balance between blood coagulation and anticoagulation. Therefore, this review aims to summarize: 1) the structure and function of the endothelial glycocalyx, 2) its potential role in the coagulation abnormalities caused by AP, and 3) to summarize the protective mechanisms based on the endothelial glycocalyx to optimize the therapeutic regimen for AP.