术前外周血SII、NLR、PLR、FAR、MLR及CA125在卵巢透明细胞癌诊断中的临床价值分析

Analysis of the Preoperative Clinical Value of Peripheral Blood SII, NLR, PLR, FAR, MLR, and CA125 in the Diagnosis of Ovarian Clear Cell Carcinoma

摘要: 目的：探讨术前外周血系统性免疫炎症指数(SII)、中性粒细胞–淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、纤维蛋白原–白蛋白比值(FAR)、单核细胞–淋巴细胞比值(MLR)及血清糖类抗原125(CA125)在卵巢良性肿瘤及卵巢透明细胞癌(OCCC)中的差异，分析其诊断价值。方法：选取青岛大学附属医院2014年1月~2023年9月收治的114例卵巢透明细胞癌(卵巢透明细胞癌组)和119例卵巢良性肿瘤(卵巢良性肿瘤组)患者的临床资料进行回顾性分析。检测术前外周血中SII、NLR、PLR、FAR、MLR及CA125水平，对每组病例所对应的SII、NLR、PLR、FAR、MLR及CA125进行对比分析，运用受试者工作特征(ROC)曲线分析SII、NLR、PLR、FAR、MLR及CA125在卵巢透明细胞癌中诊断价值。结果：OCCC组术前外周血SII、NLR、PLR、MLR及CA125水平高于卵巢良性肿瘤组，FAR水平低于卵巢良性肿瘤组，差异有统计学意义。SII、NLR、PLR、FAR、MLR及CA125的ROC曲线下面积(AUC)分别为0.729、0.720、0.708、0.869、0.719、0.696。结论：术前外周血SII、NLR、PLR、FAR、MLR可作为辅助临床评估与诊断OCCC的指标。

Abstract: Objective: To investigate the diagnostic value of preoperative systemic immune inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), fibrinogen-al- bumin ratio (FAR), monocyte-lymphocyte ratio (MLR) and serum glucose antigen 125 (CA125) in benign ovarian tumors and ovarian clear cell carcinoma (OCCC). Methods: The clinical data of 114 ovarian clear cell carcinoma (ovarian clear cell carcinoma group) and 119 ovarian benign tumors (ovarian benign tumor group) admitted from January 2014 to September 2023 were selected for retrospec-tive analysis. SII, NLR, PLR, FAR, MLR and CA125 in peripheral blood, SII, NLR, PLR, FAR, MLR and CA125 in each group were analyzed to analyze the value of SII, NLR, PLR, FAR, MLR and CA125 in ovarian clear cell carcinoma. Results: The SII, NLR, PLR, MLR and CA125 levels in OCCC group were higher than the benign ovarian tumor group, and the FAR level was lower than the benign ovarian tumor group. The area under the ROC curve (AUC) for SII, NLR, PLR, FAR, MLR and CA125 were 0.729, 0.720, 0.708, 0.869, 0.719 and 0.696, respectively. Conclusion SII, NLR, PLR, FAR and MLR in preoperative peripheral blood can be used for auxiliary clinical evaluation and diagnosis of OCCC.