2型糖尿病与胰腺癌术后并发症及预后研究进展

Research Progress on Postoperative Complications and Prognosis of Type 2 Diabetes and Pancreatic Cancer

摘要: 目的：2型糖尿病(T2DM)与胰腺癌(PC)之间的关系很复杂，目前国内外已对该研究相关方面进行详细讨论，但结果仍有争议，为进一步探讨T2DM与PC预后的关系，结合目前国内外的近期研究，总结其中的发生机制及相关研究进展。方法：检索近年国内外有关2型糖尿病与胰腺癌相关研究并进行综述。结果：T2DM与PC术后并发症的研究相对较少，是否影响胰瘘和胃排空延迟等并发症国内外研究存在较大争议，但是可以明确T2DM是PC预后的不利因素，并且高血糖状态不利于PC的预后，控制血糖是延长预后的重要环节。结论：T2DM对PC术后并发症的发生仍有争议，在胰腺外科临床治疗方面有借鉴价值和指导意义，明确T2DM与PC术后并发症的关系尚需制定更加详细的研究分组，进一步增加数据量研究。

Abstract: Objective: The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is very complicated. At present, the relevant aspects of this study have been discussed in detail at home and abroad, but the results are still controversial. In order to further explore the relationship between T2DM and PC prognosis, combined with recent studies at home and abroad, the pathogenesis and related research progress are summarized. Method: The research on type 2 dia-betes mellitus and pancreatic cancer at home and abroad in recent years was reviewed. Results: There are relatively few studies on postoperative complications of T2DM and PC, and there are great controversies in domestic and foreign studies on whether it affects complications such as pancreatic fistula and delayed gastric empting. However, it is clear that T2DM is an unfavorable factor for the prognosis of PC, and hyperglycemia is not conducive to the prognosis of PC, and blood glucose control is an important link to prolong the prognosis. Conclusion: T2DM is still controversial in the occurrence of postoperative complications of PC, and it has reference value and guiding significance in the clinical treatment of pancreatic surgery. To clarify the relationship between T2DM and postoperative complications of PC, more detailed research groups need to be developed to further increase the amount of data.