颅内静脉窦血栓形成的治疗进展
Advancements in the Treatment of Intracranial Venous Sinus Thrombosis
DOI: 10.12677/ACM.2024.142592, PDF,   
作者: 帕孜力亚·艾克拉木, 牛伟伟, 王增亮*：新疆医科大学第一附属医院神经外科中心，新疆 乌鲁木齐
关键词: 静脉窦血栓；血管内治疗；抗凝；Venous Sinus Thrombosis； Endovascular Treatment； Anticoagulation
摘要: 颅内静脉窦血栓形成是一种独特的脑血管疾病，具有高度变化和不可预测的临床过程，尽管进行了治疗，仍有部分患者发生死亡或遗留慢性头痛不能重返工作岗位。抗凝治疗被认为是主要的手段及目标，以此改善局部灌注，避免更严重的神经功能缺损。随着技术的发展，越来越多神经介入装置也随之优化，血管内治疗也被多数临床医师考虑来治疗抗凝无效或重症患者，然而当前对于颅内静脉窦血栓干预时机的选择，手术方式以及预后评价量表等暂未统一，本文就当前的治疗进展作一综述。
Abstract: Intracranial venous sinus thrombosis is a unique cerebrovascular disease characterized by a highly variable and unpredictable clinical course. Despite treatment efforts, some patients still experience mortality or persistent chronic headaches that hinder their return to work. Anticoagulation therapy is considered a primary and targeted approach to improve local perfusion and prevent more severe neurological deficits. With technological advancements, an increasing number of neurointerventional devices have been optimized, and endovascular treatments are increasingly considered by clinicians to address cases of anticoagulation ineffectiveness or severe conditions. However, there is currently no unified consensus on the timing of intervention, surgical methods, and prognostic assessment scales for intracranial venous sinus thrombosis. This article provides a comprehensive review of the current advancements in treatment.
文章引用：帕孜力亚·艾克拉木, 牛伟伟, 王增亮. 颅内静脉窦血栓形成的治疗进展[J]. 临床医学进展, 2024, 14(2): 4275-4280. https://doi.org/10.12677/ACM.2024.142592

参考文献

[1] Bertani, R., Rodrigues, R.B., Koester, S.W., et al. (2020) Complicated Cerebral Venous Thrombosis during the First Trimester of Pregnancy. Cureus, 12, 8-14. [Google Scholar] [CrossRef] [PubMed]
[2] Duman, T., Uluduz, D., Midi, I., et al. (2017) A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: the VENOST Study. Journal of Stroke and Cerebrovascular Diseases, 26, 1848-1857.
[3] Mahmoud, A., Ekin, U., Kania, B., Shrouf, A. and Maroules, M. (2022) Cerebral Venous Sinus Thrombosis in Pregnancy Presenting with Hemiplegia: A Case Report. Radiology Case Reports, 17, 3713-3717. [Google Scholar] [CrossRef] [PubMed]
[4] Silvis, S.M., de Sousa, D.A., Ferro, J.M. and Coutinho, J.M (2017) Cerebral Venous Thrombosis. Nature Reviews Neurology, 13, 555-565. [Google Scholar] [CrossRef] [PubMed]
[5] 易婷玉, 吴燕敏, 林定来, 等. AngioJet流变溶栓抽栓术治疗颅内静脉窦血栓形成三例效果分析并文献复习[J]. 中国脑血管病杂志, 2021, 18(5): 311-319.
[6] Ferro, J.M. and de Sousa, D.A. (2019) Cerebral Venous Thrombosis: An Update. Current Neurology and Neuroscience Reports, 19, Article No. 74. [Google Scholar] [CrossRef] [PubMed]
[7] Lindgren, E., Jood, K. and Tatlisumak, T. (2018) Vocational Outcome in Cerebral Venous Thrombosis: Long-Term Follow-Up Study. Acta Neurologica Scandinavica, 137, 299-307. [Google Scholar] [CrossRef] [PubMed]
[8] 王登宇, 王君, 张荣举, 等. 颅内静脉系统窦汇解剖形态学分析及其对静脉系统相关疾病的临床意义[J]. 中国脑血管病杂志, 2019, 16(12): 642-646.
[9] Pai, N., Ghosh, K. and Shetty, S. (2013) Hereditary Thrombophilia in Cerebral Venous Thrombosis: A Study from India. Blood Coag-ulation & Fibrinolysis, 24, 540-543. [Google Scholar] [CrossRef] 
[10] Alet, M., Ciardi, C., Alemán, A., et al. (2020) Cerebral Venous Thrombosis in Argentina: Clinical Presentation, Predisposing Factors, Out-comes and Literature Review. Journal of Stroke and Cerebrovascular Diseases, 29, Article ID: 105145. [Google Scholar] [CrossRef] [PubMed]
[11] De Bruijn, S.F., Stam, J. and Kappelle, L.J. (1996) Thunderclap Headache as First Symptom of Cerebral Venous Sinus Thrombosis. The Lancet, 348, 1623-1625. [Google Scholar] [CrossRef] 
[12] 范冲竹, 李海南, 向璇, 等. 易误诊为脑肿瘤的颅内静脉窦血栓形成[J]. 中国现代神经疾病杂志, 2021, 21(12): 1089-1094.
[13] 宋金玲, 时雅辉, 梁可可, 等. 脑静脉系统血栓形成123例临床表现和影像学特点[J]. 中国实用神经疾病杂志, 2017, 20(3): 10-13.
[14] 何静, 马艳, 任勇, 等. 颅内静脉窦血栓形成的临床特征分析[J]. 宁夏医学杂志, 2017, 39(5): 402-405.
[15] Kim, D.J., Honig, A., Alimohammadi, A., Sepehry, A.A., Zhou, L.W. and Field, T.S. (2023) Recanalization and Outcomes after Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis. Research and Practice in Thrombosis and Haemostasis, 7, Article ID: 100143. [Google Scholar] [CrossRef] [PubMed]
[16] Nepal, G., et al. (2022) Safety and Efficacy of Direct Oral Anticoagulants in Cerebral Venous Thrombosis: A Meta-Analysis. Acta Neurologica Scandinavica, 145, 10-23. [Google Scholar] [CrossRef] [PubMed]
[17] 徐丙发, 林绪芳, 孔薇, 等. 我院华法林临床应用分析[J]. 中国药房, 2016, 27(3): 318-320.
[18] Geisbüsch, C., Richter, D., Herweh, C., et al. (2014) Novel Factor Xa Inhibitor for the Treatment of Cerebral Venous and Sinus Thrombosis: First Experience in 7 Patients. Stroke, 45, 2469-2471. [Google Scholar] [CrossRef] 
[19] Yaghi S, Saldanha, I.J., Misquith, C., et al. (2022) Direct Oral Anticoagulants versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Me-ta-Analysis. Stroke, 53, 3014-3024. [Google Scholar] [CrossRef] 
[20] Kowoll, C.M., Lockau, H., Dorn, F. and Dohmen, C. (2017) Aggressive Treatment of Cerebral Venous Sinus Thrombosis (CVT) with Stent Retrievers and Local Throm-bolysis: Why We Need a Registry. Fortschritte der Neurologie Psychiatrie, 85, 605-610. [Google Scholar] [CrossRef] [PubMed]
[21] Wang, J., Ji, X.M., Ling, F. and He, X. (2014) Comparison of Anti-coagulation and Thrombolysis Treatments in a Rat Model of Superior Sagittal Sinus Thrombosis. International Journal of Neuroscience, 124, 532-541. [Google Scholar] [CrossRef] [PubMed]
[22] 何健. 应用Solitaire AB支架机械取栓治疗颅内静脉窦血栓形成的临床研究[D]: [硕士学位论文]. 广州: 南方医科大学, 2018.
[23] 张维雄. POEMS综合征合并颅内静脉窦血栓形成一例[J]. 中华神经科杂志, 2017, 50(9): 691-693.
[24] Yang, J., Wang, H., Chen, Y., Qiu, M., Zhang, B. and Chen, Z. (2021) Balloon-Assisted Thrombectomy and Intrasinus Urokinase Thrombolysis for Severe Cerebral Ve-nous Sinus Thrombosis. Frontiers in Neurology, 12, Article ID: 735540. [Google Scholar] [CrossRef] [PubMed]
[25] Ding, R., Li, H.Y., Liu, Y.Q., et al. (2022) Activating CGAS-STING Axis Contributes to Neuroinflammation in CVST Mouse Model and Induces Inflammasome Activation and Microglia Pyroptosis. Journal of Neuroinflammation, 19, Article No. 137. [Google Scholar] [CrossRef] [PubMed]

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