GSDMD在肿瘤中的研究进展
Research Progress of GSDMD in Tumors
DOI: 10.12677/ACM.2024.142408, PDF,   
作者: 白鹏伟, 白兆兆:宁夏医科大学临床医学院,宁夏 银川;张永斌:甘肃省人民医院肿瘤外科,甘肃 兰州;安心桥, 许 焱:甘肃中医药大学第一临床医学院,甘肃 兰州;达明绪*:宁夏医科大学临床医学院,宁夏 银川;甘肃省人民医院肿瘤外科,甘肃 兰州
关键词: GSDMD细胞焦亡肿瘤GSDMD Pyroptosis Tumor
摘要: GSDMD属于gasdermin家族,是细胞焦亡通路当中的关键因子,其与gasdermin家族其他的因子包括GSDMA、GSDMB、GSDMC、GSDME和DFNB59一样都具有相同的双域结构,这种结构诱导了细胞焦亡的发生。细胞焦亡与机体的防御、炎症、自身免疫性疾病和许多其他系统性疾病中均存在着千丝万缕的联系,而GSDMD又作为细胞焦亡的关键触发点与许多疾病的发生都存在联系。本文就GSDMD在肿瘤当中的研究进展作一综述。
Abstract: GSDMD is a member of the gasdermin family and plays a crucial role in the pyroptosis pathway. It has the same dual-domain structure as other members of the gasdermin family, such as GSDMA, GSDMB, GSDMC, GSDME, and DFNB59, which triggers pyroptosis. Pyroptosis is closely associated with the body’s defense, inflammation, autoimmune diseases, and many other systemic diseases. GSDMD, a critical trigger of pyroptosis, is associated with the development of numerous diseases. This article reviews the research progress on gasdermin D (GSDMD) in tumors.
文章引用:白鹏伟, 张永斌, 安心桥, 白兆兆, 许焱, 达明绪. GSDMD在肿瘤中的研究进展[J]. 临床医学进展, 2024, 14(2): 2885-2891. https://doi.org/10.12677/ACM.2024.142408

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