脓毒血症相关生物标志物的研究进展
The Research Progress of Septic Biomarkers
DOI: 10.12677/ACM.2024.142508, PDF,   
作者: 迪力夏提·居马, 玉素甫江·牙库甫*:新疆医科大学第一附属医院急诊创伤中心,新疆 乌鲁木齐
关键词: 脓毒血症生物标志物诊断预后Sepsis Biomarker Diagnosis Prognosis
摘要: 脓毒血症是由感染引起的危及生命的疾病。随着脓毒血症定义的不断演变,对其如何快速识别,用以及时治疗越发重要。由于脓毒血症机制复杂,临床症状及体征缺乏特异性,快速识别脓毒血症在临床工作中成为一项挑战,因此许多脓毒血症相关生物标志物的研究应运而生,但目前仍未能找到理想的生物标志物用来诊断脓毒血症、指导临床的治疗决策以及评估预后。该综述描述了生物标志物的研究现状,通过对现有脓毒血症生物标志物的深入理解,为其运用在脓毒血症的诊疗工作中提供参考。
Abstract: Sepsis is a life-threatening condition caused by infection. As the definition of sepsis continues to evolve, it is becoming more and more important to identify it quickly for prompt treatment. Due to the complex mechanism of sepsis and the lack of specificity of clinical symptoms and signs, rapid identification of sepsis has become a challenge in clinical work. Therefore, many researches on septic biomarkers have emerged at the right time, but ideal biomarkers have not been found to diagnose sepsis, guide clinical treatment decisions and evaluate prognosis. This review describes the current research status of biomarkers for sepsis, and provides references for their application in the diagnosis and treatment of sepsis through in-depth understanding of the existing bi-omarkers.
文章引用:迪力夏提·居马, 玉素甫江·牙库甫. 脓毒血症相关生物标志物的研究进展[J]. 临床医学进展, 2024, 14(2): 3641-3647. https://doi.org/10.12677/ACM.2024.142508

参考文献

[1] Singer, M., Deutschman, C.S., Seymour, C.W., et al. (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315, 801-810. [Google Scholar] [CrossRef] [PubMed]
[2] Weng, L., Xu, Y., Yin, P., et al. (2023) National Incidence and Mortality of Hospitalized Sepsis in China. Critical Care, 27, Article No. 84. [Google Scholar] [CrossRef] [PubMed]
[3] Fleischmann-Struzek, C., Mellhammar, L., Rose, N., et al. (2020) Incidence and Mortality of Hospital- and ICU- Treated Sepsis: Results from an Updated and Expanded Systematic Review and Meta-Analysis. Intensive Care Medicine, 46, 1552-1562. [Google Scholar] [CrossRef] [PubMed]
[4] Song, Q. and Fei, W. (2023) Evaluation of Sepsis-1 and Sep-sis-3 Diagnostic Criteria in Patients with Sepsis in Intensive Care Unit. Journal of Healthcare Engineering, 2023, Article ID: 3794886. [Google Scholar] [CrossRef] [PubMed]
[5] Lippi, G. (2019) Sepsis Biomarkers: Past, Present and Future. Clinical Chemistry and Laboratory Medicine, 57, 1281- 1283. [Google Scholar] [CrossRef] [PubMed]
[6] Aronson, J.K. and Ferner, R.E. (2017) Biomarkers—A General Re-view. Current Protocols in Pharmacology, 76. [Google Scholar] [CrossRef] [PubMed]
[7] Chambliss, A.B., Patel, K., Colón-Franco, J.M., et al. (2023) AACC Guid-ance Document on the Clinical Use of Procalcitonin. The Journal of Applied Laboratory Medicine, 8, 598-634. [Google Scholar] [CrossRef] [PubMed]
[8] Duan, S., Gu, X., Fan, G., et al. (2021) C-Reactive Protein or Procalcitonin Combined with Rhinorrhea for Discrimination of Viral from Bacterial Infections in Hospitalized Adults in Non-Intensive Care Units with Lower Respiratory Tract Infections. BMC Pulmonary Medicine, 21, Article No. 308. [Google Scholar] [CrossRef] [PubMed]
[9] Maigari, I.M., Jibrin, Y.B., Gwalabe, S.A., et al. (2023) Diag-nostic Usefulness of Serum Procalcitonin in Patients with Bacterial Sepsis. Nigerian Journal of Clinical Practice, 26, 1436-1443. [Google Scholar] [CrossRef] [PubMed]
[10] Schuetz, P. (2022) How to Best Use Procalcitonin to Diagnose Infections and Manage Antibiotic Treatment. Clinical Chemistry and Laboratory Medicine, 61, 822-828. [Google Scholar] [CrossRef] [PubMed]
[11] Chanda, D., Kasanga, M., Chanda, R. and Cobelens, F. (2023) C-Reactive Protein: Another Addition to our Armamentarium against Tuberculosis? The Lancet Global Health, 11, E636-E637. [Google Scholar] [CrossRef
[12] Feigin, E., Levinson, T., Witztum, T., et al. (2023) Early Signaling of Bacteremia in Patients Who Present to the Department of Emergency Medicine with Relatively Low C-Reactive Protein (CRP) Concentrations. Clinica Chimica Acta, 547, Article ID: 117451. [Google Scholar] [CrossRef] [PubMed]
[13] Athan, S., Athan, D., Wong, M., et al. (2023) Pathology Stew-ardship in Emergency Departments: A Single-Site, Retrospective, Cohort Study of the Value of C-Reactive Protein in Patients with Suspected Sepsis. Pathology, 55, 673- 679. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, Y.M., Gao, Y., Liang, B.M. and Liang, Z.G. (2023) The Prognostic Value of C-Reactive Protein to Albumin Ratio in Patients with Sepsis: A Systematic Review and Meta-Analysis. The Aging Male, 26, Article ID: 2261540. [Google Scholar] [CrossRef] [PubMed]
[15] Jin, C.X., Hayakawa, T., Ko, S.B.H., et al. (2011) Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases. Internal Medicine, 50, 1507-1516. [Google Scholar] [CrossRef] [PubMed]
[16] Brown, G.D., Willment, J.A. and Whitehead, L. (2018) C-Type Lectins in Immunity and Homeostasis. Nature Reviews Immunology, 18, 374-389. [Google Scholar] [CrossRef] [PubMed]
[17] Pugin, J., Daix, T., Pagani, J.L., et al. (2021) Serial Measurement of Pancreatic Stone Protein for the Early Detection of Sepsis in Intensive Care Unit Patients: A Prospective Multicentric Study. Critical Care, 25, Article No. 151. [Google Scholar] [CrossRef] [PubMed]
[18] De Guadiana-Romualdo, L.G., Albaladejo-Otón, M.D., Berger, M., et al. (2019) Prognostic Performance of Pancreatic Stone Protein in Critically Ill Patients with Sepsis. Biomarkers in Medicine, 13, 1469-1480. [Google Scholar] [CrossRef] [PubMed]
[19] Hu, P., Lu, Y, Hua., Deng, W., et al. (2023) The Critical Role of Pancreatic Stone Protein/Regenerating Protein in Sepsis-Related Multiorgan Failure. Frontiers in Medicine, 10, Article 1172529. [Google Scholar] [CrossRef] [PubMed]
[20] Grebenciucova, E. and VanHaerents, S. (2023) Interleukin 6: At the Interface of Human Health and Disease. Frontiers in Immunology, 14, Article 1255533. [Google Scholar] [CrossRef] [PubMed]
[21] Song, J., Park, D.W., Moon, S., et al. (2019) Diagnostic and Prognostic Value of Interleukin-6, Pentraxin 3, and Procalcitonin Levels among Sepsis and Septic Shock Patients: A Prospective Controlled Study according to the Sepsis-3 Definitions. BMC Infectious Diseases, 19, Article No. 968. [Google Scholar] [CrossRef] [PubMed]
[22] Li, Q., Yan, W., Liu, S. and Li, H. (2023) Study on the Correla-tion and Clinical Significance of T-Lymphocyte Subsets, IL-6 and PCT in the Severity of Patients with Sepsis. Pakistan Journal of Medical Sciences, 39, 227. [Google Scholar] [CrossRef] [PubMed]
[23] Schiff, D.E., Rae, J., Martin, T.R., Davis, B.H. and Curnutte, J.T. (1997) Increased Phagocyte FcγRI Expression and Improved Fcγ-Receptor—Mediated Phagocytosis after in Vivo Re-combinant Human Interferon-γ Treatment of Normal Human Subjects. Blood, 90, 3187-3194. [Google Scholar] [CrossRef
[24] Goswami, D.G., Garcia, L.F., Dodoo, C., et al. (2021) Evaluating the Timeliness and Specificity of CD69, CD64, and CD25 as Biomarkers of Sepsis in Mice. Shock, 55, 507-518. [Google Scholar] [CrossRef
[25] Cong, S., Ma, T.G., Di, X., et al. (2021) Diagnostic Value of Neutrophil CD64, Procalcitonin, and Interleukin-6 in Sepsis: A Meta-Analysis. BMC Infectious Diseases, 21, Article No. 384. [Google Scholar] [CrossRef] [PubMed]
[26] Pham, H.M., Nguyen, D.L.M., Duong, M.C., et al. (2023) Neutrophil CD64—A Prognostic Marker of Sepsis in Intensive Care Unit: A Prospective Cohort Study. Fron-tiers in Medicine, 10, Article 1251221. [Google Scholar] [CrossRef] [PubMed]
[27] Ikegame, A., Kondo, A., Kitaguchi, K., Sasa, K. and Miyoshi, M. (2022) Presepsin Production in Monocyte/Macro- phage-Mediated Phagocytosis of Neutrophil Extracellular Traps. Scientific Reports, 12, Article No. 5978. [Google Scholar] [CrossRef] [PubMed]
[28] Yamamoto, T., Nishimura, T., Kaga, S., et al. (2019) Diagnostic Accuracy of Presepsin for Sepsis by the New Sepsis-3 Definitions. The American Journal of Emergency Medicine, 37, 1936-1941. [Google Scholar] [CrossRef] [PubMed]
[29] Chenevier-Gobeaux, C., Borderie, D., Weiss, N., Mallet-Coste, T. and Claessens Y.E., (2015) Presepsin (SCD14-ST), an Innate Immune Response Marker in Sepsis. Clinica Chimica Acta, 450, 97-103. [Google Scholar] [CrossRef] [PubMed]
[30] Drăgoescu, A.N., et al. (2020) Presepsin as a Potential Prognostic Marker for Sepsis According to Actual Practice Guidelines. Journal of Personalized Medicine, 11, Article 2. [Google Scholar] [CrossRef] [PubMed]
[31] Hashemian, S.M., Pourhanifeh, M.H., Fadaei, S., et al. (2020) Non-Coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis. Nucleic Acids, 21, 51-74. [Google Scholar] [CrossRef] [PubMed]
[32] Sygitowicz, G. and Sitkiewicz, D. (2020) Molecular Mechanisms of Organ Damage in Sepsis: An Overview. The Brazilian Journal of Infectious Diseases, 24, 552-560. [Google Scholar] [CrossRef] [PubMed]
[33] Shen, X., Zhang, J., Huang, Y., et al. (2020) Accuracy of Circu-lating MicroRNAs in Diagnosis of Sepsis: A Systematic Review and Meta-Analysis. Journal of Intensive Care, 8, Ar-ticle No. 84. [Google Scholar] [CrossRef] [PubMed]
[34] Nour, Z., El-Hamamsy, K., Ehsan, I., et al. (2022) MicroRNAs as Potential Diagnostic New Biomarkers in Diagnosis of Sepsis in Pediatric Patients. Reports of Biochem-istry & Molecular Biology, 11, 327-335.
[35] Fatmi, A., Rebiahi, S.A., Chabni, N., et al. (2020) MiRNA-23b as a Biomarker of Culture-Positive Neonatal Sepsis. Molecular Medicine, 26, Article No. 94. [Google Scholar] [CrossRef] [PubMed]
[36] El-Hefnawy, S.M., Mostafa, R.G., Zayat, R.S.E., et al. (2021) Biochemical and Molecular Study on Serum MiRNA- 16a and MiRNA-451 as Neonatal Sepsis Biomarkers. Biochem-istry and Biophysics Reports, 25, Article ID: 100915. [Google Scholar] [CrossRef] [PubMed]
[37] Fouda, E., Midan, D.A.E., Ellaban, R., et al. (2021) The Diag-nostic and Prognostic Role of MiRNA 15b and MiRNA 378a in Neonatal Sepsis. Biochemistry and Biophysics Reports, 26, Article ID: 100988. [Google Scholar] [CrossRef] [PubMed]
[38] Ou, Y., An, R., Wang, H., et al. (2022) Oxidative Stress-Related Circulating MiRNA-27a Is a Potential Biomarker for Diagnosis and Prognosis in Patients with Sepsis. BMC Immunology, 23, Article No. 14. [Google Scholar] [CrossRef] [PubMed]
[39] Agnello, L., Lo, Sasso, B., Bivona, G., et al. (2020) Reference Interval of Monocyte Distribution Width (MDW) in Healthy Blood Donors. Clinica Chimica Acta, 510, 272-277. [Google Scholar] [CrossRef] [PubMed]
[40] Huang, Y.H., Chen, C.J., Shao, S.C., et al. (2023) Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Sys-tematic Review and Meta-Analysis. Critical Care Medicine, 51, e106-e114. [Google Scholar] [CrossRef
[41] Li, M., Qin, Y.J., Zhang, X.L., et al. (2024) A Biomarker Panel of C-Reactive Protein, Procalcitonin and Serum Amyloid a Is a Predictor of Sepsis in Severe Trauma Patients. Scientific Reports, 14, Article No. 628. [Google Scholar] [CrossRef] [PubMed]
[42] Wei, Y., Xiao, P., Wu, B., Chen, F.X. and Shi, X.F. (2023) Significance of STREM-1 and SST2 Combined Diagnosis for Sepsis Detection and Prognosis Prediction. Open Life Sciences, 18, Article ID: 20220639. [Google Scholar] [CrossRef] [PubMed]
[43] Zhao, X.S., Meng, Z.L., Zhang, T., et al. (2023) Combining Serum Procalcitonin Level, Thromboelastography, and Platelet Count to Predict Short-Term Development of Septic Shock in Intensive Care Unit. Current Medical Science, 43, 86-92. [Google Scholar] [CrossRef] [PubMed]
[44] Hausfater, P., Robert Boter, N., Morales Indiano, C., et al. (2021) Monocyte Distribution Width (MDW) Performance as an Early Sepsis Indicator in the Emergency Department: Com-parison with CRP and Procalcitonin in a Multicenter International European Prospective Study. Critical Care, 25, Article No. 227. [Google Scholar] [CrossRef] [PubMed]
[45] Lin, S.F., Lin, H.A., Pan, Y.H. and Hou, S.K. (2022) A Novel Scoring System Combining Modified Early Warning Score with Biomarkers of Monocyte Distribution Width, White Blood Cell Counts, and Neutrophil-to-Lymphocyte Ratio to Improve Early Sepsis Prediction in Older Adults. Clinical Chemistry and Laboratory Medicine, 61, 162-172. [Google Scholar] [CrossRef] [PubMed]