高血压合并睡眠呼吸暂停低通气综合征与动脉硬化的研究进展

Research Progress of Hypertension Combined with Obstructive Sleep Apnea-Hypopnea Syndrome and Arteriosclerosis

摘要: 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)为一种常见的睡眠呼吸障碍性疾病，与高血压、心血管疾病等密切相关。高血压合并OSAHS患者表现出特异的血压特点，二者合并会加剧心血管动脉硬化不良事件的发生和死亡风险。动脉硬化是心血管疾病的重要病理基础，动态动脉硬化指数(AASl)及血浆致动脉硬化指数(AIP)是近年提出的评价动脉硬化度的新型敏感指标，对于早期识别高血压合并OSAHS发生动脉硬化的高危人群，行危险分层和及时防治具有显著的临床意义。本文就高血压合并OSAHS与动脉硬化的研究进展予以综述。

Abstract: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep breathing disorder, which is closely related to hypertension and cardiovascular diseases. Patients with hypertension com-bined with OSAHS show specific blood pressure characteristics, and the combination of the two will increase the occurrence of adverse events and death risk of cardiovascular arteriosclerosis. Arteri-osclerosis is an important pathological basis of cardiovascular diseases. Ambulatory arterial stiff-ness index (AASl) and Atherogenic index of plasma (AIP) are new sensitive indexes proposed in re-cent years to evaluate the degree of arteriosclerosis, which have significant clinical significance for early identification of high-risk groups of arteriosclerosis caused by hypertension combined with OSAHS, risk stratification and timely prevention and treatment. This article reviews the research progress of hypertension complicated with OSAHS and arteriosclerosis.