ELK1在恶性肿瘤中的作用及调控机制的研究进展
Advances in the Role and Regulatory Mechanisms of ELK1 in Malignant Tumors
DOI: 10.12677/ACM.2024.142477, PDF,   
作者: 何 姣*, 韩志刚#, 俞婷婷:新疆医科大学第三临床医学院(附属肿瘤医院),新疆 乌鲁木齐
关键词: ELK1肿瘤分子机制文献综述ELK1 Tumor Molecular Mechanism Literature Review
摘要: ETS蛋白质家族由28个转录因子组成,ELK1是ETS转录因子家族和三元复合因子(ternary complex factor, TCF)亚家族成员。越来越多的研究显示,ELK1参与多种分子生物学进程,并且与人类恶性肿瘤的发生、发展、侵袭、转移等密切相关。本文通过总结ELK1在多种恶性肿瘤中的生物学过程,重点探讨其在人类恶性肿瘤中的主要功能和牵涉到的相关信号通路,探讨其潜在的临床意义及应用前景,为癌症的诊断、治疗及筛选预后生物标志物提供理论基础及参考依据。
Abstract: The ETS protein family consists of 28 transcription factors, and ELK1 is a member of the ETS tran-scription factor family and ternary complex factor (TCF) subfamily. More and more studies have shown that ELK1 is involved in a variety of molecular biological processes and is closely related to the occurrence, development, invasion and metastasis of human malignant tumors. In this paper, we summarize the biological processes of ELK1 in various malignant tumors, focus on its main func-tions and related signaling pathways in human malignant tumors, and explore its potential clinical significance and application prospects, so as to provide a theoretical basis for cancer diagnosis, treatment and screening of prognostic biomarkers.
文章引用:何姣, 韩志刚, 俞婷婷. ELK1在恶性肿瘤中的作用及调控机制的研究进展[J]. 临床医学进展, 2024, 14(2): 3391-3397. https://doi.org/10.12677/ACM.2024.142477

参考文献

[1] Babal, Y.K., Sonmez, E. and Aksan Kurnaz, I. (2023) Nervous System-Related Gene Regulatory Networks and Func-tional Evolution of ETS Proteins across Species. Bio Systems, 227-228, Article ID: 104891. [Google Scholar] [CrossRef] [PubMed]
[2] Du, L., Liu, Y., Li, C., et al. (2022) The Interaction between ETS Transcription Factor Family Members and MicroRNAs: A Novel Approach to Cancer Therapy. Biomedicine & Pharmacotherapy, 150, Article ID: 113069. [Google Scholar] [CrossRef] [PubMed]
[3] Kelle, D., Kırımtay, K., Selçuk, E., et al. (2019) Elk1 Affects Katanin and Spastin Proteins via Differential Transcriptional and Post-Transcriptional Regulations. PLOS ONE, 14, e0212518. [Google Scholar] [CrossRef] [PubMed]
[4] Prise, I. and Sharrocks, A.D. (2019) ELK1 Has a Dual Activating and Repressive Role in Human Embryonic Stem Cells. Wellcome Open Research, 4, Article No. 41. [Google Scholar] [CrossRef
[5] Harel, S., Sanchez, V., Moamer, A., et al. (2021) ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in Endothelial Cells. Frontiers in Physiology, 12, Article ID: 683651. [Google Scholar] [CrossRef] [PubMed]
[6] Zhao, H., Chen, M., Wang, J., et al. (2020) PCNA-Associated Factor KIAA0101 Transcriptionally Induced by ELK1 Controls Cell Proliferation and Apoptosis in Nasopharyngeal Car-cinoma: An Integrated Bioinformatics and Experimental Study. Aging, 12, 5992-6017. [Google Scholar] [CrossRef] [PubMed]
[7] Liu, J., Sun, Q., Zhao, J., et al. (2022) Early Death in Supraglottic Laryngeal Squamous Cell Carcinoma: A Population-Based Study. Ear, Nose & Throat Journal. [Google Scholar] [CrossRef] [PubMed]
[8] Shuang, Y., Liu, J., Niu, J., et al. (2021) A Novel Circular RNA CircPPFIA1 Promotes Laryngeal Squamous Cell Carcinoma Progression through Sponging MiR-340-3p and Regulating ELK1 Expression. Bioengineered, 12, 5220-5230. [Google Scholar] [CrossRef] [PubMed]
[9] Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[10] Li, K., Liu, Y., Ding, Y., et al. (2022) BCL6 Is Regulated by the MAPK/ELK1 Axis and Promotes KRAS-Driven Lung Cancer. The Journal of Clinical Investigation, 132, e161308. [Google Scholar] [CrossRef
[11] Yu, T.-T., Zhang, T., Su, F., et al. (2021) ELK1 Promotes Epitheli-al-Mesenchymal Transition and the Progression of Lung Adenocarcinoma by Upregulating B7-H3. Oxidative Medicine and Cellular Longevity, 2021, Article ID: 2805576. [Google Scholar] [CrossRef] [PubMed]
[12] Xia, C., Dong, X., Li, H., et al. (2022) Cancer Statistics in China and United States, 2022: Profiles, Trends, and Determinants. Chinese Medical Journal, 135, 584-590. [Google Scholar] [CrossRef
[13] Morgan, E., Soerjomataram, I., Rumgay, H., et al. (2022) The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortal-ity in 2020 and Projections to 2040: New Estimates from GLOBOCAN 2020. Gastroenterology, 163, 649-658.E2. [Google Scholar] [CrossRef] [PubMed]
[14] Zheng, Z.-Y., Chu, M.-Y., Lin, W., et al. (2022) Blocking STAT3 Signaling Augments MEK/ERK Inhibitor Efficacy in Esophageal Squamous Cell Carcinoma. Cell Death & Dis-ease, 13, Article No. 496. [Google Scholar] [CrossRef] [PubMed]
[15] López, M.J., Carbajal, J., Alfaro, A.L., et al. (2023) Characteris-tics of Gastric Cancer around the World. Critical Reviews in Oncology/Hematology, 181, Article ID: 103841. [Google Scholar] [CrossRef] [PubMed]
[16] Li, Z., Cheng, Y., Fu, K., et al. (2021) Circ-PTPDC1 Pro-motes the Progression of Gastric Cancer through Sponging Mir-139-3p by Regulating ELK1 and Functions as a Prog-nostic Biomarker. International Journal of Biological Sciences, 17, 4285-4304. [Google Scholar] [CrossRef] [PubMed]
[17] Li, P., Ge, D., Li, P., et al. (2020) CXXC Finger Protein 4 Inhibits the CDK18‐ERK1/2 Axis to Suppress the Immune Escape of Gastric Cancer Cells with Involvement of ELK1/MIR100HG Pathway. Journal of Cellular and Molecular Medicine, 24, 10151-10165. [Google Scholar] [CrossRef] [PubMed]
[18] Shinji, S., Yamada, T., Matsuda, A., et al. (2022) Recent Advances in the Treatment of Colorectal Cancer: A Review. Journal of Nippon Medical School, 89, 246-254. [Google Scholar] [CrossRef
[19] Zhao, S., Mi, Y., Zheng, B., et al. (2022) Highly‐Metastatic Colorectal Cancer Cell Released MiR‐181a‐5p‐Rich Extracellular Vesicles Promote Liver Metastasis by Activating He-patic Stellate Cells and Remodelling the Tumour Microenvironment. Journal of Extracellular Vesicles, 11, e12186. [Google Scholar] [CrossRef] [PubMed]
[20] Yan, G. and Lei, W. (2023) Role of ELK1 in Regulating Colorectal Cancer Progression: MiR-31-5p/CDIP1 Axis in CRC Pathogenesis. PeerJ, 11, e15602. [Google Scholar] [CrossRef] [PubMed]
[21] Ma, J., Liu, X., Chen, H., et al. (2021) C-KIT-ERK1/2 Signaling Activat-ed ELK1 and Upregulated Carcinoembryonic Antigen Expression to Promote Colorectal Cancer Progression. Cancer Science, 112, 655-667. [Google Scholar] [CrossRef] [PubMed]
[22] Klein, A.P. (2021) Pancreatic Cancer Epidemiology: Understanding the Role of Lifestyle and Inherited Risk Factors. Nature Reviews. Gastroenterology & Hepatology, 18, 493-502. [Google Scholar] [CrossRef] [PubMed]
[23] Yan, Q., Ni, C., Lin, Y., et al. (2021) ELK1 Enhances Pancreatic Cancer Progression via LGMN and Correlates with Poor Prognosis. Frontiers in Molecular Biosciences, 8, Article ID: 764900. [Google Scholar] [CrossRef] [PubMed]
[24] Chen, Q., Fu, Y., Liu, X., et al. (2023) Aberrant Expres-sion of CKS2 Induced by ELK1 Contributes to Malignant Progression of Pancreatic Cancer. Molecular Carcinogenesis. [Google Scholar] [CrossRef] [PubMed]
[25] Madani, S.P., Mirza‐Aghazadeh‐Attari, M., Mohseni, A., et al. (2023) Dif-fuse Infiltrative Hepatocellular Carcinoma: Multimodality Imaging Manifestations. Journal of Surgical Oncology, 127, 385-393. [Google Scholar] [CrossRef] [PubMed]
[26] Yan, Q., Lou, G., Qian, Y., et al. (2016) SPAG9 Is Involved in Hepatocarcinoma Cell Migration and Invasion via Modulation of ELK1 Expression. OncoTargets and Therapy, 9, 1067-1075. [Google Scholar] [CrossRef
[27] Gilyazova, I., Enikeeva, K., Rafikova, G., et al. (2023) Epi-genetic and Immunological Features of Bladder Cancer. International Journal of Molecular Sciences, 24, Article No. 9854. [Google Scholar] [CrossRef] [PubMed]
[28] Wang, J., Luo, J., Wu, X., et al. (2022) ELK1 Suppresses SYTL1 Expression by Recruiting HDAC2 in Bladder Cancer Progression. Human Cell, 35, 1961-1975. [Google Scholar] [CrossRef] [PubMed]
[29] Wang, W., Chen, S., Song, X., et al. (2020) ELK1/LncRNA-SNHG7/MiR-2682-5p Feedback Loop Enhances Bladder Cancer Cell Growth. Life Sciences, 262, Arti-cle ID: 118386. [Google Scholar] [CrossRef] [PubMed]
[30] Li, P., Shi, Y., Gao, D., et al. (2022) ELK1-Mediated YTHDF1 Drives Prostate Cancer Progression by Facilitating the Translation of Polo-Like Kinase 1 in an M6A Dependent Manner. International Journal of Biological Sciences, 18, 6145-6162. [Google Scholar] [CrossRef] [PubMed]
[31] Xie, W., Li, S., Guo, H., et al. (2023) Androgen Receptor Knockdown En-hances Prostate Cancer Chemosensitivity by Down‐Regulating FEN1 through the ERK/ELK1 Signalling Pathway. Can-cer Medicine, 12, 15317-15336. [Google Scholar] [CrossRef] [PubMed]
[32] Wei, S., Yu, Z., Shi, R., et al. (2022) GPX4 Suppresses Ferroptosis to Promote Malignant Progression of Endometrial Carcinoma via Transcriptional Activation by ELK1. BMC Cancer, 22, Article No. 881. [Google Scholar] [CrossRef] [PubMed]
[33] Huang, Y. and Luo, F. (2021) Elevated MicroRNA-130b-5p or Silenced ELK1 Inhibits Self-Renewal Ability, Proliferation, Migration, and Invasion Abilities, and Promotes Apoptosis of Cervical Cancer Stem Cells. IUBMB Life, 73, 118-129. [Google Scholar] [CrossRef] [PubMed]
[34] Hu, R. and Zhu, Z. (2019) ELK1‐Activated GPC3‐AS1/GPC3 Axis Promotes the Proliferation and Migration of Cervical Cancer Cells. The Journal of Gene Medicine, 21, e3099. [Google Scholar] [CrossRef] [PubMed]
[35] Trapani, D., Ginsburg, O., Fadelu, T., et al. (2022) Global Challenges and Policy Solutions in Breast Cancer Control. Cancer Treatment Reviews, 104, Article ID: 102339. [Google Scholar] [CrossRef] [PubMed]
[36] Yang, B., Wang, H., Xiao, J., et al. (2023) ELK1 / KIFC1 Axis Promotes Breast Cancer Cell Proliferation by Regulating Glutathione Metabolism. Journal of Obstetrics and Gynaecology Research, 49, 2175-2184. [Google Scholar] [CrossRef] [PubMed]
[37] Wang, S., Zhang, H., Liu, H., et al. (2021) ELK1-Induced Up-Regulation of KIF26B Promotes Cell Cycle Progression in Breast Cancer. Medical Oncology (Northwood, London, England), 39, Ar-ticle No. 15. [Google Scholar] [CrossRef] [PubMed]
[38] Zhang, Q., Wu, J., Zhang, X., et al. (2021) Transcription Factor ELK1 Accelerates Aerobic Glycolysis to Enhance Osteosarcoma Chemoresistance through MiR-134/PTBP1 Signaling Cascade. Aging, 13, 6804-6819. [Google Scholar] [CrossRef] [PubMed]
[39] Guo, D., Zhang, A., Suo, M., et al. (2023) ELK1-Induced Upregula-tion of Long Non-Coding TNK2-AS1 Promotes the Progression of Acute Myeloid Leukemia by EZH2-Mediated Epige-netic Silencing of CELF2. Cell Cycle (Georgetown, Tex.), 22, 117-130. [Google Scholar] [CrossRef] [PubMed]
[40] Chava, S., Bugide, S., Malvi, P., et al. (2022) Co-Targeting of Specific Epigenetic Regulators in Combination with CDC7 Potently Inhibit Melanoma Growth. IScience, 25, Article ID: 104752. [Google Scholar] [CrossRef] [PubMed]
[41] Sogut, M.S., Venugopal, C., Kandemir, B., et al. (2021) ETS-Domain Transcription Factor Elk-1 Regulates Stemness Genes in Brain Tumors and CD133+ Brain Tu-mor-Initiating Cells. Journal of Personalized Medicine, 11, Article No. 125. [Google Scholar] [CrossRef] [PubMed]
[42] Lv, P. and Xue, Y. (2021) ETS Like-1 Protein ELK1-Induced LncRNA LINC01638 Accelerates the Progression of Papillary Thyroid Cancer by Regulating Axin2 through Wnt/β-Catenin Sig-naling Pathway. Bioengineered, 12, 3873- 3885. [Google Scholar] [CrossRef] [PubMed]