动脉粥样硬化及栓塞所致急性颅内大血管闭塞病因研究进展
Research Progress on the Causes of Acute Intracranial Large Vessel Occlusion Caused by Atherosclerosis and Embolism
DOI: 10.12677/ACM.2024.142404, PDF,   
作者: 王智鹏, 吴 伟：吉首大学医学院，湖南 吉首；张家界市人民医院神经外科，湖南 张家界；蒋章亮：张家界市人民医院神经外科，湖南 张家界；秧茂盛：吉首大学药学院，湖南 吉首
关键词: 颅内大血管闭塞；颅内动脉粥样硬化性闭塞；栓塞性闭塞；Intracranial Large Vessel Occlusion； Intracranial Atherosclerotic Disease Occlusions； Embolic Occlusion
摘要: 卒中是严重危害中国国民健康的重大慢性非传染性疾病，是我国成人致死、致残的首位病因，目前机械取栓已经成为我国急性大血管闭塞卒中病人的首选治疗方案之一，然而，不同病因所致的颅内大血管闭塞患者的治疗方案及预后有所不同，如何区分不同病因所致的急性颅内大血管闭塞仍然没有一个定论。因此，本文将对近年来动脉粥样硬化及栓塞所致的急性颅内大血管闭塞病因研究进展进行综述，以期为临床实践提供更多参考。
Abstract: Stroke is a serious harm to Chinese national health major chronic noncommunicable diseases, is the first cause of adult death and disability, the mechanical thrombolysis has become one of the pre-ferred treatment of acute large vessel occlusion stroke patients in China; however, different causes of intracranial large vessel occlusion treatment and different prognosis, how to distinguish different causes of acute intracranial large vessel occlusion is still not a conclusion, therefore, this paper will in recent years of atherosclerosis and embolism caused by acute intracranial large vessel occlusion etiology progress in the review, in order to provide more reference for clinical practice.
文章引用：王智鹏, 吴伟, 蒋章亮, 秧茂盛. 动脉粥样硬化及栓塞所致急性颅内大血管闭塞病因研究进展[J]. 临床医学进展, 2024, 14(2): 2859-2865. https://doi.org/10.12677/ACM.2024.142404

参考文献

[1] 《中国脑卒中防治报告2021》概要[J]. 中国脑血管病杂志, 2023, 20(11): 783-793.
[2] GBD 2019 Stroke Col-laborators (2021) Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990- 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. Lancet Neurology, 20, 795-820.
[3] Chen, Y., Wright, N., Guo, Y., et al. (2020) Mortality and Recurrent Vascular Events after First Incident Stroke: A 9-Year Community-Based Study of 0∙5 Million Chinese Adults. The Lancet Global Health, 8, E580-E590. [Google Scholar] [CrossRef] 
[4] 国家卫生健康委员会. 中国卫生健康统计年鉴2020[M]. 北京: 中国协和医科大学出版社, 2020: 279-295.
[5] Wang, W., Jiang, B., Sun, H., et al. (2017) Prevalence, Inci-dence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480 687 Adults. Cir-culation, 135, 759-771. [Google Scholar] [CrossRef] 
[6] Rai, A.T., Seldon, A.E., Boo, S., et al. (2017) A Population-Based Incidence of Acute Large Vessel Occlusions and Thrombectomy Eligible Patients Indicates Significant Potential for Growth of Endovascular Stroke Therapy in the USA. Journal of NeuroInterventional Surgery, 9, 722-726. [Google Scholar] [CrossRef] [PubMed]
[7] 吴泳, 钟望涛, 黄汉宁. 急性大动脉闭塞性脑梗死研究进展[J]. 中国实用神经疾病杂志, 2021, 24(12): 1091-1098.
[8] Kim, B.J. and Kim, J.S. (2014) Ischemic Stroke Subtype Classification: An Asian Viewpoint. Journal of Stroke, 16, 8-17. [Google Scholar] [CrossRef] [PubMed]
[9] Qureshi, A.I. and Caplan, L.R. (2014) Intracranial Atherosclerosis. Lancet, 383, 984-998. [Google Scholar] [CrossRef] 
[10] Kim, Y.W., Hong, J.M., Park, D.G., et al. (2016) Effect of Intracranial Atherosclerotic Disease on Endovascular Treatment for Patients with Acute Vertebrobasilar Occlusion. American Journal of Neuroradiology, 37, 2072-2078. [Google Scholar] [CrossRef] 
[11] Lee, J.S., Lee, S.J., Yoo, J.S., et al. (2018) Prognosis of Acute Intracranial Atherosclerosis-Related Occlusion after Endovascular Treatment. Journal of Stroke, 20, 394-403. [Google Scholar] [CrossRef] [PubMed]
[12] Lee, J.S., Hong, J.M., Lee, K.S., et al. (2015) Endovascular Therapy of Cerebral Arterial Occlusions: Intracranial Atherosclerosis versus Embolism. Journal of Stroke and Cerebrovascular Diseases, 24, 2074-2080. [Google Scholar] [CrossRef] [PubMed]
[13] Hwang, Y.H., Kim, Y.W., Kang, D.H., Kim, Y.S. and Liebeskind, D.S. (2016) Impact of Target Arterial Residual Stenosis on Outcome after Endovascular Revasculariza-tion. Stroke, 47, 1850-1857. [Google Scholar] [CrossRef] 
[14] Li, H., Ma, H.Y., Zhang, L., et al. (2022) Early Diagnosis of Intracranial Atherosclerotic Large Vascular Occlusion: A Prediction Model Based on DIRECT-MT Data. Frontiers in Neurology, 13, Article 1026815. [Google Scholar] [CrossRef] [PubMed]
[15] Lee, JS.., Hong, J.M. and Kim, J.S. (2017) Diagnostic and Ther-apeutic Strategies for Acute Intracranial Atherosclerosis-Related Occlusions. Journal of Stroke, 19, 143-151. [Google Scholar] [CrossRef] [PubMed]
[16] Horie, N., Tateishi, Y., Morikawa, M., et al. (2016) Acute Stroke with Major Intracranial Vessel Occlusion: Characteristics of Cardioembolism and Atherosclerosis-Related in Situ Steno-sis/Occlusion. Journal of Clinical Neuroscience, 32, 24-29. [Google Scholar] [CrossRef] [PubMed]
[17] Jia, B., Feng, L., Liebeskind, D.S., et al. (2018) Mechanical Thrombectomy and Rescue Therapy for Intracranial Large Artery Occlusion with Underlying Atherosclerosis. Journal of NeuroInterventional Surgery, 10, 746-750. [Google Scholar] [CrossRef] [PubMed]
[18] Ma, Y.H., Leng, X.Y., Dong, Y., et al. (2019) Risk Factors for Intracranial Atherosclerosis: A Systematic Review and Eta-Analysis. Atherosclerosis, 281, 71-77. [Google Scholar] [CrossRef] [PubMed]
[19] Koga, M., Kanaoka, Y., Okamoto, M., et al. (2020) Varenicline Aggravates Atherosclerotic Plaque Formation in Nicotine-Pretreated ApoE Knockout Mice Due to Enhanced OxLDL Uptake by Macrophages through Downregulation of ABCA1 and ABCG1 Expression. Journal of Pharmaco-logical Sciences, 142, 9-15. [Google Scholar] [CrossRef] [PubMed]
[20] Han, Y., Zhang, R., Yang, D., et al. (2022) Risk Factors for Asymptomatic and Symptomatic Intracranial Atherosclerosis Determined by Magnetic Resonance Vessel Wall Imaging in Chinese Population: A Case-Control Study. Therapeutics and Clinical Risk Management, 18, 61-70. [Google Scholar] [CrossRef] 
[21] Puetz, V., Dzialowski, I., Hill, M.D., et al. (2008) Intracranial Thrombus Extent Predicts Clinical Outcome, Final Infarct Size and Hemorrhagic Transformation in Ischemic Stroke: The Clot Burden Score. International Journal of Stroke, 3, 230-236. [Google Scholar] [CrossRef] [PubMed]
[22] Boodt, N., Compagne, K.C.J., Dutra, B.G., et al. (2020) Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients with Acute Ischemic Stroke: A MR CLEAN Registry Substudy. Stroke, 51, 1727-1735. [Google Scholar] [CrossRef] 
[23] Baek, J.H., Kim, B.M., Kim, J.W., et al. (2020) Utility of Leptomeningeal Collaterals in Predicting Intracranial Atherosclerosis-Related Large Vessel Occlusion in Endovascular Treatment. Journal of Clinical Medicine, 9, Article 2784. [Google Scholar] [CrossRef] [PubMed]
[24] Rebello, L.C., Bouslama, M., Haussen, D.C., et al. (2017) Stroke Etiolo-gy and Collaterals: Atheroembolic Strokes Have Greater Collateral Recruitment than Cardioembolic Strokes. European Journal of Neurology, 24, 762-767. [Google Scholar] [CrossRef] [PubMed]
[25] Guglielmi, V., LeCouffe, N.E., Zinkstok, S.M., et al. (2019) Collateral Cir-culation and Outcome in Atherosclerotic versus Cardioembolic Cerebral Large Vessel Occlusion. Stroke, 50, 3360-3368. [Google Scholar] [CrossRef] 
[26] 何亚玲, 沈雪阳, 胡志林, 等. 大动脉粥样硬化与心源性栓塞所致急性前循环颅内大血管闭塞患者侧支循环的差异及其影响因素[J]. 解放军医学杂志, 2022, 47(5): 479-485.
[27] Suh, H.I., Hong, J.M., Lee, K.S., et al. (2016) Imaging Predictors for Atherosclerosis-Related Intracranial Large Artery Occlusions in Acute Anterior Circulation Stroke. Journal of Stroke, 18, 352-354. [Google Scholar] [CrossRef] [PubMed]
[28] Berge, E., Nakstad, P.H., Sandset, P.M. and HAEST Study Group (2001) Large Middle Cerebral Artery Infarctions and the Hyperdense Middle Cerebral Artery Sign in Patients with Atrial Fibrillation. Acta Radiologica, 42, 261-268. [Google Scholar] [CrossRef] [PubMed]
[29] Kim, S.K., Baek, B.H., Lee, Y.Y. and Yoon, W. (2017) Clini-cal Implications of CT Hyperdense Artery Sign in Patients with Acute Middle Cerebral Artery Occlusion in the Era of Modern Mechanical Thrombectomy. Journal of Neurology, 264, 2450-2456. [Google Scholar] [CrossRef] [PubMed]
[30] Baek, J.H., Kim, B.M., Kim, D.J., et al. (2016) Importance of Truncal-Type Occlusion in Stentriever-Based Thrombectomy for Acute Stroke. Neurology, 87, 1542-1550. [Google Scholar] [CrossRef] 
[31] Yi, T.Y., Chen, W.H., Wu, Y.M., et al. (2019) Microcath-eter “First-Pass Effect” Predicts Acute Intracranial Artery Atherosclerotic Disease-Related Occlusion. Neurosurgery, 84, 1296-1305. [Google Scholar] [CrossRef] [PubMed]
[32] Garcia-Bermejo, P., Patro, S.N., Ahmed, A.Z., et al. (2019) Baseline Occlusion Angiographic Appearance on Mechanical Thrombectomy Suggests Underlying Etiology and Out-come. Frontiers in Neurology, 10, Article 499. [Google Scholar] [CrossRef] [PubMed]
[33] Jin, X., Shi, F., Chen, Y., Zheng, X. and Zhang, J. (2020) Jet-Like Appearance in Angiography as a Predictive Image Marker for the Occlusion of Intracranial Atherosclerotic Stenosis. Frontiers in Neurology, 11, Article 575567. [Google Scholar] [CrossRef] [PubMed]
[34] Wu, L., Rajah, G.B., Cosky, E.E., et al. (2021) Outcomes in Endovascular Therapy for Basilar Artery Occlusion: Intracranial Atherosclerotic Disease vs. Embolism. Aging and Dis-ease, 12, 404-414. [Google Scholar] [CrossRef] 
[35] 杨文进. 颅内动脉粥样硬化相关急性大血管闭塞血管内治疗疗效研究[D]: [博士学位论文]. 重庆: 中国人民解放军海军军医大学, 2020.[CrossRef] 
[36] Fitzgerald, S., Dai, D., Wang, S., et al. (2019) Plate-let-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated with a Large Artery Atherosclerosis Source. Stroke, 50, 1907-1910. [Google Scholar] [CrossRef] 
[37] Gong, L., Zheng, X., Feng, L., et al. (2019) Bridging Therapy versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke Due To Middle Cerebral Ar-tery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi. Cell Transplant, 28, 684-690. [Google Scholar] [CrossRef] [PubMed]
[38] Fitzgerald, S., Rossi, R., Mereuta, O.M., et al. (2021) Per-Pass Analysis of Acute Ischemic Stroke Clots: Impact of Stroke Etiology on Extracted Clot Area and Histological Composi-tion. Journal of NeuroInterventional Surgery, 13, 1111-1116. [Google Scholar] [CrossRef] [PubMed]
[39] Liebeskind, D.S., Sanossian, N., Yong, W.H., et al. (2011) CT and MRI Early Vessel Signs Reflect Clot Composition in Acute Stroke. Stroke, 42, 1237-1243. [Google Scholar] [CrossRef] 
[40] Duffy, S., McCarthy, R., Farrell, M., et al. (2019) Per-Pass Analysis of Thrombus Composition in Patients with Acute Ischemic Stroke Undergoing Mechanical Throm-bectomy. Stroke, 50, 1156-1163. [Google Scholar] [CrossRef] 

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