单核–巨噬细胞调控脂质代谢的研究进展
Research Progress of Monocytes-Macrophages on Regulation of Lipid Metabolism
DOI: 10.12677/ACM.2024.142544, PDF,   
作者: 冯睿智, 邓国民*:华中科技大学同济医学院附属协和医院风湿免疫科,湖北 武汉
关键词: 脂质代谢单核–巨噬细胞脂质代谢相关疾病免疫代谢Lipid Metabolism Monocytes-Macrophages Lipid Metabolism-Related Diseases Immunometabolism
摘要: 脂质代谢是一个复杂的生理过程,涉及营养调节、激素调节和稳态。脂质代谢紊乱和脂质代谢相关疾病给社会和个人带来巨大的负担,然而这些疾病的具体发病机制尚未明确。免疫代谢领域的发展,揭示了慢性代谢性疾病中复杂的免疫学机制,为这些疾病的治疗开创了很多潜在的新型治疗靶点。单核–巨噬细胞是目前免疫代谢领域中涉及研究最广泛的免疫细胞,其在脂质稳态和脂质代谢紊乱相关疾病中都发挥着重要作用。本文总结了单核–巨噬细胞在调控脂质代谢和促进脂质代谢紊乱中的机制,旨在寻找全新的脂质代谢相关疾病的治疗靶点。
Abstract: Lipid metabolism is a complex physiological process that is involved in nutrient adjustment, hor-mone regulation, and homeostasis. Lipid metabolism disorders and lipid-related diseases bring a huge burden to society and individuals, while the underline mechanism of these diseases is still unrevealed. The development in the field of immunometabolism has revealed the complex immu-nological mechanisms in chronic metabolic diseases and created lots of potential therapeutic tar-gets for the treatment of these diseases. As the most widely studied immune cell in this field, monocytes-macrophages play an important role in both lipid homeostasis and lipid-related dis-eases. In this review, we summarize the role of monocytes-macrophages in lipid homeostasis and lipid metabolism disorders, aiming to find novel therapeutic targets for lipid-related diseases.
文章引用:冯睿智, 邓国民. 单核–巨噬细胞调控脂质代谢的研究进展[J]. 临床医学进展, 2024, 14(2): 3911-3916. https://doi.org/10.12677/ACM.2024.142544

参考文献

[1] Berberich, A.J. and Hegele, R.A. (2022) A Modern Approach to Dyslipidemia. Endocrine Reviews, 43, 611-653. [Google Scholar] [CrossRef] [PubMed]
[2] Li, Y., et al. (2017) A Global Perspective on FOXO1 in Lipid Me-tabolism and Lipid-Related Diseases. Progress in Lipid Research, 66, 42-49. [Google Scholar] [CrossRef] [PubMed]
[3] Hotamisligil, G.S. (2017) Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity, 47, 406-420. [Google Scholar] [CrossRef] [PubMed]
[4] Santacruz-Calvo, S., et al. (2022) Adaptive Immune Cells Shape Obesity-Associated Type 2 Diabetes Mellitus and Less Prominent Comorbidities. Nature Reviews Endocrinology, 18, 23-42. [Google Scholar] [CrossRef] [PubMed]
[5] Krenkel, O. and Tacke, F. (2017) Liver Macrophages in Tissue Homeostasis and Disease. Nature Reviews Immunology, 17, 306-321. [Google Scholar] [CrossRef] [PubMed]
[6] Guilliams, M. and Scott, C.L. (2022) Liver Macrophages in Health and Disease. Immunity, 55, 1515-1529. [Google Scholar] [CrossRef] [PubMed]
[7] Chavakis, T., Alexaki, V.I. and Ferrante Jr., A.W. (2023) Macrophage Function in Adipose Tissue Homeostasis and Metabolic Inflammation. Nature Immunology, 24, 757-766. [Google Scholar] [CrossRef] [PubMed]
[8] Guilliams, M., Mildner, A. and Yona, S. (2018) Developmental and Functional Heterogeneity of Monocytes. Immunity, 49, 595-613. [Google Scholar] [CrossRef] [PubMed]
[9] Kohlgruber, A.C., LaMarche, N.M. and Lynch, L. (2016) Adipose Tissue at the Nexus of Systemic and Cellular Immunometabolism. Seminars in Immunology, 28, 431-440. [Google Scholar] [CrossRef] [PubMed]
[10] Brestoff, J.R. and Artis, D. (2015) Immune Regulation of Met-abolic Homeostasis in Health and Disease. Cell, 161, 146-160. [Google Scholar] [CrossRef] [PubMed]
[11] Jaitin, D.A., et al. (2019) Lipid-Associated Macrophages Control Metabolic Homeostasis in A Trem2-Dependent Manner. Cell, 178, 686-698.E14. [Google Scholar] [CrossRef] [PubMed]
[12] Rao, R.R., et al. (2014) Meteorin-Like Is a Hormone That Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell, 157, 1279-1291. [Google Scholar] [CrossRef] [PubMed]
[13] Knights, A.J., et al. (2021) Acetylcholine-Synthesizing Macrophag-es in Subcutaneous Fat Are Regulated by β2-Adrenergic Signaling. EMBO Journal, 40, e106061. [Google Scholar] [CrossRef] [PubMed]
[14] Wang, Y.N., et al. (2021) Slit3 Secreted From M2-Like Macro-phages Increases Sympathetic Activity and Thermogenesis in Adipose Tissue. Nature Metabolism, 3, 1536-1551. [Google Scholar] [CrossRef] [PubMed]
[15] Trefts, E., Gannon, M. and Wasserman, D.H. (2017) The Liver. Current Biology, 27, R1147-R1151. [Google Scholar] [CrossRef] [PubMed]
[16] Racanelli, V. and Rehermann, B. (2006) The Liver as an Immu-nological Organ. Hepatology, 43, S54-S62. [Google Scholar] [CrossRef] [PubMed]
[17] Remmerie, A., et al. (2020) Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver. Immunity, 53, 641-657.E14. [Google Scholar] [CrossRef] [PubMed]
[18] Kaffe, E., et al. (2023) Humanized Mouse Liver Reveals Endo-thelial Control of Essential Hepatic Metabolic Functions. Cell, 186, 3793-3809.E26. [Google Scholar] [CrossRef] [PubMed]
[19] BlÉRiot, C., et al. (2021) A Subset of Kupffer Cells Regulates Metabolism through the Expression of CD36. Immunity, 54, 2101-2116.E6. [Google Scholar] [CrossRef] [PubMed]
[20] Loft, A., et al. (2022) A Macrophage-Hepatocyte Glucocorti-coid Receptor Axis Coordinates Fasting Ketogenesis. Cell Metabolism, 34, 473-486.E9. [Google Scholar] [CrossRef] [PubMed]
[21] Sun, K., Kusminski, C.M. and Scherer, P.E. (2011) Adipose Tissue Remodeling and Obesity. Journal of Clinical Investigation, 121, 2094-2101. [Google Scholar] [CrossRef
[22] Kratz, M., et al. (2014) Metabolic Dysfunction Drives A Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages. Cell Metabolism, 20, 614-625. [Google Scholar] [CrossRef] [PubMed]
[23] Laurencikiene, J., et al. (2007) NF-κB Is Important for TNF-α-Induced Lipolysis in Human Adipocytes. Journal of Lipid Research, 48, 1069-1077. [Google Scholar] [CrossRef
[24] Ruan, H., et al. (2002) Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes: Nuclear Factor-κB Activation by TNF-α Is Obligatory. Diabetes, 51, 1319- 1336. [Google Scholar] [CrossRef] [PubMed]
[25] Gao, D., et al. (2014) Interleukin-1β Mediates Macrophage-Induced Impairment of Insulin Signaling in Human Primary Adipocytes. American Journal of Physiology-Endocrinology and Metabolism, 307, E289-E304. [Google Scholar] [CrossRef] [PubMed]
[26] Chen, J., et al. (2021) Kdm6a Suppresses the Alternative Acti-vation of Macrophages and Impairs Energy Expenditure in Obesity. Cell Death & Differentiation, 28, 1688-1704. [Google Scholar] [CrossRef] [PubMed]
[27] Shan, B., et al. (2017) The Metabolic ER Stress Sensor IRE1α Suppresses Alternative Activation of Macrophages and Impairs Energy Expenditure in Obesity. Nature Immunology, 18, 519-529. [Google Scholar] [CrossRef] [PubMed]
[28] Ouchi, N., et al. (2011) Adipokines in Inflammation and Metabolic Disease. Nature Reviews Immunology, 11, 85-97. [Google Scholar] [CrossRef] [PubMed]
[29] Sarraf, P., et al. (1997) Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia. Journal of Experimental Medicine, 185, 171-175. [Google Scholar] [CrossRef] [PubMed]
[30] Li, Y., et al. (2003) Differential Expression of Adrenomedullin and Resistin in 3T3-L1 Adipocytes Treated with Tumor Necrosis Factor-α. European Journal of Endocrinology, 149, 231-238. [Google Scholar] [CrossRef] [PubMed]
[31] Fasshauer, M., et al. (2003) Adiponectin Gene Expression and Secretion Is Inhibited by Interleukin-6 in 3T3-L1 Adipocytes. Biochemical and Biophysical Research Communications, 301, 1045-1050. [Google Scholar] [CrossRef
[32] Huby, T. and Gautier, E.L. (2022) Immune Cell-Mediated Features of Non-Alcoholic Steatohepatitis. Nature Reviews Immunology, 22, 429-443. [Google Scholar] [CrossRef] [PubMed]
[33] Kazankov, K., et al. (2019) The Role of Macrophages in Non-alcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. Nature Reviews Gastroenterology & Hepatology, 16, 145-159. [Google Scholar] [CrossRef] [PubMed]
[34] Tosello-Trampont, A.C., et al. (2012) Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-Induced Mouse Model through Tumor Necrosis Factor-α Production. Journal of Biological Chemistry, 287, 40161-40172. [Google Scholar] [CrossRef
[35] Nonogaki, K., et al. (1995) Interleukin-6 Stimulates Hepatic Tri-glyceride Secretion in Rats. Endocrinology, 136, 2143- 2149. [Google Scholar] [CrossRef] [PubMed]
[36] Bijnen, M., et al. (2018) Adipose Tissue Macrophages Induce Hepatic Neutrophil Recruitment and Macrophage Accumulation in Mice. Gut, 67, 1317-1327. [Google Scholar] [CrossRef] [PubMed]
[37] Huang, W., et al. (2010) Depletion of Liver Kupffer Cells Pre-vents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance. Diabetes, 59, 347-357. [Google Scholar] [CrossRef] [PubMed]