伴有快感缺乏的抑郁障碍患者奖赏网络功能变化研究进展
Research Progress on the Functional Changes of Reward Network in Patients with Depressive Disorder Accompanied by Anhedonia
DOI: 10.12677/ACM.2024.142463, PDF,   
作者: 于雅琼, 程五一凡：内蒙古医科大学精神卫生学院，内蒙古 呼和浩特；于东升*, 吕东升：内蒙古自治区精神卫生中心，内蒙古 呼和浩特
关键词: 抑郁障碍；快感缺乏；奖赏网络；Depressive Disorder； Anhedonia； Rewards Network
摘要: 抑郁障碍是最常见的精神疾病之一，快感缺乏是其核心症状，是指愉快体验能力的降低，在抑郁障碍患者中普遍存在，被证实是抗抑郁治疗预后差的预测因子，随着功能磁共振技术的发展，越来越多通过该方法的研究发现，具有快感缺乏的抑郁障碍患者与正常人相比，大脑奖赏网络各个脑区的功能变化存在差异，本文对具有快感缺乏的抑郁患者的奖赏网络内不同脑区功能变化的研究开展叙述。
Abstract: Depressive disorder is one of the most common mental disorders, and anhedonia is its core symp-tom, which refers to the decrease of the ability to experience pleasure. It is common in depressive patients and has been confirmed as a predictor of poor prognosis in antidepressant treatment. With the development of functional magnetic resonance imaging technology, more and more studies us-ing this method have found that there are differences in the functional changes of various brain re-gions in the brain reward network between depressive patients with anhedonia and normal people. This paper describes the research on the functional changes of different brain regions in the reward network of depressive patients with anhedonia.
文章引用：于雅琼, 于东升, 吕东升, 程五一凡. 伴有快感缺乏的抑郁障碍患者奖赏网络功能变化研究进展[J]. 临床医学进展, 2024, 14(2): 3278-3284. https://doi.org/10.12677/ACM.2024.142463

参考文献

[1] 陆林. 精神病学[M]. 第6版. 北京: 人民卫生出版社, 2018: 413.
[2] Frankish, H., Boyce, N. and Horton, R. (2018) Mental Health for All: A Global Goal. The Lancet, 392, 1493-1494. [Google Scholar] [CrossRef] 
[3] Goodyer, I.M., Reynolds, S., Barrett, B., et al. (2017) Cog-nitive Behavioural Therapy and Short-Term Psychoanalytical Psychotherapy versus a Brief Psychosocial Intervention in Adolescents with Unipolar Major Depressive Disorder (IMPACT): A Multicentre, Pragmatic, Observer-Blind, Random-ised Controlled Superiority Trial. The Lancet Psychiatry, 4, 109-119. [Google Scholar] [CrossRef] 
[4] Ducasse, D., Loas, G., Dassa, D., et al. (2018) Anhedonia Is Associated with Suicidal Ideation Independently of Depression: A Meta-Analysis. Depress Anxiety, 35, 382-392. [Google Scholar] [CrossRef] [PubMed]
[5] 梁健宁, 顾雨婷, 周晨, 王丽君, 杨娟, 朱国辉, 黄光影, 王毅, 王艳郁. 抑郁症患者外显及内隐情绪面孔的反应抑制特点[J]. 中国心理卫生杂志, 2022, 36(10): 817-823.
[6] 王东方, 田凯, 谢光荣, 等. 快感缺失、压力和神经质人格对抑郁症发病的影响[J]. 中国临床心理学杂志, 2017, 25(4): 754-757.
[7] Treadway, M.T. and Zald, D.H. (2011) Reconsidering Anhedonia in Depression: Lessons from Transla-tional Neuroscience. Neuroscience & Biobehavioral Reviews, 35, 537-555. [Google Scholar] [CrossRef] [PubMed]
[8] Wu, H., Mata, J., Furman, D.J., et al. (2017) Anticipatory and Consummatory Pleasure and Displeasure in Major Depressive Disorder: An Experience Sampling Study. Journal of Ab-normal Psychology, 126, 149-159. [Google Scholar] [CrossRef] [PubMed]
[9] Hallford, D.J., Barry, T.J., Austin, D.W., et al. (2020) Impairments in Episodic Future Thinking for Positive Events and Anticipatory Pleasure in Major Depression. Journal of Affective Dis-orders, 260, 536-543. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, X., He, K., Chen, T., et al. (2021) Therapeutic Efficacy of Connectivity-Directed Transcranial Magnetic Stimulation on Anticipatory Anhedonia. Depress Anxiety, 38, 972-984. [Google Scholar] [CrossRef] [PubMed]
[11] Hu, Y., Zhao, C., Zhao, H., et al. (2023) Abnormal Functional Connectivity of the Nucleus Accumbens Subregions Mediates the Association between Anhedonia and Major Depressive Disorder. BMC Psychiatry, 23, Article No. 282. [Google Scholar] [CrossRef] [PubMed]
[12] Zhang, T., He, K., Bai, T., et al. (2021) Altered Neural Activity in the Reward-Related Circuit and Executive Control Network Associated with Amelioration of Anhedonia in Major De-pressive Disorder by Electroconvulsive Therapy. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 109, Article ID: 110193. [Google Scholar] [CrossRef] [PubMed]
[13] Cao, B., Park, C., Subramaniapillai, M., et al. (2019) The Effi-cacy of Vortioxetine on Anhedonia in Patients with Major Depressive Disorder. Frontiers in Psychiatry, 10, Article No. 17. [Google Scholar] [CrossRef] [PubMed]
[14] Fryer, S.L., Roach, B.J., Ford, J.M., et al. (2015) Relating In-trinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia. Neuropsychopharmacology, 40, 2705-2714. [Google Scholar] [CrossRef] [PubMed]
[15] Enneking, V., Krüssel, P., Zaremba, D., et al. (2019) Social Anhedonia in Major Depressive Disorder: A Symptom-Specific Neuroimaging Approach. Neuropsychopharmacology, 44, 883-889.
[16] Kumar, P., Goer, F., Murray, L., et al. (2018) Impaired Reward Prediction Error Encoding and Stria-tal-Midbrain Connectivity in Depression. Neuropsychopharmacology, 43, 1581-1588. [Google Scholar] [CrossRef] [PubMed]
[17] Green, I.W., Pizzagalli, D.A., Admon, R. and Kumar, P. (2019) Anhedonia Modulates the Effects of Positive Mood Induction on Reward-Related Brain Activation. Neuroimage, 193, 115-125. [Google Scholar] [CrossRef] [PubMed]
[18] Bartra, O., McGuire, J.T. and Kable, J.W. (2013) The Valu-ation System: A Coordinate-Based Meta-Analysis of BOLD FMRI Experiments Examining Neural Correlates of Subjec-tive Value. Neuroimage, 76, 412-427. [Google Scholar] [CrossRef] [PubMed]
[19] Grimm, C., Balsters, J.H. and Zerbi, V. (2021) Shedding Light on Social Reward Circuitry: (Un)Common Blueprints in Humans and Rodents. Neuroscientist, 27, 159-183. [Google Scholar] [CrossRef] [PubMed]
[20] Pizzagalli, D.A. (2014) Depression, Stress, and Anhedonia: To-ward a Synthesis and Integrated Model. Annual Review of Clinical Psychology, 10, 393-423. [Google Scholar] [CrossRef] [PubMed]
[21] Greenberg, T., Chase, H.W., Almeida, J.R., et al. (2015) Moderation of the Relationship between Reward Expectancy and Prediction Error-Related Ventral Striatal Reac-tivity by Anhedonia in Unmedicated Major Depressive Disorder: Findings from the EMBARC Study. American Journal of Psychiatry, 172, 881-891. [Google Scholar] [CrossRef] [PubMed]
[22] Yang, X.H., Tian, K., Wang, D.F., et al. (2017) Anhedonia Correlates with Abnormal Functional Connectivity of the Superior Temporal Gyrus and the Caudate Nucleus in Patients with First-Episode Drug-Naive Major Depressive Disorder. Journal of Affective Disorders, 218, 284-290. [Google Scholar] [CrossRef] [PubMed]
[23] Ely, B.A., Nguyen, T.N.B., Tobe, R.H., et al. (2021) Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression. Frontiers in Psychiatry, 12, Article ID: 678709. [Google Scholar] [CrossRef] [PubMed]
[24] Gabbay, V., Ely, B.A., Li, Q., et al. (2013) Stria-tum-Based Circuitry of Adolescent Depression and Anhedonia. Journal of the American Academy of Child & Adolescent Psychiatry, 52, 628-641.e13. [Google Scholar] [CrossRef] [PubMed]
[25] Dombrovski, A.Y., Szanto, K., Clark, L., et al. (2015) Corticostria-tothalamic Reward Prediction Error Signals and Executive Control in Late-Life Depression. Psychological Medicine, 45, 1413-1424. [Google Scholar] [CrossRef] 
[26] Zhang, B., Lin, P., Shi, H., et al. (2016) Mapping Anhe-donia-Specific Dysfunction in a Transdiagnostic Approach: An ALE Meta-Analysis. Brain Imaging and Behavior, 10, 920-939. [Google Scholar] [CrossRef] [PubMed]
[27] Russo, S.J. and Nestler, E.J. (2013) The Brain Reward Circuitry in Mood Disorders. Nature Reviews Neuroscience, 14, 609-625. [Google Scholar] [CrossRef] [PubMed]
[28] Fan, J., Liu, W., Xia, J., et al. (2021) Childhood Trauma Is Associated with Elevated Anhedonia and Altered Core Reward Circuitry in Major Depression Patients and Controls. Human Brain Map-ping, 42, 286-297. [Google Scholar] [CrossRef] [PubMed]
[29] Liu, R., Wang, Y., Chen, X., et al. (2021) Anhedonia Correlates with Functional Connectivity of the Nucleus Accumbens Subregions in Patients with Major Depressive Disorder. Neu-roImage: Clinical, 30, Article ID: 102599. [Google Scholar] [CrossRef] [PubMed]
[30] Zhang, B., Li, S., Zhuo, C., et al. (2017) Altered Task-Specific Deactivation in the Default Mode Network Depends on Valence in Patients with Major Depressive Disorder. Journal of Affective Disorders, 207, 377-383. [Google Scholar] [CrossRef] [PubMed]
[31] Hwang, J.W., Xin, S.C., Ou, Y.M., et al. (2016) Enhanced Default Mode Network Connectivity with Ventral Striatum in Subthreshold Depression Individuals. Journal of Psychiatric Re-search, 76, 111-120. [Google Scholar] [CrossRef] [PubMed]
[32] Zhang, A., Yang, C., Li, G., et al. (2020) Functional Connec-tivity of the Prefrontal Cortex and Amygdala Is Related to Depression Status in Major Depressive Disorder. Journal of Affective Disorders, 274, 897-902. [Google Scholar] [CrossRef] [PubMed]
[33] Forbes, E.E., Hariri, A.R., Martin, S.L., et al. (2009) Altered Striatal Activation Predicting Real-World Positive Affect in Adolescent Major Depressive Disorder. American Journal of Psy-chiatry, 166, 64-73. [Google Scholar] [CrossRef] [PubMed]
[34] Light, S.N., Heller, A.S., Johnstone, T., et al. (2011) Reduced Right Ventrolateral Prefrontal Cortex Activity While Inhibiting Positive Affect Is Associated with Improvement in He-donic Capacity after 8 Weeks of Antidepressant Treatment in Major Depressive Disorder. Biological Psychiatry, 70, 962-968. [Google Scholar] [CrossRef] [PubMed]
[35] Rzepa, E. and Mccabe, C. (2018) Anhedonia and Depression Severity Dissociated by DmPFC Resting-State Functional Connectivity in Adolescents. Journal of Psychopharmacology, 32, 1067-1074. [Google Scholar] [CrossRef] [PubMed]
[36] Borsini, A., Wallis, A.S.J., Zunszain, P., et al. (2020) Character-izing Anhedonia: A Systematic Review of Neuroimaging across the Subtypes of Reward Processing Deficits in Depres-sion. Cognitive, Affective, & Behavioral Neuroscience, 20, 816-841. [Google Scholar] [CrossRef] [PubMed]
[37] Loureiro, J.R.A., Leaver, A., Vasavada, M., et al. (2020) Modu-lation of Amygdala Reactivity Following Rapidly Acting Interventions for Major Depression. Human Brain Mapping, 41, 1699-1710. [Google Scholar] [CrossRef] [PubMed]
[38] Stuhrmann, A., Dohm, K., Kugel, H., et al. (2013) Mood-Congruent Amygdala Responses to Subliminally Presented Facial Expressions in Major Depression: Associations with Anhedonia. Journal of Psychiatry & Neuroscience, 38, 249-258. [Google Scholar] [CrossRef] [PubMed]

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