硫氧还蛋白与泌尿系结石疾病的研究进展
Research Progress on Thioredoxin and Urinary Stone Diseases
DOI: 10.12677/ACM.2024.142580, PDF,   
作者: 麦吾拉江·买合木提:新疆医科大学第二临床医学院,新疆 乌鲁木齐;木拉提·马合木提*:新疆医科大学第二附属医院泌尿外科,新疆 乌鲁木齐
关键词: 硫氧还蛋白泌尿系结石氧化应激Nrf2信号通路Thioredoxin Urinary Stones Oxidative Stress Nrf2 Signaling Pathway
摘要: 泌尿系结石疾病是一种非常常见的外科疾病,影响着全球10%的人口,而且泌尿系结石的发病率和患病率每年都在增加。目前,尿路结石的治疗方法很多,但其机制尚未完全阐明。主流观点认为氧化应激是结石形成及后续发展的关键。硫氧还蛋白系统是广泛存在于各种细胞中的一种抗氧化系统,在控制氧化应激中发挥着重要作用。据此,我们推测硫氧还蛋白可能在泌尿系结石中发挥着生物学作用。本文就Trx在泌尿系结石形成机制中的研究进展作一综述。
Abstract: Urolithiasis is a very common surgical disease, affecting 10% of the global population, and the incidence and prevalence of urolithiasis are increasing every year. Nowadays, there are many treatments for urinary calculi, but the mechanism of urolithiasis has not been fully elucidated. The mainstream view is that oxidative stress is the key point in the formation and follow-up development of stones. Thioredoxin system is an antioxidant system that widely exists in all kinds of cells and plays an important role in controlling oxidative stress. It is speculated that thioredoxin may play a biological role in urinary calculi. This article reviews the research pro-gress of Trx in the mechanism of urolithiasis.
文章引用:麦吾拉江·买合木提, 木拉提·马合木提. 硫氧还蛋白与泌尿系结石疾病的研究进展[J]. 临床医学进展, 2024, 14(2): 4190-4195. https://doi.org/10.12677/ACM.2024.142580

参考文献

[1] Lang, J., Narendrula, A., El-Zawahry, A., et al. (2022) Global Trends in Incidence and Burden of Urolithiasis from 1990 to 2019: An Analysis of Global Burden of Disease Study Data. European Urology Open Science, 35, 37-46. [Google Scholar] [CrossRef] [PubMed]
[2] Chewcharat, A. and Curhan, G. (2021) Trends in the Prev-alence of Kidney Stones in the United States from 2007 to 2016. Urolithiasis, 49, 27-39. [Google Scholar] [CrossRef] [PubMed]
[3] Wang, W., Fan, J., Huang, G., et al. (2017) Prevalence of Kidney Stones in Mainland China: A Systematic Review. Scientific Reports, 7, Article No. 41630. [Google Scholar] [CrossRef] [PubMed]
[4] Ye, Z., Zeng, G., Yang, H., et al. (2020) The Status and Characteristics of Urinary Stone Composition in China. BJU International, 125, 801-809. [Google Scholar] [CrossRef] [PubMed]
[5] Wang, Z., Zhang, Y., Zhang, J., et al. (2021) Recent Advances on the Mechanisms of Kidney Stone Formation (Review). International Journal of Molecular Medicine, 48, Article 149. [Google Scholar] [CrossRef] [PubMed]
[6] Stamatelou, K. and Goldfarb, D.S. (2023) Epidemiology of Kidney Stones. Healthcare, 11, Article 424. [Google Scholar] [CrossRef] [PubMed]
[7] Wagner, C.A. (2021) Etiopathogenic Factors of Urolithiasis. Archivos Españoles de Urología, 74, 16-23.
[8] Felber, J.G., Kitowski, A., Zeisel, L., et al. (2023) Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Appli-cations to Seco-Duocarmycins Targeting the Thioredoxin System. ACS Central Science, 9, 763-76. [Google Scholar] [CrossRef] [PubMed]
[9] Jastrząb, A. and Skrzydlewska, E. (2020) Thioredox-in-Dependent System. Application of Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 36, 362-371. [Google Scholar] [CrossRef] [PubMed]
[10] Hawkes, H.J.K., Karlenius, T.C. and Tonis-sen, K.F. (2014) Regulation of the Human Thioredoxin Gene Promoter and Its Key Substrates: A Study of Func-tional and Putative Regulatory Elements. Biochimica et Biophysica Acta (BBA)— General Subjects, 1840, 303-314. [Google Scholar] [CrossRef] [PubMed]
[11] Patwardhan, R.S., Sharma, D. and Sandur, S.K. (2022) Thioredoxin Reductase: An Emerging Pharmacologic Target for Radiosensitization of Cancer. Translational On-cology, 17, Article ID: 101341. [Google Scholar] [CrossRef] [PubMed]
[12] Medali, T., Couchie, D., Mougenot, N., et al. (2023) Thi-oredoxin-1 and Its Mimetic Peptide Improve Systolic Cardiac Function and Remodeling after Myocardial Infarction. The FASEB Journal, 38, e23291. [Google Scholar] [CrossRef
[13] Hasan, A.A., Kalinina, E., Tatarskiy, V. and Shtil, A. (2022) The Thioredoxin System of Mammalian Cells and Its Modulators. Biomedicines, 10, Article 1757. [Google Scholar] [CrossRef] [PubMed]
[14] Pan, M., Zhang, F., Qu, K., et al. (2022) TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook. Oxidative Medicine and Cellular Longevity, 2022, Ar-ticle ID: 7805115. [Google Scholar] [CrossRef] [PubMed]
[15] Kansal, H., Chopra, V., Garg, K. and Sharma, S. (2023) Role of Thioredoxin in Chronic Obstructive Pulmonary Disease (COPD): A Promising Future Target. Res-piratory Research, 24, Article No. 295. [Google Scholar] [CrossRef] [PubMed]
[16] Pan, Y., Lu, Y., Zhou, J.D., et al. (2022) Prospect of Thi-oredoxin as a Possibly Effective Tool to Combat OSAHS. Sleep and Breathing, 27, 421-429. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, Y., Xue, N., Zhang, B., et al. (2022) Role of Thiore-doxin-1 and Its Inducers in Human Health and Diseases. European Journal of Pharmacology, 919, Article ID: 174756. [Google Scholar] [CrossRef] [PubMed]
[18] Zhu, M., Dagah, O.M.A., Silaa, B.B., et al. (2023) Thioredoxin/Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Po-tential. Antioxidants, 12, Article 1680. [Google Scholar] [CrossRef] [PubMed]
[19] Halliwell, B. (2023) Understanding Mechanisms of Antioxidant Action in Health and Disease. Nature Reviews Molecular Cell Biology, 25, 13-33. [Google Scholar] [CrossRef] [PubMed]
[20] Ulasov, A.V., Rosenkranz, A.A., Georgiev, G.P., et al. (2022) Nrf2/Keap1/ARE Signaling: Towards Specific Regulation. Life Sciences, 291, Article ID: 120111. [Google Scholar] [CrossRef] [PubMed]
[21] Ghareeb, H. and Metanis, N. (2020) The Thioredoxin System: A Promising Target For Cancer Drug Development. Chemistry: A European Journal, 26, 10175-10184. [Google Scholar] [CrossRef] [PubMed]
[22] Tian, Z.K., Zhang, Y.J., Feng, Z.J., et al. (2021) Nephropro-tective Effect of Gastrodin against Lead-Induced Oxidative Stress and Inflammation in Mice by the GSH, Trx, Nrf2 Antioxidant System, and the HMGB1 Pathway. Toxicology Research, 10, 249-263. [Google Scholar] [CrossRef] [PubMed]
[23] Wigner, P., Grębowski, R., Bijak, M., et al. (2021) The Molecular Aspect of Nephrolithiasis Development. Cells, 10, Article 1926. [Google Scholar] [CrossRef] [PubMed]
[24] Donate-Correa, J., Martín-Carro, B., Cannata-Andía, J.B., et al. (2023) Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease. Antioxidants, 12, Article 239. [Google Scholar] [CrossRef] [PubMed]
[25] Mendez-Barbero, N., Oller, J., Sanz, A.B., et al. (2023) Mito-chondrial Dysfunction in the Cardio-Renal Axis. International Journal of Molecular Sciences, 24, Article 8209. [Google Scholar] [CrossRef] [PubMed]
[26] Evan, A.P., Worcester, E.M., Coe, F.L., et al. (2015) Mechanisms of Human Kidney Stone Formation. Urolithiasis, 43, 19-32. [Google Scholar] [CrossRef] [PubMed]
[27] Saenz-Medina, J., Muñoz, M., Rodriguez, C., et al. (2022) Endothelial Dysfunction: An Intermediate Clinical Feature between Urolithiasis and Cardiovascular Diseases. In-ternational Journal of Molecular Sciences, 23, Article 912. [Google Scholar] [CrossRef] [PubMed]
[28] Alokda, A. and Van Raamsdonk, J.M. (2023) Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity. Antioxidants, 12, Article 944. [Google Scholar] [CrossRef] [PubMed]
[29] Zhang, Q., Liu, J., Duan, H., et al. (2021) Activation of Nrf2/HO-1 Signaling: An Important Molecular Mechanism of Herbal Medicine in the Treatment of Atherosclerosis via the Protection of Vascular Endothelial Cells from Oxidative Stress. Journal of Advanced Research, 34, 43-63. [Google Scholar] [CrossRef] [PubMed]
[30] Jakobs, P., Serbulea, V., Leitinger, N., et al. (2017) Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart. Antioxidants & Redox Signaling, 26, 630-644. [Google Scholar] [CrossRef] [PubMed]
[31] Lukosz, M., Jakob, S., Büchner, N., et al. (2010) Nuclear Redox Signaling. Antioxidants & Redox Signaling, 12, 713-742. [Google Scholar] [CrossRef] [PubMed]
[32] Oberacker, T., Kraft, L., Schanz, M. and Latus, J. (2023) The Importance of Thioredoxin-1 in Health and Disease. Antioxidants, 12, Article 1078. [Google Scholar] [CrossRef] [PubMed]
[33] Wang, J., Bai, Y., Yin, S., et al. (2021) Circadian Clock Gene BMAL1 Reduces Urinary Calcium Oxalate Stones Formation by Regulating NRF2/HO-1 Pathway. Life Sciences, 265, Article ID: 118853. [Google Scholar] [CrossRef] [PubMed]
[34] Ahmatjan, B., Ruotian, L., Rahman, A., et al. (2023) Klotho Inhibits the Formation of Calcium Oxalate Stones by Regulating the Keap1-Nrf2-ARE Signaling Pathway. Inter-national Urology and Nephrology, 55, 263-276. [Google Scholar] [CrossRef] [PubMed]
[35] Zhang, X., Liang, F., Li, T., et al. (2023) Metformin Ame-liorates Calcium Oxalate Crystallization and Stone Formation by Activating the Nrf2/HO-1 Signaling Pathway: Two Birds with One Stone. Archives of Biochemistry and Biophysics, 739, Article ID: 109568. [Google Scholar] [CrossRef] [PubMed]