甘油三酯葡萄糖指数与颈动脉粥样硬化的相关性研究进展
Research Progress on the Relationship between Triglyceride Glucose Index and Carotid Atherosclerosis
DOI: 10.12677/ACM.2024.142440, PDF,    科研立项经费支持
作者: 蒋 叶:新疆医科大学第四临床医学院,新疆 乌鲁木齐;温晓林:新疆医科大学研究生学院,新疆 乌鲁木齐;买买提·依斯热依力:新疆维吾尔自治区人民医院科教中心,新疆 乌鲁木齐;李 岚*:新疆医科大学第四临床医学院,新疆 乌鲁木齐;新疆医科大学第四附属医院,心血管内科,新疆 乌鲁木齐
关键词: 心血管疾病甘油三酯葡萄糖指数动脉粥样硬化颈动脉斑块Cardiovascular Diseases Triglyceride Glucose Index Therosclerosis Carotid Plaque
摘要: 近年来甘油三酯葡萄糖指数已被提议可作为胰岛素抵抗的简单可靠的替代指标,是心血管病结局的独立预测因子。研究表明甘油三酯葡萄糖指数与颈动脉粥样硬化的发生显著相关。颈动脉粥样硬化程度在一定水平上可以反应周身血管病变的严重程度,有心血管事件预测方面的优势。基于国内外文献,现主要就甘油三酯葡萄糖指数对颈动脉粥样硬化的临床应用价值及最新研究进展作以总结叙述。
Abstract: In recent years, triglyceride glucose index has been proposed as a simple and reliable alternative index of insulin resistance and an independent predictor of cardiovascular outcome. Studies have shown that triglyceride glucose index is significantly related to the occurrence of carotid athero-sclerosis. The degree of carotid atherosclerosis can reflect the severity of systemic vascular lesions to a certain extent, and has the advantage of predicting cardiovascular events. Based on domestic and foreign literature, this paper mainly summarizes the clinical application value and the latest research progress of triglyceride glucose index in carotid atherosclerosis.
文章引用:蒋叶, 温晓林, 买买提·依斯热依力, 李岚. 甘油三酯葡萄糖指数与颈动脉粥样硬化的相关性研究进展[J]. 临床医学进展, 2024, 14(2): 3106-3113. https://doi.org/10.12677/ACM.2024.142440

参考文献

[1] Song, P., Fang, Z., Wang, H., et al. (2020) Global and Regional Prevalence, Burden, and Risk Factors for Carotid Ath-erosclerosis: A Systematic Review, Meta-Analysis, and Modelling Study. The Lancet Global Health, 8, E721-E729. [Google Scholar] [CrossRef
[2] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2021概要[J]. 中国循环杂志, 2022, 37(6): 553-578.
[3] Zhu, G., Hom, J., Li, Y., et al. (2020) Carotid Plaque Imaging and the Risk of Atherosclerotic Cardiovascular Disease. Cardiovascular Diagnosis and Therapy, 10, 1048-1067. [Google Scholar] [CrossRef] [PubMed]
[4] Ye, Z., Xie, E., Gao, Y., et al. (2022) The Triglyceride Glucose Index Is Associated with Future Cardiovascular Disease Nonlinearly in Middle-Aged and Elderly Chinese Adults. BMC Endocrine Disorders, 22, Article No. 242. [Google Scholar] [CrossRef] [PubMed]
[5] Hoshino, T., Mizuno, T., Ishizuka, K., et al. (2022) Triglycer-ide-Glucose Index as a Prognostic Marker after Ischemic Stroke or Transient Ischemic Attack: A Prospective Observa-tional Study. Cardiovascular Diabetology, 21, Article No. 264. [Google Scholar] [CrossRef] [PubMed]
[6] Agacayak, K.S., Guler, R. and Sezgin Karatas, P. (2020) Rela-tion between the Incidence of Carotid Artery Calcification and Systemic Diseases. Clinical Interventions in Aging, 15, 821-826. [Google Scholar] [CrossRef
[7] Baba, M., Maris, M., Jianu, D., et al. (2023) The Impact of the Blood Lipids Levels on Arterial Stiffness. Journal of Cardiovascular Development and Disease, 10, Article 127. [Google Scholar] [CrossRef] [PubMed]
[8] Michaeli, D.T., Michaeli, J.C., Albers, S., et al. (2023) Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention. American Journal of Cardio-vascular Drugs, 23, 477-495. [Google Scholar] [CrossRef] [PubMed]
[9] Poznyak, A., Grechko, A.V., Poggio, P., et al. (2020) The Dia-betes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation. In-ternational Journal of Molecular Sciences, 21, Article 1835. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, X.F., Zhang, Y.X. and Ma, H.Y. (2020) Targeted Profiling of Amino Acid Metabolome in Serum by a Liquid Chroma-tography-Mass Spectrometry Method: Application to Identify Potential Markers for Diet-Induced Hyperlipidemia. Ana-lytical Methods, 12, 2355-2362. [Google Scholar] [CrossRef
[11] Li, Y., Kwong, D.L., Wu, V.W., et al. (2021) Computer-Assisted Ultrasound Assessment of Plaque Characteristics in Radiation-Induced and Non-Radiation-Induced Carotid Atherosclerosis. Quantitative Imaging in Medicine and Surgery, 11, 2292-2306. [Google Scholar] [CrossRef] [PubMed]
[12] Dharmakidari, S., Bhattacharya, P. and Chaturvedi, S. (2017) Carotid Artery Stenosis: Medical Therapy, Surgery, and Stenting. Current Neurology and Neuroscience Reports, 17, Article No. 77. [Google Scholar] [CrossRef] [PubMed]
[13] Gudmundsson, E.F., Björnsdottir, G., Sigurdsson, S., et al. (2022) Carotid Plaque Is Strongly Associated with Coronary Artery Calcium and Predicts Incident Coronary Heart Dis-ease in a Population-Based Cohort. Atherosclerosis, 346, 117-123. [Google Scholar] [CrossRef] [PubMed]
[14] Ihle-Hansen, H., Vigen, T., Berge, T., et al. (2023) Ca-rotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort from the General Population. Journal of the American Heart Association, 12, e30739. [Google Scholar] [CrossRef
[15] Shenouda, R., Vancheri, S., Maria, Bassi, E., et al. (2021) The Relationship between Carotid and Coronary Calcification in Patients with Coronary Artery Disease. Clinical Physiology and Functional Imaging, 41, 271-280. [Google Scholar] [CrossRef] [PubMed]
[16] Seo, J., Kim, G.S., Lee, H.Y., et al. (2019) Prevalence and Clinical Out-comes of Asymptomatic Carotid Artery Stenosis in Patients Undergoing Concurrent Coronary and Carotid Angiography. Yonsei Medical Journal, 60, 542-546. [Google Scholar] [CrossRef] [PubMed]
[17] Visseren, F., Mach, F., Smulders, Y, M., et al. (2021) 2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice. European Heart Journal, 42, 3227-3337. [Google Scholar] [CrossRef] [PubMed]
[18] Dinoto, E., Mirabella, D., Ferlito, F., et al. (2023) Carotid Artery Disease in the Era of Biomarkers: A Pilot Study. Diagnostics, 13, Article 644. [Google Scholar] [CrossRef] [PubMed]
[19] Li, X., Guo, D., Hu, Y., et al. (2023) Potential Biomarkers and Therapeutic Targets: Inflammation and Oxidative Stress in Left Carotid Artery Stenosis with Coronary Artery Disease. Current Pharmaceutical Design, 29, 966-979. [Google Scholar] [CrossRef] [PubMed]
[20] Shi, L., Liu, J., Zhu, X., et al. (2022) Triglyceride Glucose Index Was a Predictor of 6-Month Readmission Caused by Pulmonary Infection of Heart Failure Patients. In-ternational Journal of Endocrinology, 2022, Article ID: 1131696. [Google Scholar] [CrossRef] [PubMed]
[21] Miao, M., Zhou, G., Bao, A., et al. (2022) Triglyceride-Glucose Index and Common Carotid Artery Intima-Media Thickness in Patients with Ischemic Stroke. Cardiovascular Diabetology, 21, Article No. 43. [Google Scholar] [CrossRef] [PubMed]
[22] Wu, Z., Wang, J., Li, Z., et al. (2021) Triglyceride Glucose Index and Carotid Atherosclerosis Incidence in the Chinese Population: A Prospective Cohort Study. Nutrition, Metabolism and Cardiovascular Diseases, 31, 2042-2050. [Google Scholar] [CrossRef] [PubMed]
[23] Lu, Y.W., Chang, C.C., Chou, R.H., et al. (2021) Gender Dif-ference in the Association between TyG Index and Subclinical Atherosclerosis: Results from the I-Lan Longitudinal Ag-ing Study. Cardiovascular Diabetology, 20, Article No. 206. [Google Scholar] [CrossRef] [PubMed]
[24] Zhong, H., Shao, Y., Guo, G., et al. (2023) Association between the Triglyceride-Glucose Index and Arterial Stiffness: A Meta-Analysis. Medicine, 102, e33194. [Google Scholar] [CrossRef
[25] Zhang, Y., Wu, Z., Li, X., et al. (2022) Association between the Triglyceride-Glucose Index and Carotid Plaque Incidence: A Longitudinal Study. Cardiovascular Diabetology, 21, Article No. 244. [Google Scholar] [CrossRef] [PubMed]
[26] Li, W., Chen, D., Tao, Y., et al. (2022) Association between Tri-glyceride-Glucose Index and Carotid Atherosclerosis Detected by Ultrasonography. Cardiovascular Diabetology, 21, Article No. 137. [Google Scholar] [CrossRef] [PubMed]
[27] Li, Z., He, Y., Wang, S., et al. (2022) Association between Tri-glyceride Glucose Index and Carotid Artery Plaque in Different Glucose Metabolic States in Patients with Coronary Heart Disease: A RCSCD-TCM Study in China. Cardiovascular Diabetology, 21, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[28] Yang, X., Gao, Z., Huang, X., et al. (2022) The Correlation of Atherosclerosis and Triglyceride Glucose Index: A Secondary Analysis of A National Cross-Sectional Study of Japanese. BMC Cardiovascular Disorders, 22, Article No. 250. [Google Scholar] [CrossRef] [PubMed]
[29] Tang, X., Zhang, L., Li, Y., et al. (2022) Relationship between Triglyceride-Glucose Index and Carotid Plaques in a High-Stroke-Risk Population in Southeast China: A Population-Based Cross-Sectional Survey. Frontiers in Endocri-nology, 13, Article 1023867. [Google Scholar] [CrossRef] [PubMed]
[30] Yu, H., Tao, L., Li, Y.G., et al. (2023) Association between Triglyceride-Glucose Index Trajectories and Carotid Atherosclerosis Progression. Cardio-vascular Diabetology, 22, Article No. 130. [Google Scholar] [CrossRef] [PubMed]
[31] Jiang, Z.Z., Zhu, J.B., Shen, H.L., et al. (2022) A High Triglyc-eride-Glucose Index Value Is Associated with an Increased Risk of Carotid Plaque Burden in Subjects with Prediabetes and New-Onset Type 2 Diabetes: A Real-World Study. Frontiers in Cardiovascular Medicine, 9, Article 832491. [Google Scholar] [CrossRef] [PubMed]
[32] Sajdeya, O., Beran, A., Mhanna, M., et al. (2022) Triglyceride Glucose Index for the Prediction of Subclinical Atherosclerosis and Arterial Stiffness: A Meta-Analysis of 37,780 Indi-viduals. Current Problems in Cardiology, 47, Article ID: 101390. [Google Scholar] [CrossRef] [PubMed]
[33] Özbiçer, S., Yüksel, G. and Deniz Urgun, Ö. (2022) Triglyc-eride Glucose Index Is Independently Associated with Aortic Intima-Media Thickness in Patients without Known Ather-osclerotic Cardiovascular Disease or Diabetes. Diabetes & Vascular Disease Research, 19, No. 5. [Google Scholar] [CrossRef] [PubMed]
[34] Hong, S., Han, K. and Park, C.Y. (2020) The Triglyceride Glu-cose Index Is a Simple and Low-Cost Marker Associated with Atherosclerotic Cardiovascular Disease: A Popula-tion-Based Study. BMC Medicine, 18, Article No. 361. [Google Scholar] [CrossRef] [PubMed]
[35] Morales-Gurrola, G., Simental-Mendía, L.E., Castellanos-Juárez, F.X., et al. (2020) The Triglycerides and Glucose Index Is Associated with Cardiovascular Risk Factors in Metabolically Obese Normal-Weight Subjects. Journal of Endocrinological Investigation, 43, 995-1000. [Google Scholar] [CrossRef] [PubMed]
[36] Gao, J.W., Hao, Q.Y., Gao, M., et al. (2021) Triglycer-ide-Glucose Index in the Development of Peripheral Artery Disease: Findings from the Atherosclerosis Risk in Commu-nities (ARIC) Study. Cardiovascular Diabetology, 20, Article No. 126. [Google Scholar] [CrossRef] [PubMed]
[37] Jung, M.H., Yi, S.W., An, S.J., et al. (2022) Associations be-tween the Triglyceride-Glucose Index and Cardiovascular Disease in Over 150,000 Cancer Survivors: A Popula-tion-Based Cohort Study. Cardiovascular Diabetology, 21, Article No. 52. [Google Scholar] [CrossRef] [PubMed]
[38] Karadeniz, F.Ö., Sancaktepe, E.A. and Karadeniz, Y. (2022) High Triglyceride-Glucose Index Is Associated with Poor Prognosis in Patients with Acute Coronary Syndrome in Long-Term Follow-Up. Angiology, 74, 139-148. [Google Scholar] [CrossRef] [PubMed]
[39] Thai, P.V., Tien, H.A., Van Minh, H., et al. (2020) Triglyceride Glucose Index for the Detection of Asymptomatic Coronary Artery Stenosis in Patients with Type 2 Diabetes. Cardio-vascular Diabetology, 19, Article No. 137. [Google Scholar] [CrossRef] [PubMed]
[40] Wu, Z., Zhou, D., Liu, Y., et al. (2021) Association of TyG In-dex and TG/HDL-C Ratio with Arterial Stiffness Progression in a Non-Normotensive Population. Cardiovascular Dia-betology, 20, Article No. 134. [Google Scholar] [CrossRef] [PubMed]
[41] Ding, X., Wang, X., Wu, J., et al. (2021) Triglyceride-Glucose Index and the Incidence of Atherosclerotic Cardiovascular Diseases: A Meta-Analysis of Cohort Studies. Cardiovascular Diabetology, 20, Article No. 76. [Google Scholar] [CrossRef] [PubMed]
[42] Wang, X., Feng, B., Huang, Z., et al. (2022) Relationship of Cumulative Exposure to the Triglyceride-Glucose Index with Ischemic Stroke: A 9-Year Prospective Study in the Kailuan Cohort. Cardiovascular Diabetology, 21, Article No. 66. [Google Scholar] [CrossRef] [PubMed]
[43] Zhou, Y., Pan, Y., Yan, H., et al. (2020) Triglyceride Glucose Index and Prognosis of Patients with Ischemic Stroke. Frontiers in Neurology, 11, Article 456. [Google Scholar] [CrossRef] [PubMed]