非编码RNA参与食管癌表观遗传修饰
Non-Coding RNA Participates in Epigenetic Modification of Esophageal Cancer
摘要: 食管癌(EC)是目前预后较差的消化道恶性肿瘤,是导致癌症相关死亡的主要原因之一。除基因突变外,许多表观遗传改变,包括DNA甲基化和组蛋白修饰与染色质重塑相关,已被确定参与EC基因表达的调控。近年来,非编码RNA主要是lncRNAs和miRNAs被认为参与EC的表观遗传调控。在这篇综述中,重点描述了与非编码RNA相关的表观遗传过程的新见解及这些非编码RNA在EC的发展和进展中的作用与特征。
Abstract: Esophageal cancer (EC) is a malignant tumor of digestive tract with poor prognosis and is one of the main causes of cancer-related death. In addition to gene mutation, many epigenetic changes, including DNA methylation and histone modification, are associated with chromatin remodeling and have been identified to be involved in the regulation of EC gene expression. In recent years, non-coding RNAs, mainly lncRNAs and miRNAs, are considered to be involved in the epigenetic regulation of EC. In this review, we focus on new insights into epigenetic processes associated with non-coding RNAs, and the roles and characteristics of these non-coding RNAs in the development of EC.
文章引用:阿力木江·木明, 伊地力斯·阿吾提. 非编码RNA参与食管癌表观遗传修饰[J]. 临床医学进展, 2024, 14(2): 3737-3745. https://doi.org/10.12677/ACM.2024.142521

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