中医药学结合SSRIs类药物治疗抑郁障碍的研究进展

Progress of Traditional Chinese Medicine Combined with SSRIs in the Treatment of Depressive Disorder

摘要: 抑郁障碍是我国常见的精神疾病之一，目前关于抑郁障碍的治疗，主要是以选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitor, SSRIs)，如氟西汀、帕罗西汀等的药物治疗和以改良无抽搐电休克治疗为代表的物理治疗，同时结合心理治疗。选择性5-羟色胺再摄取抑制剂是一种常用的抗抑郁药物，主要是通过阻断大脑中5-羟色胺的再摄取，增加5-羟色胺在突触间隙中的浓度，从而发挥抗抑郁的作用。与其他抗抑郁药相比，选择性5-羟色胺再摄取抑制剂具有更好的安全性。中医治疗抑郁障碍常选用中医方剂或中成药治疗，中医治疗具有接受度好、疗效可观、不良反应低等优点，而中西医结合治疗抑郁障碍已经成为一种趋势，且疗效好，故本文将就此做一详细综述。

Abstract: Depressive disorder is one of the common mental diseases in China. Currently, the main treatment of depressive disorder is selective serotonin reuptake inhibitor (SSRIs), medications such as fluoxetine, paroxetine, etc., and physical therapy represented by modified non-convulsive electro-convulsive therapy, combined with psychotherapy. Selective serotonin reuptake inhibitors (SSRIs) are commonly used antidepressant drugs that work primarily by blocking serotonin reuptake in the brain and increasing serotonin concentration in the synaptic gap. Selective serotonin reuptake inhibitors have a better safety profile than other antidepressants. Traditional Chinese medicine (TCM) is often used to treat depression disorder. TCM treatment has the advantages of good ac-ceptance, considerable curative effect and low adverse reactions, and the combination of traditional Chinese and Western medicine in the treatment of depression disorder has become a trend with good curative effect, so this article will make a detailed review.