1例头孢哌酮/舒巴坦钠致凝血功能障碍的病例分析

Analysis of 1 Case of Coagulation Dysfunction Caused by Cefoperazone/Sulbactam Sodium

摘要: 临床药师参与1例使用头孢哌酮/舒巴坦钠后引起凝血功能障碍的治疗过程。该患者为84岁男性，既往诊断为高血压、糖尿病。因“黑便、呕咖啡样物质”入院，入院后CT检查提示双肺肺炎，予头孢哌酮钠舒巴坦钠静脉滴注后出现鼻衄，临床药师分析患者既往疾病史以及用药史，考虑出现凝血功能障碍为头孢哌酮钠/舒巴坦钠所致。立即停用头孢哌酮/舒巴坦，并予维生素K1肌肉注射，输注新鲜冰冻血浆200 ml等治疗后凝血功能无异常。临床药师结合患者的病情和用药情况，分析药物使用与药品不良反应之间的关系，为临床合理用药提供参考，保障患者用药安全。

Abstract: Clinical pharmacists participated in the treatment of 1 case of coagulation dysfunction caused by cefoperazone/sulbactam sodium. The patient was an 84-year-old male who was previously diag-nosed with hypertension and diabetes. The patient was admitted to hospital due to “melena and vomiting coffee-like substance”. After admission, CT examination showed bilateral pulmonary pneu- monia. After intravenous infusion of cefoperazone sodium and sulbactam sodium, epistaxis oc-curred. Clinical pharmacists analyzed the patient’s past medical history and medication history, and considered that the coagulation dysfunction was caused by cefoperazone sodium/sulbactam sodi-um. Cefoperazone/sulbactam was immediately discontinued, and vitamin K1 was intramuscularly injected, and 200 ml of fresh frozen plasma was infused. After treatment, there was no abnormal coagulation function. Based on the patient’s condition and medication, clinical pharmacists ana-lyzed the relationship between drug use and adverse drug reactions, so as to provide reference for clinical rational drug use and ensure the safety of drug use.