全身因素影响角膜生物力学的研究进展

Advances in the Study of Systemic Factors Affecting Corneal Biomechanics

摘要: 作为眼的重要组成部分，角膜不仅具有屈光特性，还有着独特的生物力学特性。既往角膜生物力学特性主要用于排除角膜手术相关禁忌症，预测角膜手术疗效和预后、扩张性角膜疾病的发生和发展，协助诊治青光眼及近视等眼科疾病，随着国内外团队的研究不断深入，研究者们将角膜生物力学与临床相结合，发现全身因素的改变也可能影响角膜的生物力学特性，如年龄、糖尿病、甲状腺疾病、性激素、结缔组织疾病等。本文将已发表的关于角膜生物力学与全身因素改变的研究结果进行了综述。

Abstract: As an important part of the eye, the cornea has not only refractive properties but also unique bio-mechanical properties. Previously, corneal biomechanical properties were mainly used to rule out contraindications related to corneal surgery, predict the efficacy and prognosis of corneal surgery, the occurrence and development of dilated corneal disease, and assist in the diagnosis and treat-ment of ophthalmic diseases such as glaucoma and myopia, etc. As the research of the domestic and international teams continues to deepen, researchers have combined corneal biomechanics with clinical, and found that the changes in the systemic factors may also affect the cornea’s biomechani-cal properties, such as age, diabetes mellitus, thyroid disease, connective tissue disease, and so on. This article summarizes the results of published studies on corneal biomechanics and systemic changes.