膀胱部分切除术在肌层浸润性膀胱癌治疗中的作用分析

Analysis of the Role of Partial Cystectomy in the Treatment of Muscle Layer Invasive Bladder Cancer

摘要: 目的：分析肌层浸润性膀胱癌治疗期间膀胱部分切除术的综合应用价值。方法：我院在2019年2月到2022年2月期间接收100例肌层浸润性膀胱癌患者，遵循随机双盲原则将患者分为对照组、观察组，前者50例使用根治性膀胱全切术予以治疗，后者50例采取膀胱部分切除术，分析两组患者综合治疗效果、手术相关指标、并发症、随访期间复发情况。结果：观察组患者总缓解率与对照组差异较小，无统计学意义(P > 0.05)；观察组患者常规手术指标(术中出血量、手术时间、导尿管留置时间、住院时间)均小于对照组；观察组患者术后相关并发症总发生率小于对照组，上述不同指标差异明显，有统计学意义(P < 0.05)；两组患者术后10个月内的复发率差异较小，无统计学意义(P > 0.05)；观察组患者术后随访期间生活质量评分高于对照组，存在统计学意义(P < 0.05)。结论：肌层浸润性膀胱癌治疗中采取膀胱部分切除术可保证患者的整体疗效，同时对患者手术指标优化、并发症预防以及术后生活质量均有促进作用，为不同患者的远期预后奠定基础。

Abstract: Objective: To analyze the comprehensive application value of partial cystectomy during the treat-ment of muscle layer invasive bladder cancer. Methods: From February 2019 to February 2022, our hospital received 100 patients with myometrial invasive bladder cancer. The patients were randomly divided into a control group and an observation group according to the double-blind principle. The former 50 patients were treated with radical total cystectomy, and the latter 50 pa-tients were treated with partial cystectomy. The comprehensive treatment effect, surgical related indicators, complications, and recurrence during follow-up were analyzed between the two groups. Result: The total remission rate of the observation group patients was relatively small compared to the control group, and there was no statistically significant difference (P > 0.05); The routine surgical indicators (intraoperative blood loss, surgical time, catheterization time, and hospital stay) of the observation group were all lower than those of the control group; The total incidence of postoperative complications in the observation group was lower than that in the control group, and the differences in the above different indicators were significant and statistically significant (P < 0.05); The difference in recurrence rate between the two groups of patients within 10 months after surgery was small and not statistically significant (P > 0.05); The quality of life score of the observation group patients during postoperative follow-up was higher than that of the control group, with statistical significance (P < 0.05). Conclusion: Partial cystectomy in the treatment of myometrial invasive bladder cancer can ensure the overall efficacy of patients, and promote the optimization of surgical indicators, prevention of complications and postoperative quality of life of patients, laying the foundation for long-term prognosis of different patients.