免疫检查点抑制剂相关内分泌不良反应的临床研究进展
Research Advances of Immune Checkpoint Inhibitors Related Endocrine Adverse Events
DOI: 10.12677/ACM.2024.142381, PDF,   
作者: 王晶晶, 郑芬萍*:浙江大学医学院附属邵逸夫医院内分泌科,浙江 杭州
关键词: 免疫检查点抑制剂免疫相关不良反应内分泌病Immune Checkpoint Inhibitors Immune-Related Adverse Events Endocrinopathy
摘要: 免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)通过阻断免疫抑制、增强机体免疫实现抗肿瘤效应,显著提高了恶性肿瘤的生存率。ICIs在抗肿瘤的同时也会产生免疫相关不良反应(immune-related adverse events, irAEs),内分泌irAEs是其中最常见的,可以累及到垂体、甲状腺、胰腺、肾上腺等。虽然内分泌irAEs通常不严重,但是也会发生危及生命的内分泌急症以及罕见的内分泌病变,因此需要得到临床的重视。目前内分泌irAEs的机制尚无定论,本文就其发病率、发病机制、临床表现、治疗作一综述。
Abstract: Immune checkpoint inhibitors (ICIs) can enhance the anti-tumor effect by blocking immunosup-pression and strengthening the body’s immunity, which has significantly improved the survival rate of malignant tumors. However, ICIs can cause immune adverse events (irAEs) at the same time, and endocrine irAEs are the most common events and can involve the pituitary, thyroid, pancreas, ad-renal glands, etc. Although endocrine irAEs are not serious generally, life-threatening endocrine emergencies as well as rare endocrinopathies can occur. Therefore, the events require clinical at-tention. The mechanism of endocrine irAEs is still inconclusive, and this article provides an over-view of their incidence, pathogenesis, clinical manifestations, and treatment.
文章引用:王晶晶, 郑芬萍. 免疫检查点抑制剂相关内分泌不良反应的临床研究进展[J]. 临床医学进展, 2024, 14(2): 2706-2716. https://doi.org/10.12677/ACM.2024.142381

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