特应性皮炎发病机制及危险因素研究进展
Research Progress on Pathogenesis and Risk Factors of Atopic Dermatitis
DOI: 10.12677/ACM.2024.142581, PDF,    科研立项经费支持
作者: 洪永镇, 梁俊琴*:新疆医科大学研究生学院,新疆 乌鲁木齐;新疆维吾尔自治区人民医院皮肤性病科,新疆皮肤病临床医学研究中心,新疆皮肤病研究重点实验室(XJYS1707),新疆 乌鲁木齐
关键词: 特应性皮炎发病机制危险因素Atopic Dermatitis Pathogenesis Risk Factor
摘要: 特应性皮炎是一种慢性炎症性皮肤病,其发病机制与遗传因素、环境因素、免疫因素及皮肤屏障功能缺陷等有关。随着社会不断前进和发展,人们生活环境、饮食习惯不断变化,AD的发病率在全球范围内呈逐年上升趋势,严重影响患者的生活质量和生命活动,并给社会造成很大的医疗负担。本文重点探讨特应性皮炎患者发病机制及相关危险因素。从而更好的预测其在疾病风险中的价值,继而科学地指导易感人群的生活饮食行为、减少过敏反应的发生,为提升患者及其家庭的生活质量提供帮助。
Abstract: Atopic dermatitis is a chronic inflammatory skin disease. Its pathogenesis is related to genetic factors, environmental factors, immune factors and skin barrier dysfunction. With the continuous progress and development of society, people’s living environment and eating habits are constantly changing, and the incidence of AD is on the rise year by year worldwide, seriously affecting the quality of life and life activities of patients, and causing great medical burden to society. This article focuses on the pathogenesis and related risk factors of atopic dermatitis, in order to better predict its value in disease risk, and then scientifically guide the life and diet behavior of susceptible people, reduce the occurrence of allergic reactions, and provide help to improve the quality of life of patients and their families.
文章引用:洪永镇, 梁俊琴. 特应性皮炎发病机制及危险因素研究进展[J]. 临床医学进展, 2024, 14(2): 4196-4200. https://doi.org/10.12677/ACM.2024.142581

参考文献

[1] Mao, D., Li, J., Liu, S., et al. (2023) Prevalence and Risk Factors of Atopic Dermatitis in Chinese Adults: A Nationwide Population-Based Cross-Sectional Study. Chinese Medical Journal, 136, 604-606. [Google Scholar] [CrossRef
[2] Hu, Y., Liu, S., Liu, P., et al. (2020) Clinical Relevance of Eosinophils, Basophils, Serum Total IgE Level, Allergen-Specific IgE, and Clinical Features in Atopic Dermatitis. Journal of Clinical Laboratory Analysis, 34, e23214. [Google Scholar] [CrossRef] [PubMed]
[3] Liu, P., Zhao, Y., Mu, Z.L., et al. (2016) Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis. Chinese Medical Journal, 129, 757-762. [Google Scholar] [CrossRef] [PubMed]
[4] Kong, H.H., Oh, J., Deming, C., et al. (2012) Temporal Shifts in The Skin Microbiome Associated with Disease Flares and Treatment in Children with Atopic Dermatitis. Genome Research, 22, 850-859. [Google Scholar] [CrossRef] [PubMed]
[5] Kanwar, A.J. (2016) Adult-Onset Atopic Dermatitis. Indian Journal of Dermatology, 61, 662-663. [Google Scholar] [CrossRef] [PubMed]
[6] Silvestre Salvador, J.F., Romero-Pérez, D. and Encabo-Durán, B. (2017) Atopic Dermatitis in Adults: A Diagnostic Challenge. Journal of Investigational Allergology & Clinical Immu-nology, 27, 78-88. [Google Scholar] [CrossRef] [PubMed]
[7] Wang, D., Wu, X.G., Yan, S., et al. (2022) Risk Factors for Food Sensi-tization in Children with Atopic Dermatitis: A Single-Center Cross-Sectional Study. Chinese Journal of Contemporary Pediatrics, 24, 887-893.
[8] 刘钊梁. 特应性皮炎与2型炎症反应[J]. 中华皮肤科杂志, 2021, 54(1): 84-88. [Google Scholar] [CrossRef
[9] Irvine, A.D., McLean, W.H. and Leung, D.Y. (2011) Filaggrin Mu-tations Associated with Skin and Allergic Diseases. The New England Journal of Medicine, 365, 1315-1327. [Google Scholar] [CrossRef
[10] Perälä, M., Kaustio, M., Salava, A., et al. (2023) Relevance of Coding Variation in FLG and DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-to-Severe Atopic Der-matitis. JID Innovations, 3, Article ID: 100203. [Google Scholar] [CrossRef] [PubMed]
[11] Van Den Bogaard, E.H., Elias, P.M., Goleva, E., et al. (2023) Targeting Skin Barrier Function in Atopic Dermatitis. The Journal of Allergy and Clinical Immunology: In Practice, 11, 1335-1346. [Google Scholar] [CrossRef] [PubMed]
[12] Dubin, C., Del Duca, E. and Guttman-Yassky, E. (2021) The IL-4, IL-13 and IL-31 Pathways in Atopic Dermatitis. Expert Review of Clinical Immunology, 17, 835-852. [Google Scholar] [CrossRef
[13] Facheris, P., Jeffery, J., Del Duca, E. and Guttman-Yassky, E. (2023) The Translational Revolution in Atopic Dermatitis: The Paradigm Shift From Pathogenesis to Treatment. Cellular & Molecular Immunology, 20, 448-474. [Google Scholar] [CrossRef] [PubMed]
[14] Haddad, E., Cyr, S., Arima, K., et al. (2022) Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis. Dermatology and Therapy, 12, 1501-1533. [Google Scholar] [CrossRef] [PubMed]
[15] Licona-Limón, P., Henao-Mejia, J., Temann, A., et al. (2013) Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection. Immunity, 39, 744-757. [Google Scholar] [CrossRef] [PubMed]
[16] Progneaux, A., Evrard, C., De Glas, V., et al. (2023) Keratinocytes Activated by IL-4/IL-13 Express IL-2Rγ with Consequences on Epidermal Barrier Function. Experimental Dermatology, 32, 660-670. [Google Scholar] [CrossRef] [PubMed]
[17] Nedoszytko, B., Reszka, E., Gutowska-Owsiak, D., et al. (2020) Genetic and Epigenetic Aspects of Atopic Dermatitis. International Journal of Molecular Sciences, 21, Article 6484. [Google Scholar] [CrossRef] [PubMed]
[18] Wang, X., Shi, X.D., Li, L.F., et al. (2017) Prevalence and Clinical Features of Adult Atopic Dermatitis in Tertiary Hospitals of China. Medicine, 96, e6317. [Google Scholar] [CrossRef
[19] Sargen, M.R., Hoffstad, O. and Margolis, D.J. (2014) Warm, Humid, and High Sun Exposure Climates Are Associated with Poorly Controlled Eczema: PEER (Pediatric Eczema Elective Registry) Cohort, 2004-2012. Journal of Investigative Dermatology, 134, 51-57. [Google Scholar] [CrossRef] [PubMed]
[20] Halling-Overgaard, A.S., Kezic, S., Jakasa, I., et al. (2017) Skin Ab-sorption through Atopic Dermatitis Skin: A Systematic Review. British Journal of Dermatology, 177, 84-106. [Google Scholar] [CrossRef] [PubMed]
[21] Tham, E.H., Rajakulendran, M., Lee, B.W., et al. (2020) Epicutaneous Sensitization to Food Allergens in Atopic Dermatitis: What Do We Know? Pediatric Allergy and Immunology, 31, 7-18. [Google Scholar] [CrossRef] [PubMed]
[22] Fukuie, T., Yasuoka, R., Fujiyama, T., et al. (2019) Palmar Hyperlinearity in Early Childhood Atopic Dermatitis Is Associated with Filaggrin Mutation and Sensitization to Egg. Pediatric Dermatology, 36, 213-218. [Google Scholar] [CrossRef] [PubMed]
[23] Ng, J.C. and Yew, Y.W. (2022) Effect of Vitamin D Serum Levels and Supplementation on Atopic Dermatitis: A Systematic Review and Meta-Analysis. American Journal of Clinical Der-matology, 23, 267-275. [Google Scholar] [CrossRef] [PubMed]
[24] Son, J.H., Chung, B.Y., Kim, H.O., et al. (2017) Clinical Fea-tures of Atopic Dermatitis in Adults Are Different According to Onset. Journal of Korean Medical Science, 32, 1360-1366. [Google Scholar] [CrossRef] [PubMed]
[25] Luo, M., Su, H.C., Lin, J.E., et al. (2023) A Retro-spective Analysis of Risk Factors for Atopic Dermatitis Severity. Dermatitis, 35, S81-S90. [Google Scholar] [CrossRef] [PubMed]
[26] Maurelli, M., Chiricozzi, A., Peris, K., et al. (2023) Atopic Dermatitis in the Elderly Population. Acta Dermato-Venereologica, 103, adv13363. [Google Scholar] [CrossRef] [PubMed]