颅底脊索瘤放射治疗
Radiotherapy for Chordoma of Skull Base
DOI: 10.12677/ACM.2024.142377, PDF,    科研立项经费支持
作者: 张云波, 李沐阳, 张建光*:淄博万杰肿瘤医院肿瘤科,山东 淄博;郑丽萍:淄博万杰肿瘤医院心血管内二科,山东 淄博;赵允正:阳光融和医院放疗科,山东 潍坊;李锦秋:河北北方学院附属第一医院放疗科,河北 张家口
关键词: 颅底脊索瘤放疗质子治疗碳离子放射治疗Chordoma of Skull Base Radiotherapy Proton Therapy Carbon Ion Radiotherapy
摘要: 颅底脊索瘤为少见肿瘤之一,生长缓慢,但具有高的复发倾向。手术是主要治疗手段,由于局部解剖结构影响,手术受到一定限制。通常采取手术后放疗或根治性放疗。随着放疗技术提高,立体定向放疗、调强治疗、质子治疗和碳离子治疗应用越来越广泛。不同放疗技术对生存影响和不良反应也存在差异。本文对颅底脊索瘤放疗的现状进行了综述。
Abstract: Chordoma of skull base is one of the rare tumors with slow growth but high recurrence tendency. Surgery is the main method of treatment. Due to the influence of local anatomical structure, surgery is limited, usually taking postoperative radiotherapy or radical radiotherapy. With the improve-ment of radiotherapy technology, stereotactic radiotherapy, intensity modulated therapy, proton therapy and carbon ion radiotherapy are more and more widely used. Different radiotherapy tech-niques also have different effects on survival and adverse reactions. In this paper, the current status of radiotherapy for chordoma of skull base is reviewed.
文章引用:张云波, 郑丽萍, 李沐阳, 赵允正, 李锦秋, 张建光. 颅底脊索瘤放射治疗[J]. 临床医学进展, 2024, 14(2): 2680-2685. https://doi.org/10.12677/ACM.2024.142377

参考文献

[1] Ulici, V. and Hart, J. (2022) Chordoma. Archives of Pathology & Laboratory Medicine, 146, 386-395. [Google Scholar] [CrossRef
[2] Wasserman, J.K., Gravel, D. and Purgina, B. (2018) Chordoma of the Head and Neck: A Review. Head and Neck Pathology, 12, 261-268. [Google Scholar] [CrossRef] [PubMed]
[3] Karele, E.N. and Paze, A.N. (2022) Chordoma: To Know Means to Recognize. Biochimica et Biophysica Acta (BBA)—Reviews on Cancer, 1877, Article ID: 188796. [Google Scholar] [CrossRef] [PubMed]
[4] Kano, H., Niranjan, A. and Lunsford, L.D. (2019) Radiosurgery for Chordoma and Chondrosarcoma. Progress in Neurological Surgery, 34, 207-214. [Google Scholar] [CrossRef] [PubMed]
[5] Imai, R., Kamada, T., Tsuji, H., Yanagi, T., Baba, M., Miyamoto, T., et al. (2004) Carbon Ion Radiotherapy for Unresectable Sacral Chordomas. Clinical Cancer Research, 10, 5741-5746. [Google Scholar] [CrossRef
[6] Kremenevski, N., Schlaffer, S.M., Coras, R., Kinfe, T.M., Graillon, T. and Buchfelder, M. (2020) Skull Base Chordomas and Chondrosarcomas. Neuroendocrinology, 110, 836-847. [Google Scholar] [CrossRef] [PubMed]
[7] Stacchiotti, S. and Sommer, J. (2015) Building a Global Con-sensus Approach to Chordoma: A Position Paper from Themedical and Patient Community. The Lancet Oncology, 16, e71-e83. [Google Scholar] [CrossRef
[8] Passer, J.Z., Alvarez-Breckenridge, C., Rhines, L., DeMonte, F., Tatsui, C. and Raza, S.M. (2021) Surgical Management of Skull Base and Spine Chordomas. Current Treatment Op-tions in Oncology, 22, Article No. 40. [Google Scholar] [CrossRef] [PubMed]
[9] Choy, W., Terterov, S., Kaprealian, T.B., et al. (2015) Predictors of Recurrence Following Resection of Intracranial Chordomas. Journal of Clinical Neuroscience, 22, 1792-1796. [Google Scholar] [CrossRef] [PubMed]
[10] Rotondo, R.L., Folkert, W., Liebsch, N.J., et al. (2015) High-Dose Proton-Based Recent Advances in Understanding and Managing Chordomas: An Update Radiation Therapy in the Man-agement of Spine Chordomas: Outcomes and Clinicopathological Prognostic Factors. Journal of Neurosurgery: Spine, 23, 788-797. [Google Scholar] [CrossRef
[11] Combs, S.E., Baumert, B.G., Bendszus, M., Bozzao, A., Brada, M., Fariselli, L., Fiorentino, A., Ganswindt, U., Grosu, A.L., Lagerwaard, F.L., Niyazi, M., Nyholm, T., Paddick, I., Weber, D.C., Belka, C. and Minniti, G. (2021) ESTRO ACROP Guideline for Target Volume Delineation of Skull Base Tumors. Radiotherapy and Oncology, 156, 80-94. [Google Scholar] [CrossRef] [PubMed]
[12] Mercado, C.E., Holtzman, A.L., Rotondo, R., Rutenberg, M.S. and Mendenhall, W.M. (2019) Proton Therapy for Skull Base Tumors: A Review of Clinical Outcomes for Chordomas and Chondrosarcomas. Head & Neck, 41, 536-541. [Google Scholar] [CrossRef] [PubMed]
[13] Trifiletti, D.M. and Brown, P.D. (2020) Proton and Carbon Ion Therapy for Skull Base Chordomas. Neuro-Oncology, 22, 1241-1242. [Google Scholar] [CrossRef] [PubMed]
[14] Takagi, M., Demizu, Y., Nagano, F., Terashima, K., Fujii, O., Jin, D., Mima, M., Niwa, Y., Katsui, K., Suga, M., Yamashita, T., Akagi, T., Sakata, K.I., Fuwa, N. and Okimoto, T. (2018) Treatment Outcomes of Proton or Carbon Ion Therapy for Skull Base Chordoma: A Retrospective Study. Radiation Oncology, 13, Article No. 232. [Google Scholar] [CrossRef] [PubMed]
[15] Yaniv, D., Soudry, E., Strenov, Y., Cohen, M.A. and Mizrachi, A. (2020) Skull Base Chordomas Review of Current Treatment Paradigms. World Journal of Otorhinolaryngology—Head and Neck Surgery, 6, 125-131. [Google Scholar] [CrossRef] [PubMed]
[16] Rich, T.A., Schiller, A., Suit, H.D. and Mankin, H.J. (1985) Clin-ical and Pathologic Review of 48 Cases of Chordoma. Cancer, 56, 182-187. [Google Scholar] [CrossRef
[17] Fossati, P., Vavassori, A., Deantonio, L., Ferrara, E., Krengli, M. and Orecchia, R. (2016) Review of Photon and Proton Radiother-apy for Skull Base Tumours. Reports of Practical Oncology and Radiotherapy, 21, 336-355. [Google Scholar] [CrossRef] [PubMed]
[18] Krishnan, S., Foote, R.L., Brown, P.D., Pollock, B.E., Link, M.J. and Garces, Y.I. (2005) Radiosurgery for Cranial Base Chordomas and Chondrosarcomas. Neurosurgery, 56, 777-784. [Google Scholar] [CrossRef
[19] Debus, J., Schulz-Ertner, D., Schad, L., Essig, M., Rhein, B., Thillmann, C.O. and Wannenmacher, M. (2000) Stereotactic Fractionated Radiotherapy for Chordomas and Chondrosarcomas of the Skull Base. International Journal of Radiation Oncology, Biology, Physics, 47, 591-596. [Google Scholar] [CrossRef
[20] Sahgal, A., Chan, M.W., Atenafu, E.G., Masson-Cote, L., Bahl, G., Yu, E., Millar, B.A., Chung, C., Catton, C., O’Sullivan, B., Irish, J.C., Gilbert, R., Zadeh, G., Cusimano, M., Gentili, F. and Laperriere, N.J. (2015) Image-Guided, Intensity-Modulated Radiation Therapy (IG-IMRT) for Skull Base Chordoma and Chondrosarcoma: Preliminary Outcomes. Neuro-Oncology, 17, 889-894. [Google Scholar] [CrossRef] [PubMed]
[21] Martin, J.J., Niranjan, A., Kondziolka, D., Flickinger, J.C., Lozanne, K.A. and Lunsford, L.D. (2007) Radiosurgery for Chordomas and Chondrosarcomas of the Skull Base. Journal of Neu-rosurgery, 107, 758-764. [Google Scholar] [CrossRef
[22] Evans, L.T., DeMonte, F., Grosshans, D.R., Ghia, A.J., Habib, A. and Raza, S.M. (2020) Salvage Therapy for Local Progression Following Definitive Therapy for Skull Base Chordomas: Is There a Role of Stereotactic Radiosurgery? Journal of Neurological Surgery Part B: Skull Base, 81, 97-106. [Google Scholar] [CrossRef] [PubMed]
[23] Nakamura, N., Zenda, S., Tahara, M., Okano, S., Hayashi, R., Hojo, H., Hotta, K., Kito, S., Motegi, A., Arahira, S., Tachibana, H. and Akimoto, T. (2017) Proton Beam Therapy for Olfac-tory Neuroblastoma. Radiotherapy and Oncology, 122, 368-372. [Google Scholar] [CrossRef] [PubMed]
[24] Catton, C., O’Sullivan, B., Bell, R., Laperriere, N., Cummings, B., Fornasier, V. and Wunder, J. (1996) Chordoma: Long-Term Follow-Up after Radical Photon Irradiation. Radiother-apy and Oncology, 41, 67-72. [Google Scholar] [CrossRef
[25] Hug, E.B. and Slater, J.D. (2000) Proton Radiation Therapy for Chordomas and Chondrosarcomas of the Skull Base. Neurosurgery Clinics of North America, 11, 627-638. [Google Scholar] [CrossRef
[26] Hayashi, Y., Mizumoto, M., Akutsu, H., Takano, S., Matsumura, A., Okumura, T., Kawabe, T., Zenkoh, J., Sakurai, H. and Tsuboi, K. (2016) Hyperfractionated High-Dose Proton Beam Radiotherapy for Clival Chordomas after Surgical Removal. The British Journal of Radiology, 89, Article ID: 20151051. [Google Scholar] [CrossRef] [PubMed]
[27] Uhl, M., Mattke, M., Welzel, T., Roeder, F., Oelmann, J., Habl, G., Jensen, A., Ellerbrock, M., Jäkel, O., Haberer, T., Herfarth, K. and Debus, J. (2014) Highly Effective Treat-ment of Skull Base Chordoma with Carbon Ion Irradiation Using a Raster Scan Technique in 155 Patients: First Long-Term Results. Cancer, 120, 3410-3417. [Google Scholar] [CrossRef] [PubMed]
[28] Iannalfi, A., D’Ippolito, E., Riva, G., Molinelli, S., Gandini, S., Viselner, G., Fiore, M.R., Vischioni, B., Vitolo, V., Bonora, M., Ronchi, S., Petrucci, R., Barcellini, A., Mirandola, A., Russo, S., Vai, A., Mastella, E., Magro, G., Maestri, D., Ciocca, M., Preda, L., Valvo, F. and Orecchia, R. (2020) Proton and Car-bon Ion Radiotherapy in Skull Base Chordomas: A Prospective Study Based on a Dual Particle and a Patient-Customized Treatment Strategy. Neuro-Oncology, 22, 1348-1358. [Google Scholar] [CrossRef] [PubMed]
[29] Zhou, J., Yang, B., Wang, X. and Jing, Z. (2018) Comparison of the Effectiveness of Radiotherapy with Photons and Particles for Chor-doma after Surgery: A Meta-Analysis. World Neurosurgery, 117, 46-53. [Google Scholar] [CrossRef] [PubMed]
[30] Connors, S.W., Aoun, S.G., Shi, C., Peinado-Reyes, V., Hall, K. and Bagley, C.A. (2020) Recent Advances in Understanding and Managing Chordomas: An Update. F1000Research, 9, 713. [Google Scholar] [CrossRef] [PubMed]
[31] Freeman, J.L., Kaufmann, A.B., Everson, R.G., DeMonte, F. and Raza, S.M. (2019) Evidence-Based Optimization of Post-Treatment Surveillance for Skull Base Chordomas Based on Local and Distant Disease Progression. Operative Neurosurgery (Hagerstown), 16, 27-36. [Google Scholar] [CrossRef] [PubMed]
[32] Raza, S.M., Bell, D., Freeman, J.L., Grosshans, D.R., Fuller, G.N. and DeMonte, F. (2018) Multimodality Management of Recurrent Skull Base Chordomas: Factors Impacting Tumor Control and Disease-Specific Survival. Operative Neurosurgery (Hagerstown), 15, 131-143. [Google Scholar] [CrossRef] [PubMed]
[33] Stacchiotti, S., Gronchi, A., Fossati, P., Akiyama, T., Alapetite, C., Bau-mann, M., Blay, J.Y., Bolle, S., Boriani, S., Bruzzi, P., Capanna, R., Caraceni, A., Casadei, R., Colia, V., Debus, J., Delaney, T., Desai, A., Dileo, P., Dijkstra, S., Doglietto, F., Flanagan, A., Froelich, S., Gardner, PA., Gelderblom, H., Gokaslan, Z.L., Haas, R., Heery, C., Hindi, N., Hohenberger, P., Hornicek, F., Imai, R., Jeys, L., Jones, RL., Kasper, B., Kawai, A., Krengli, M., Leithner, A., Logowska, I., Martin, Broto, J., Mazzatenta, D., Morosi, C., Nicolai, P., Norum, O.J., Patel, S., Penel, N., Picci, P., Pilotti, S., Radaelli, S., Ricchini, F., Rutkowski, P., Scheipl, S., Sen, C., Tamborini, E., Thornton, K.A., Timmermann, B., Torri, V., Tunn, P.U., Uhl, M., Yamada, Y., Weber, D.C., Vanel, D., Varga, P.P., Vleggeert-Lankamp, C.L.A., Casali, P.G. and Sommer, J. (2017) Best Practices for the Management of Local-Regional Recurrent Chordoma: A Position Paper by the Chordoma Global Consensus Group. Annals of Oncology, 28, 1230-1242. [Google Scholar] [CrossRef] [PubMed]
[34] Alahmari, M. and Temel, Y. (2019) Skull Base Chordoma Treated with Proton Therapy: A Systematic Review. Surgical Neurology International, 10, Article No. 96. [Google Scholar] [CrossRef
[35] Morimoto, Y., Tamura, R., Ohara, K., Kosugi, K., Oishi, Y., Kuranari, Y., Yoshida, K. and Toda, M. (2019) Prognostic Significance of VEGF Receptors Expression on the Tumor Cells in Skull Base Chordoma. Journal of Neuro-Oncology, 144, 65-77. [Google Scholar] [CrossRef] [PubMed]
[36] Guan, X., Gao, J., Hu, J., Hu, W., Yang, J., Qiu, X., Hu, C., Kong, L. and Lu, J.J. (2019) The Preliminary Results of Proton and Carbon Ion Therapy for Chordoma and Chondro-sarcoma of the Skull Base and Cervical Spine. Radiation Oncology, 14, Article No. 206. [Google Scholar] [CrossRef] [PubMed]
[37] Gatfield, E.R., Noble, D.J., Barnett, G.C., Early, N.Y., Hoole, A.C.F., Kirkby, N.F., Jefferies, S.J. and Burnet, N.G. (2018) Tumour Volume and Dose Influence Outcome after Sur-gery and High-Dose Photon Radiotherapy for Chordoma and Chondrosarcoma of the Skull Base and Spine. Clinical Oncology, 30, 243-253. [Google Scholar] [CrossRef] [PubMed]
[38] Zhou, J., Jiang, Y., Zhang, H., Chen, L., Luo, P., Li, L., Zhao, J., Lv, F., Zou, D., Zhang, Y. and Jing, Z. (2019) Clinicopathological Implications of TIM3+ Tumor-Infiltrating Lympho-cytes and the MiR-455-5p/Galectin-9 Axis in Skull Base Chordoma Patients. Cancer Immunology, Immunotherapy, 68, 1157-1169. [Google Scholar] [CrossRef] [PubMed]