EB病毒相关嗜血细胞综合征1例报道并文献复习

EB Virus-Associated Hemophilic Syndrome: A Case Report and Literature Review

摘要: 目的：探讨成人EB病毒(EBV)相关嗜血细胞综合征(HPS)的临床症状体征和影像学表现，提高临床诊断准确率，减少漏诊和误诊。方法：回顾性分析2021年11月西安医学院第一附属医院呼吸与危重症医学科收治的1例成人EBV相关HPS患者的资料，分析诊疗过程。结果：患者主要临床表现为发热、血小板减少和脾肿大、胆汁淤积、脂肪肝，血NGS对EB病毒DNA检测阳性，结合病史查体及辅助检查结果明确诊断为EB病毒相关嗜血细胞综合征。结论：成人EBV相关HPS临床表现多变，缺乏特异性，血NGS检测和腹部CT可协助明确诊断，提高了临床医师对该病的诊出率，减少误诊漏诊的发生。

Abstract: Objective: To explore the clinical symptoms, signs and imaging findings of adult EB virus (EBV)- as-sociated hemophilic syndrome (HPS), so as to improve the accuracy of clinical diagnosis and reduce missed diagnosis and misdiagnosis. Method: The data of an adult patient with EBV-related HPS treated in the Department of Respiratory and Critical Care in The First Affiliated Hospital of Xi’an Medical College in November 2021 were analyzed retrospectively. Results: The main clinical mani-festations of the patients were fever, thrombocytopenia and splenomegaly, cholestasis and fatty liver. Blood NGS was positive for EB virus DNA. Combined with medical history and auxiliary exam-ination, the patient was diagnosed as EB virus-associated hemophilia syndrome. Conclusion: The clinical manifestations of adult EBV-related HPS are changeable and lack of specificity. The detec-tion of blood NGS and abdominal CT can help to make a clear diagnosis, improve the diagnosis rate of clinicians and reduce the occurrence of misdiagnosis and missed diagnosis.