血清炎性标志物对溃疡性结肠炎活动度的预测价值
Predictive Value of Serum Inflammatory Markers on Activity of Ulcerative Colitis
DOI: 10.12677/ACM.2024.142618, PDF,   
作者: 马小梅：新疆医科大学第一临床医学院，新疆 乌鲁木齐；李雅丽*：新疆医科大学第一附属医院综合内四科，新疆 乌鲁木齐
关键词: 溃疡性结肠炎；炎症因子；细胞变化；活动度；炎性反应标志物；Ulcerative Colitis； Inflammatory Factors； Cellular Changes； Activity； Inflammatory Response Marker
摘要: 近年来，溃疡性结肠炎(ulcerative colitis, UC)在我国的发病率呈不断上升趋势，其以反复发作的腹痛、腹泻和黏液脓血便为主要临床表现，病变主要局限于结直肠黏膜层及黏膜下层。溃疡性结肠炎的致病因素较为复杂，发病机制尚未完全明确，炎症因子和细胞变化在其发展过程中起至关重要的作用。目前电子结肠镜检查是评估溃疡性结肠炎疾病活动度的金标准，该检查属于有创操作，且易二次损伤肠道黏膜。因此，临床上通过检测外周血中相关的炎性反应标志物用以评估溃疡性结肠炎疾病活动度，可方便、快捷地监测溃疡性结肠炎疾病的活动度。
Abstract: In recent years, the incidence of ulcerative colitis in China has been on the rise. The main clinical manifestations of ulcerative colitis are recurrent abdominal pain, diarrhea and mucous, pus and blood, and the lesions are mainly confined to the colorectal mucosa and submucosa. The pathogenic factors of ulcerative colitis are complex and the pathogenesis has not been fully defined. Inflamma-tory factors and cellular changes play a crucial role in its development. At present, electronic colon-oscopy is the gold standard for evaluating the disease activity of ulcerative colitis, which is an inva-sive procedure and prone to secondary damage of intestinal mucosa. Therefore, the activity of ul-cerative colitis disease can be easily and quickly monitored by detecting relevant inflammatory re-sponse markers in peripheral blood.
文章引用：马小梅, 李雅丽. 血清炎性标志物对溃疡性结肠炎活动度的预测价值[J]. 临床医学进展, 2024, 14(2): 4453-4460. https://doi.org/10.12677/ACM.2024.142618

参考文献

[1] Ye, Y., Pang, Z., Chen, W., Ju, S. and Zhou, C. (2015) The Epidemiology and Risk Factors of Inflammatory Bowel Disease. International Journal of Clinical and Experimental Medicine, 8, 22529-22542.
[2] Segal, J.P., LeBlanc, J.F. and Hart, A.L. (2021) Ulcerative Colitis: An Update. Clinical Medicine (London), 21, 135- 139. [Google Scholar] [CrossRef] [PubMed]
[3] 范宜佳, 刘珏, 余炜杰. 溃疡性结肠炎患儿血清炎症细胞因子水平变化及临床价值分析[J]. 中国妇幼保健, 2022, 37(14): 2586-2589.
[4] Kobayashi, T., Siegmund, B., Le Berre, C., et al. (2020) Ulcerative Colitis. Nature Reviews Disease Primers, 6, Article No. 74. [Google Scholar] [CrossRef] [PubMed]
[5] Popov, J., Caputi, V., Nandeesha, N., Rodriguez, D.A. and Pai, N. (2021) Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbio-ta-Based Therapies. International Journal of Molecular Sciences, 22, Article No. 11365. [Google Scholar] [CrossRef] [PubMed]
[6] 李晓彤, 霍丽娟. 系统免疫炎症指数与溃疡性结肠炎疾病活动度的相关性分析[J]. 国际消化病杂志, 2022, 42(5): 289-293.
[7] Sonoyama, H., Kawashima, K., Ishihara, S., et al. (2019) Capabilities of Fecal Calprotectin and Blood Biomarkers as Surrogate Endoscopic Markers According to Ulcera-tive Colitis Disease Type. Journal of Clinical Biochemistry and Nutrition, 64, 265-270. [Google Scholar] [CrossRef] [PubMed]
[8] Xu, M., Cen, M., Chen, X., Chen, H., Liu, X. and Cao, Q. (2019) Correla-tion between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease. BioMed Re-search International, 2019, Article ID: 6517549. [Google Scholar] [CrossRef] [PubMed]
[9] Hu, B., Yang, X.R., Xu, Y., et al. (2014) Systemic Immune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular Carcinoma. Clinical Cancer Research, 20, 6212-6222. [Google Scholar] [CrossRef] 
[10] Drury, B., Hardisty, G., Gray, R.D. and Ho, G.T. (2021) Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation. Cellu-lar and Molecular Gastroenterology and Hepatology, 12, 321-333. [Google Scholar] [CrossRef] [PubMed]
[11] Wesche, D.E., Lomas-Neira, J.L., Perl, M., Chung, C.S. and Ayala, A. (2005) Leukocyte Apoptosis and Its Significance in Sepsis and Shock. Journal of Leukocyte Biology, 78, 325-337. [Google Scholar] [CrossRef] [PubMed]
[12] Hassan, G.S., Salti, S. and Mourad, W. (2022) Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis. Cells, 11, Article No. 1747. [Google Scholar] [CrossRef] [PubMed]
[13] Kundrapu, S., Srivastava, S., Good, C.E., Lazarus, H.M., Maitta, R.W. and Jacobs, M.R. (2020) Bacterial Contamination and Septic Transfusion Reaction Rates Associated with Platelet Com-ponents Before and after Introduction of Primary Culture: Experience at a US Academic Medical Center 1991 through 2017. Transfusion, 60, 974-985. [Google Scholar] [CrossRef] [PubMed]
[14] Furukawa, S., Yagi, S., Shiraishi, K., et al. (2020) Association between Platelet Count and Mucosal Healing in Japanese Patients with Ulcerative Colitis: A Cross-Sectional Study. BMC Gas-troenterology, 20, Article No. 384. [Google Scholar] [CrossRef] [PubMed]
[15] Voudoukis, E., Karmiris, K. and Koutroubakis, I.E. (2014) Mul-tipotent Role of Platelets in Inflammatory Bowel Diseases: A Clinical Approach. World Journal of Gastroenterology, 20, 3180-3190. [Google Scholar] [CrossRef] [PubMed]
[16] 郑淑贤, 孟品, 闫静, 等. 全身免疫炎症指数评估溃疡性结肠炎严重程度的价值[J]. 青岛大学学报(医学版), 2023, 59(2): 183-188.
[17] Chen, Y.H., Wang, L., Feng, S.Y., Cai, W.M., Chen, X.F. and Huang, Z.M. (2020) The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease. Gastroenterology Research and Practice, 2020, Article ID: 3467419. [Google Scholar] [CrossRef] [PubMed]
[18] Zhang, M.H., Wang, H., Wang, H.G., Wen, X. and Yang, X.Z. (2021) Effective Immune-Inflammation Index for Ulcerative Colitis and Activity Assessments. World Journal of Clinical Cases, 9, 334-343. [Google Scholar] [CrossRef] [PubMed]
[19] 杨欣怡, 阳惠湘. 炎症性肠病合并贫血的诊治进展[J]. 国际消化病杂志, 2022, 42(3): 150-154.
[20] Stein, J. and Dignass, A.U. (2013) Management of Iron Deficiency Anemia in In-flammatory Bowel Disease—A Practical Approach. Annals of Gastroenterology, 26, 104-113.
[21] Schmidt, C., Bokemeyer, B., Lügering, A., et al. (2022) Clinical Predictors for a Complicated Course of Disease in an Inception Co-hort of Patients with Ulcerative Colitis: Results from the Prospective, Observational EPICOL Study. International Jour-nal of Colorectal Disease, 37, 485-493. [Google Scholar] [CrossRef] [PubMed]
[22] 李慧敏, 王莲子, 王中新, 等. 血清PAR水平与溃疡性结肠炎活动期患者严重程度的相关性分析[J]. 中国处方药, 2023, 21(8): 165-168.
[23] Ando, K., Fujiya, M., Nomura, Y., et al. (2018) The Incidence and Risk Factors of Venous Thrombo-embolism in Japanese Inpatients with Inflammatory Bowel Disease: A Retrospective Cohort Study. Intestinal Research, 16, 416-425. [Google Scholar] [CrossRef] [PubMed]
[24] Chiarantini, E., Valanzano, R., Liotta, A.A., et al. (1996) Hemostatic Abnormalities in Inflammatory Bowel Disease. Thrombosis Research, 82, 137-146. [Google Scholar] [CrossRef] [PubMed]
[25] 程海花, 边佳. D-二聚体、部分凝血活酶时间及纤维蛋白原在老年溃疡性结肠炎患者的检测意义[J]. 血栓与止血学, 2022, 28(2): 258-259.
[26] 赵旭. D-二聚体、部分凝血活酶时间与溃疡性结肠炎患者疾病严重程度的关系[J]. 中国肛肠病杂志, 2023, 43(4): 45-47.
[27] Header, D.A., Aboelwafa, R.A., Elkeleny, M.R., Bedewy, E.S. and Ellakany, A.I. (2022) C-Reactive Protein/Albumin Ratio (CAR) as a Marker for Detecting Acute Severe Ulcerative Colitis in Egyptian Patients. Revista de Gastroenterología de México (Engl Ed), 87, 447-454. [Google Scholar] [CrossRef] [PubMed]
[28] Dolinger, M.T., Spencer, E.A., Lai, J., Dunkin, D. and Dubinsky, M.C. (2021) Dual Biologic and Small Molecule Therapy for the Treatment of Refractory Pe-diatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 27, 1210-1214. [Google Scholar] [CrossRef] [PubMed]
[29] 申婷婷, 王文豪, 陈宁, 等. 溃疡性结肠炎患者红细胞参数、ESR、CRP及凝血功能分析[J]. 潍坊医学院学报, 2021, 43(3): 227-229+242.
[30] 祝君, 赵黎明, 徐建光. 溃疡性结肠炎患者降钙素原、红细胞沉降率、C-反应蛋白水平分析[J]. 中国卫生检验杂志, 2022, 32(3): 350-353.
[31] 齐伟翠, 黄声旗. 血清降钙素原检测对慢性肾衰竭伴细菌感染的诊断价值分析[J]. 中国卫生检验杂志, 2020, 30(15): 1886-1887+1891.
[32] 肖迅, 胡晓, 刘培曦, 等. 血清降钙素原和超敏C-反应蛋白在评价炎症性肠病活动度中的临床价值研究[J]. 世界最新医学信息文摘, 2018, 18(26): 26-27+29.
[33] Thia, K.T., Chan, E.S., Ling, K.L., Ng, W.Y., Jacob, E. and Ooi, C.J. (2008) Role of Procalcitonin in Infectious Gastroenteritis and Inflammatory Bowel Disease. Digestive Diseases and Sciences, 53, 2960-2968. [Google Scholar] [CrossRef] [PubMed]
[34] 常钰玲, 桑虎, 李伟. 溃疡性结肠炎患者血清C反应蛋白、降钙素原及白细胞介素-6水平的表达情况及临床意义分析[J]. 大医生, 2023, 8, 13): 110-112.
[35] 梁丽娟, 赖卫国, 朱春平, 等. 溃疡性结肠炎中肠道菌群相关治疗的研究进展[J]. 南昌大学学报(医学版), 2023, 63(4): 94-99.
[36] Pratt, M., Forbes, J.D., Knox, N.C., Van Domselaar, G. and Bernstein, C.N. (2022) Colorectal Cancer Screening in Inflammatory Bowel Diseases-Can Characterization of GI Microbiome Signatures Enhance Neoplasia De-tection? Gastroenterology, 162, 1409-1423. [Google Scholar] [CrossRef] [PubMed]
[37] 邹艳芳. 奥硝唑联合美沙拉嗪对溃疡性结肠炎患者肠道黏膜屏障功能及复发率的影响[J]. 医学理论与实践, 2021, 34(6): 960-961.
[38] Feng, W., Liu, Y., Zhu, L., Xu, L. and Shen, H. (2022) Evaluation of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Potential Markers for Ulcerative Colitis: A Retrospective Study. BMC Gastroenter-ology, 22, Article No. 485. [Google Scholar] [CrossRef] [PubMed]
[39] Che, L., Li, Y., Song, R., et al. (2019) Anti-Inflammatory and Anti-Apoptosis Activity of Taraxasterol in Ulcerative Colitis in Vitro and in Vivo. Experimental and Therapeutic Medicine, 18, 1745-1751. [Google Scholar] [CrossRef] [PubMed]
[40] 王松, 刘流, 张开光. 单核细胞和单核细胞/淋巴细胞比值对判断溃疡性结肠炎严重程度的临床价值[J]. 中华全科医学, 2020, 18(6): 895-898+1065.
[41] Mańkowska-Wierzbicka, D., Swora-Cwynar, E., Poniedziałek, B., Adamski, Z., Dobrowolska, A. and Karczewski, J. (2015) Usefulness of Se-lected Laboratory Markers in Ulcerative Colitis. European Cytokine Network, 26, 26-37. [Google Scholar] [CrossRef] [PubMed]
[42] Edelblum, K.L., Yan, F., Yamaoka, T. and Polk, D.B. (2006) Regula-tion of Apoptosis during Homeostasis and Disease in the Intestinal Epithelium. Inflammatory Bowel Diseases, 12, 413-424. [Google Scholar] [CrossRef] 
[43] Shi, H., Feng, Y., Jiang, J., Zhao, J., Li, X. and Liu, X. (2019) Correlations between the Serum Bilirubin Level and Ulcerative Colitis: A Case-Control Study. European Journal of Gastroenterology & Hepatology, 31, 992-997. [Google Scholar] [CrossRef] 
[44] Belvis Jiménez, M., Hergueta-Delgado, P., Gómez Rodríguez, B., et al. (2021) Comparison of the Mayo Endoscopy Score and the Ulcerative Colitis Endoscopy Index of Severity and the Ulcerative Colitis Colonoscopy Index of Severity. Endoscopy International Open, 9, E130-E136. [Google Scholar] [CrossRef] [PubMed]
[45] 闫静, 武军, 张晓静, 等. 血清学比值指标评估溃疡性结肠炎内镜下严重程度的临床价值[J]. 青岛大学学报(医学版), 2023, 59(5): 725-729.

为你推荐