医用聚醚醚酮抗菌改性的研究进展
Research Progress of Antimicrobial Modification of Medical Polyetheretherketone
DOI: 10.12677/ACM.2024.142563, PDF,   
作者: 刘 娟, 徐朕钰, 徐国强*:新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科,新疆 乌鲁木齐;新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐;马乐天:新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐;新疆医科大学第一附属医院(附属口腔医院)颌面肿瘤外科,新疆 乌鲁木齐
关键词: 聚醚醚酮抗菌改性涂层改性化学改性Polyetheretherketone Antimicrobial Modification Coating Modification Chemical Modification
摘要: 聚醚醚酮(Polyetheretherketone, PEEK)是一种新兴的有机高分子材料,在口腔修复和骨科植入物领域颇有前景。本文主要综述了改善聚醚醚酮抗菌性的几种方法,如化学改性、表面涂层负载改性、物理改性,并提出了其在抗菌改性方面仍存在的问题及挑战。
Abstract: Polyetheretherketone (PEEK) is an emerging organic polymer material, which is promising in the field of oral prosthetic and orthopedic implants. This paper mainly reviews several methods to im-prove the antimicrobial properties of polyetheretherketone, such as chemical modification, surface coating loading modification, and physical modification, and presents the problems and challenges that still exist in its antimicrobial modification.
文章引用:刘娟, 徐朕钰, 马乐天, 徐国强. 医用聚醚醚酮抗菌改性的研究进展[J]. 临床医学进展, 2024, 14(2): 4059-4066. https://doi.org/10.12677/ACM.2024.142563

参考文献

[1] Panayotov, I.V., Orti, V., Cuisinier, F., et al. (2016) Polyetheretherketone (PEEK) for Medical Applications. Journal of Materials Science: Materials in Medicine, 27, Article No. 118. [Google Scholar] [CrossRef] [PubMed]
[2] Kurtz, S.M. and Devine, J.N. (2007) PEEK Biomaterials in Trau-ma, Orthopedic, and Spinal Implants. Biomaterials, 28, 4845-4869. [Google Scholar] [CrossRef] [PubMed]
[3] Najeeb, S., Zafar, M.S., Khurshid, Z. and Siddiqui, F. (2016) Applications of Polyetheretherketone (PEEK) in Oral Implantology and Prosthodontics. Journal of Prosthodontic Research, 60, 12-19. [Google Scholar] [CrossRef] [PubMed]
[4] Azhar, I.S., Syaharani, R.G., Smeer, V.S., et al. (2023) Polyether Ether Ketones (PEEK): Properties and Applications as Implants for Alternative Dentistry Materials: A Narrative Review. Journal of International Oral Health, 15, 28-33. [Google Scholar] [CrossRef
[5] Moharil, S., Reche, A. and Durge, K. (2023) Polyetheretherketone (PEEK) as a Biomaterial: An Overview. Cureus, 15, e44307. [Google Scholar] [CrossRef] [PubMed]
[6] Wiessner, A., Wassmann, T., Wiessner, J.M., et al. (2023) In Vivo Biofilm Formation on Novel PEEK, Titanium, and Zirconia Im-plant Abutment Materials. International Journal of Molecular Sciences, 24, Article 1779. [Google Scholar] [CrossRef] [PubMed]
[7] Brum, R.S., Labes, L.G., Volpato, C.Â.M., et al. (2020) Strategies to Reduce Biofilm Formation in PEEK Materials Applied to Implant Dentistry—A Comprehensive Review. Antibiotics, 9, Article 609. [Google Scholar] [CrossRef] [PubMed]
[8] Jin, X., Bishop, M.T., Ellis, T.S., et al. (1985) A Sulphonated Poly(Aryl Ether Ketone). British Polymer Journal, 17, 4-10. [Google Scholar] [CrossRef
[9] Shibuya, N. and Porter, R.S. (1992) Kinetics of PEEK Sulfonation in Concentrated Sulfuric Acid. Macromolecules, 25, 6495-6499. [Google Scholar] [CrossRef
[10] Wang, W., Luo, C.J., Huang, J., et al. (2019) PEEK Surface Modifica-tion by Fast Ambient-Temperature Sulfonation for Bone Implant Applications. Journal of the Royal Society Interface, 16, Article 20180955. [Google Scholar] [CrossRef] [PubMed]
[11] Ouyang, L., Zhao, Y., Jin, G., et al. (2016) Influence of Sulfur Content on Bone Formation and Antibacterial Ability of Sulfonated PEEK. Biomaterials, 83, 115-126. [Google Scholar] [CrossRef] [PubMed]
[12] Montero, J.F.D., Tajiri, H.A., Barra, G.M.O., et al. (2017) Biofilm Behavior on Sulfonated Poly(Ether-Ether-Ketone) (sPEEK). Materials Science and Engineering: C, 70, 456-460. [Google Scholar] [CrossRef] [PubMed]
[13] Bhattacharya, A. and Misra, B.N. (2004) Grafting: A Versatile Means to Modify Polymers: Techniques, Factors and Applications. Progress in Polymer Science, 29, 767-814. [Google Scholar] [CrossRef
[14] 白涧飞, 陈良, 王德飞, 等. 聚醚醚酮植入材料接枝改性的研究进展[J]. 中华老年口腔医学杂志, 2019, 17(1): 51-54+62.
[15] Ma, T., Zhang, J., Sun, S., et al. (2023) Current Treatment Methods to Improve the Bioactivity and Bonding Strength of PEEK for Dental Application: A Sys-tematic Review. European Polymer Journal, 183, Article 111757. [Google Scholar] [CrossRef
[16] 孙会娟. 光诱导自引发接枝聚合PEEK植入体研究进展[J]. 工程塑料应用, 2021, 49(4): 153-156.
[17] Hu, C.-C., Kumar, S.R., Vi, T.T.T., et al. (2021) Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-Dimethylaminopropyl)Carbodiimide: Surface Properties and Antibacterial Activity. International Journal of Molecular Sciences, 23, Article 359. [Google Scholar] [CrossRef] [PubMed]
[18] Chen, Y., Chen, Y., Han, T., et al. (2023) Enhanced Osteogenic and Antibacterial Properties of Polyetheretherketone by Ultraviolet-Initiated Grafting Polymerization of a Gelatin Methacrylo-yl/Epsilon-Poly-L-Lysine/Laponite Hydrogel Coating. Journal of Biomedical Materials Research Part A, 111, 1808-1821. [Google Scholar] [CrossRef] [PubMed]
[19] Buwalda, S., Rotman, S., Eglin, D., et al. (2020) Synergistic Anti-Fouling and Bactericidal Poly(Ether Ether Ketone) Surfaces via a One-Step Photomodification. Materials Science and Engineer-ing: C, 111, Article 110811. [Google Scholar] [CrossRef] [PubMed]
[20] Meng, X., Zhang, J., Chen, J., et al. (2020) KR-12 Coating of Polyetheretherketone (PEEK) Surface via Polydopamine Improves Osteointegration and Antibacterial Activity In Vivo. Journal of Materials Chemistry B, 8, 10190-10204. [Google Scholar] [CrossRef
[21] Xue, Z., Wang, Z., Huang, J., et al. (2020) Rapid Construction of Poly-etheretherketone (PEEK) Biological Implants Incorporated with Brushite (CaHPO4•2H2O) and Antibiotics for An-ti-Infection and Enhanced Osseointegration. Materials Science and Engineering: C, 111, Article 110782. [Google Scholar] [CrossRef] [PubMed]
[22] Yuan, X., Ouyang, L., Luo, Y., et al. (2019) Multifunctional Sul-fonated Polyetheretherketone Coating with Beta-Defensin-14 for Yielding Durable and Broad-Spectrum Antibacterial Activity and Osseointegration. Acta Biomaterialia, 86, 323-337. [Google Scholar] [CrossRef] [PubMed]
[23] Xu, X., Li, Y., Wang, L., et al. (2019) Triple-Functional Polyeth-eretherketone Surface with Enhanced Bacteriostasis and Anti-Inflammatory and Osseointegrative Properties for Implant Application. Biomaterials, 212, 98-114. [Google Scholar] [CrossRef] [PubMed]
[24] He, X., Deng, Y., Yu, Y., et al. (2019) Drug-Loaded/Grafted Peptide-Modified Porous PEEK to Promote Bone Tissue Repair and Eliminate Bacteria. Colloids and Surfaces B: Biointerfaces, 181, 767-777. [Google Scholar] [CrossRef] [PubMed]
[25] Lau, N.-C., Tsai, M.-H., Chen, D.W., et al. (2019) Preparation and Characterization for Antibacterial Activities of 3D Printing Polyetheretherketone Disks Coated with Various Ratios of Ampicillin and Vancomycin Salts. Applied Sciences, 10, Article 97. [Google Scholar] [CrossRef
[26] Jin, G., Cao, H., Qiao, Y., et al. (2014) Osteogenic Activity and Anti-bacterial Effect of Zinc Ion Implanted Titanium. Colloids and Surfaces B: Biointerfaces, 117, 158-165. [Google Scholar] [CrossRef] [PubMed]
[27] Wang, X., Zhu, H., Yang, F., et al. (2009) Biofilm-Engineered Nanostructures. Advanced Materials, 21, 2815-2818. [Google Scholar] [CrossRef
[28] Yu, F., Fang, X., Jia, H., et al. (2016) Zn or O? An Atomic Level Comparison on Antibacterial Activities of Zinc Oxides. Chemistry—A European Journal, 22, 8053-8058. [Google Scholar] [CrossRef] [PubMed]
[29] Ye, J., Deng, J., Chen, Y., et al. (2019) Cicada and Catkin Inspired Dual Biomimetic Antibacterial Structure for the Surface Modification of Implant Material. Biomaterials Science, 7, 2826-2832. [Google Scholar] [CrossRef
[30] Yang, S., Yu, W., Zhang, J., et al. (2022) The Antibacteri-al Property of Zinc Oxide/Graphene Oxide Modified Porous Polyetheretherketone against S. sanguinis, F. nucleatum and P. gingivalis. Biomedical Materials, 17, Article No. 2. [Google Scholar] [CrossRef
[31] Deng, L., Deng, Y. and Xie, K. (2017) AgNPs-Decorated 3D Printed PEEK Implant for Infection Control and Bone Repair. Colloids and Surfaces B: Biointerfaces, 160, 483-492. [Google Scholar] [CrossRef] [PubMed]
[32] Yang, X., Chai, H., Guo, L., et al. (2021) In Situ Preparation of Porous Metal-Organic Frameworks ZIF-8@Ag on Poly-Ether-Ether-Ketone with Synergistic Antibacterial Activity. Colloids and Surfaces B: Biointerfaces, 205, Article 111920. [Google Scholar] [CrossRef] [PubMed]
[33] Liu, W., Li, J., Cheng, M., et al. (2019) A Surface-Engineered Polyetheretherketone Biomaterial Implant with Direct and Immunoregulatory Antibacterial Activity against Methicil-lin-Resistant Staphylococcus aureus. Biomaterials, 208, 8-20. [Google Scholar] [CrossRef] [PubMed]
[34] Li, J., Qian, S., Ning, C. and Liu, X. (2016) rBMSC and Bacterial Responses to Isoelastic Carbon Fiber-Reinforced Poly(Ether-Ether-Ketone) Modified by Zirconium Implanta-tion. Journal of Materials Chemistry B, 4, 96-104. [Google Scholar] [CrossRef
[35] Deng, Y., Yang, L., Huang, X., et al. (2018) Dual Ag/ZnO-Decorated Micro-/Nanoporous Sulfonated Polyetheretherketone with Superior Antibacterial Capability and Biocompatibility via Layer-by-Layer Self-Assembly Strategy. Macromolecular Bioscience, 18, Article 1800028. [Google Scholar] [CrossRef] [PubMed]
[36] Yan, J., Xia, D., Zhou, W., et al. (2020) pH-Responsive Silk Fibro-in-Based CuO/Ag Micro/Nano Coating Endows Polyetheretherketone with Synergistic Antibacterial Ability, Osteogene-sis, and Angiogenesis. Acta Biomaterialia, 115, 220-234. [Google Scholar] [CrossRef] [PubMed]
[37] Yan, J., Zhou, W., Jia, Z., et al. (2018) Endowing Polyetheretherketone with Synergistic Bactericidal Effects and Improved Oste-ogenic Ability. Acta Biomaterialia, 79, 216-229. [Google Scholar] [CrossRef] [PubMed]
[38] Liu, C., Bai, J., Wang, Y., et al. (2021) The Effects of Three Cold Plasma Treatments on the Osteogenic Activity and Antibacterial Prop-erty of PEEK. Dental Materials, 37, 81-93. [Google Scholar] [CrossRef] [PubMed]
[39] Zhang, Y., Wu, H., Yuan, B., et al. (2021) Enhanced Osteogenic Activity and Antibacterial Performance in Vitro of Polyetheretherketone by Plasma-Induced Graft Polymerization of Acrylic Acid and Incorporation of Zinc Ions. Journal of Materials Chemistry B, 9, 7506-7515. [Google Scholar] [CrossRef
[40] Wan, R., Wang, X., Lei, L., et al. (2022) Enhanced An-ti-Microbial Activity and Osseointegration of Ta/Cu Co-Implanted Polyetheretherketone. Colloids and Surfaces B: Bioin-terfaces, 218, Article 112719. [Google Scholar] [CrossRef] [PubMed]
[41] Chen, T., Chen, Q., Fu, H., et al. (2021) Construction and Performance Evaluation of a Sustained Release Implant Material Polyetheretherketone with Antibacterial Properties. Ma-terials Science and Engineering: C, 126, Article 112109. [Google Scholar] [CrossRef] [PubMed]
[42] Mo, S., Mehrjou, B., Tang, K., et al. (2019) Dimension-al-Dependent Antibacterial Behavior on Bioactive Micro/Nano Polyetheretherketone (PEEK) Arrays. Chemical Engi-neering Journal, 392, Article 123736. [Google Scholar] [CrossRef
[43] 侯中中, 邹华. 聚醚醚酮材料抗菌改性的研究进展[J]. 广州化学, 2023, 48(2): 25-35.
[44] Liu, X., Gan, K., Liu, H., et al. (2017) Antibacterial Properties of Nano-Silver Coated PEEK Prepared through Magnetron Sputtering. Dental Materials, 33, e348-e360. [Google Scholar] [CrossRef] [PubMed]