环泊酚在老年患者麻醉中应用的研究进展
Research Progress on the Application of Ciprofol in Anesthesia in Elderly Patients
DOI: 10.12677/ACM.2024.142646, PDF,   
作者: 吴延明, 董 涛, 赖 博：内蒙古民族大学第二临床医学院(内蒙古林业总医院)，内蒙古 牙克石
关键词: 环泊酚；老年患者；麻醉；Ciprofol； Elderly Patient； Anesthesia
摘要: 环泊酚是一种新型非巴比妥类静脉麻醉药，其化学结构与丙泊酚类似，环泊酚具有起效快、恢复快、注射痛少等优点，老年患者由于自身独特的病理生理特性，应用环泊酚可能会有较好的治疗效果。目前，环泊酚在老年患者的应用多处于初级阶段，其确切疗效仍需要进一步研究，本文就近年环泊酚在老年患者中的应用进行综述，并对其在未来的应用中进行展望。
Abstract: Ciprofol is a new type of non-barbiturate intravenous anesthetic, whose chemical structure is simi-lar to that of propofol. Ciprofol has the advantages of quick onset, quick recovery and less injection pain, etc. Due to its unique pathophysiological characteristics, the application of Ciprofol in elderly patients may have better therapeutic effects. At present, the application of Ciprofol in elderly pa-tients is mostly in the initial stage, and its exact efficacy still needs to be further studied. In the present review, we discuss the application of Ciprofol in elderly patients in recent years, and its fu-ture application is prospected.
文章引用：吴延明, 董涛, 赖博. 环泊酚在老年患者麻醉中应用的研究进展[J]. 临床医学进展, 2024, 14(2): 4663-4667. https://doi.org/10.12677/ACM.2024.142646

参考文献

[1] 王悠笛, 陈亮, 孙盈盈, 等. 环泊酚或丙泊酚复合瑞芬太尼用于无痛纤维支气管镜检查的比较[J]. 临床麻醉学杂志, 2023, 39(10): 1050-1054.
[2] 王妮, 龚勋, 谭柏栋, 等. 右美托咪定、咪达唑仑和丙泊酚在ICU机械通气患者镇静治疗中的有效性和安全性: 基于贝叶斯的网状Meta分析[J]. 巴楚医学, 2021, 4(1): 69-80.
[3] 孙东旭, 张立民. 丙泊酚-依托咪酯单药/复合用药在无痛胃镜检查中的麻醉效果分析[J]. 巴楚医学, 2023, 6(4): 66-69.
[4] 宋尧, 覃禹翱, 夏雪, 等. 瑞马唑仑与右美托咪定在超声引导臂丛神经阻滞断指再植术中的麻醉效果比较[J]. 实用医学杂志, 2023, 39(24): 3243-3248.
[5] 王斌, 刘进. 近10年全球新型静脉麻醉药物临床研发动态[J]. 药学进展, 2017, 41(8): 569-573.
[6] Lu, M., Liu, J., Wu, X. and Zhang, Z. (2023) Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? BioMed Research International, 2023, Article ID: 7443226. [Google Scholar] [CrossRef] [PubMed]
[7] Bian, Y., Zhang, H., Ma, S., et al. (2021) Mass Balance, Pharmacoki-netics and Pharmacodynamics of Intravenous HSK3486, a Novel Anaesthetic, Administered to Healthy Subjects. British Journal of Clinical Pharmacology, 87, 93-105. [Google Scholar] [CrossRef] [PubMed]
[8] Hu, C., Ou, X., Teng, Y., et al. (2021) Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial. Advances in Therapy, 38, 5484-5500. [Google Scholar] [CrossRef] [PubMed]
[9] Yang, Y., Xia, Z., Xu, C., Zhai, C., Yu, X. and Li, S. (2022) Ciprofol Attenuates the Isoproterenol-Induced Oxidative Damage, Inflammatory Response and Cardiomyocyte Apoptosis. Frontiers in Pharmacology, 13, Article ID: 1037151. [Google Scholar] [CrossRef] [PubMed]
[10] Li, J., Wang, X., Liu, J., et al. (2022) Comparison of Ciprofol (HSK3486) versus Propofol for the Induction of Deep Sedation during Gastroscopy and Colonoscopy Procedures: A Multi-Centre, Non-Inferiority, Randomized, Controlled Phase 3 Clinical Trial. Basic & Clinical Pharmacology & Toxi-cology, 131, 138-148. [Google Scholar] [CrossRef] [PubMed]
[11] Teng, Y., Ou, M., Wang, X., et al. (2021) Efficacy and Safety of Ciprofol for the Sedation/Anesthesia in Patients Undergoing Colonoscopy: Phase IIa and IIb Multi-Center Clinical Trials. Euro-pean Journal of Pharmaceutical Sciences, 164, Article ID: 105904. [Google Scholar] [CrossRef] [PubMed]
[12] Wu, X.R., et al. (2024) Effective Doses of Ciprofol Combined with Alfentanil in Inhibiting Responses to Gastroscope Insertion, a Prospective, Single-Arm, Single-Center Study. BMC Anesthesiology, 24, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[13] Chen, L., Xie, Y., Du, X., et al. (2023) The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy. Drug Design, Development and Therapy, 17, 1733-1740. [Google Scholar] [CrossRef] 
[14] Bin, W., et al. (2022) The Revised-Risk Analysis Index as a Predictor of Major Morbidity and Mortality in Older Patients after Abdominal Surgery: A Retrospective Cohort Study. BMC Anesthesiology, 22, Article No. 301. [Google Scholar] [CrossRef] [PubMed]
[15] Ding, Y.Y., Long, Y.Q., Yang, H.T., Zhuang, K., Ji, F.H. and Peng, K. (2022) Efficacy and Safety of Ciprofol for General Anaesthesia Induction in Elderly Patients Undergoing Major Noncardiac Surgery: A Randomised Controlled Pilot Trial. European Journal of Anaesthesiology, 39, 960-963. [Google Scholar] [CrossRef] 
[16] Duan, G.C., et al. (2023) Clinical Effect of Different Doses of Ciprofol for Induction of General Anesthesia in Elderly Patients: A Randomized, Controlled Trial. Pharmacology Re-search & Perspectives, 11, e01066. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, L., Wang, K., Yang, Y., et al. (2024) Population Pharmacokinet-ic/Pharmacodynamic Modeling and Exposure-Response Analysis of Ciprofol in the Induction and Maintenance of Gen-eral Anesthesia in Patients Undergoing Elective Surgery: A Prospective Dose Optimization Study. Journal of Clinical Anesthesia, 92, Article ID: 111317. [Google Scholar] [CrossRef] [PubMed]
[18] Gan, T.J., Bertoch, T., Habib, A.S., et al. (2023) Comparison of the Efficacy of HSK3486 and Propofol for Induction of General Anesthesia in Adults: A Multicenter, Randomized, Double-Blind, Controlled, Phase 3 Noninferiority Trial. Anesthesiology. [Google Scholar] [CrossRef] 
[19] Zhu, Q., Luo, Z., Wang, X., et al. (2023) Efficacy and Safety of Ciprofol versus Propofol for the Induction of Anesthesia in Adult Patients: A Multicenter Phase 2a Clinical Trial. International Journal of Clinical Pharmacy, 45, 473-482. [Google Scholar] [CrossRef] [PubMed]
[20] Liu, Y.J., et al. (2022) Safety and Efficacy of Ciprofol vs. Propofol for Sedation in Intensive Care Unit Patients with Mechanical Ventilation: A Multi-Center, Open Label, Ran-domized, Phase 2 Trial. Chinese Medical Journal, 135, 1043-1051. [Google Scholar] [CrossRef] 
[21] Sun, X.X., et al. (2023) Efficacy and Safety of Ciprofol for Long-Term Sedation in Patients Receiving Mechanical Ventilation in ICUs: A Prospective, Single-Center, Double-Blind, Randomized Controlled Protocol. Frontiers in Pharmacology, 14, Article ID: 1235709. [Google Scholar] [CrossRef] [PubMed]
[22] Liu, G.L., Wu, G.Z., Ge, D., et al. (2023) Efficacy and Safety of Ciprofol for Agitation and Delirium in the ICU: A Multicenter, Single-Blind, 3-Arm Parallel Randomized Controlled Tri-al Study Protocol. Frontiers in Medicine (Lausanne), 9, Article ID: 1024762. [Google Scholar] [CrossRef] [PubMed]
[23] Liu, Y., Peng, Z., Liu, S., et al. (2023) Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Non-inferiority Trial. Critical Care Medicine, 51, 1318-1327. [Google Scholar] [CrossRef] 
[24] Liu, Y., Chen, C., Liu, N., et al. (2021) Efficacy and Safety of Ciprofol Sedation in ICU Patients with Mechanical Ventilation: A Clinical Trial Study Protocol. Advances in Therapy, 38, 5412-5423. [Google Scholar] [CrossRef] [PubMed]
[25] Wei, A., Yang, L., Ma, S., Jin, G., Yang, M. and Zhou, J. (2022) A Case Report of Ciprofol Overdose during Anesthesia/Analgesia and Literature Review: Clinical Presentation, Blood Pressure, and Management. Journal of International Medical Research, 50, No. 11. [Google Scholar] [CrossRef] [PubMed]
[26] Hou, L., Zhao, Y., Zhao, S., et al. (2024) Ciprofol Is Primarily Glucuronidated by UGT1A9 and Predicted Not to Cause Drug-Drug Interactions with Typical Substrates of CYP1A2, CYP2B6, and CYP2C19. Chemico-Biological Interactions, 387, Article ID: 110811. [Google Scholar] [CrossRef] [PubMed]
[27] Yang, D.D., et al. (2023) Drug-Drug Interaction Study of Ciprofol and Sodium Divalproex: Pharmacokinetics, Pharmacodynamics, and Safety in Healthy Chinese Subjects. Clinical and Translational Science, 16, 1972-1981. [Google Scholar] [CrossRef] [PubMed]
[28] Teng, Y., Ou, M.C., Wang, X., et al. (2021) Pharmacokinetic and Pharma-codynamic Properties of Ciprofol Emulsion in Chinese Subjects: A Single Center, Open-Label, Single-Arm Dose-Escalation Phase 1 Study. American Journal of Translational Research, 13, 13791-13802.

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