新生儿抗生素研究进展
Progress in Neonatal Antibiotic Research
DOI: 10.12677/ACM.2024.143664, PDF,   
作者: 马晓霞：新疆医科大学儿科学院，新疆 乌鲁木齐；李明霞*：新疆医科大学第一附属医院新生儿科，新疆 乌鲁木齐
关键词: 抗生素；新生儿；抗生素管理；抗菌素耐药性；Antibiotic； Neonatal； Antimicrobial Stewardship； Anti-Microbial Resistance
摘要: 新生儿重症监护室(Neonatal Intensive Care Units, NICU)的抗生素治疗通常始于经验性治疗，在不同的新生儿重症监护病房中差异很大。许多研究都记录了目前NICU不必要的和长期的抗生素治疗现状及所带来的严重副作用，新生儿在生命早期暴露于抗生素会对患儿产生长期不良影响。因此，了解NICU抗生素应用现状，并采用针对性的抗生素的管理措施，希望可以提高患儿的生存质量。
Abstract: Antibiotic therapy in the NICU (Neonatal Intensive Care Units) usually begins empirically and varies greatly from one NICU to another. Many studies have documented the current status of unnecessary and prolonged antibiotic therapy in the NICU and the serious side effects associated with it, and that exposure of newborns to antibiotics early in life can have long-term adverse effects on the child. Therefore, understanding the current status of antibiotic use in the NICU and adopting manage-ment measures that target antibiotics will hopefully improve the quality of survival of children.
文章引用：马晓霞, 李明霞. 新生儿抗生素研究进展[J]. 临床医学进展, 2024, 14(3): 49-54. https://doi.org/10.12677/ACM.2024.143664

参考文献

[1] Perin, J., Mulick, A., Yeung, D., et al. (2022) Global, Regional, and National Causes of Under-5 Mortality in 2000-19: An Updated Systematic Analysis with Implications for the Sustainable Development Goals. The Lancet Child & Adoles-cent Health, 6, 106-115. [Google Scholar] [CrossRef] 
[2] Puopolo, K.M., Benitz, W.E., Zaoutis, T.E., et al. (2018) Management of Neonates Born at
[3] Ting, J.Y., Synnes, A., Roberts, A., et al. (2016) Asso-ciation between Antibiotic Use and Neonatal Mortality and Morbidities in Very Low-Birth-Weight Infants without Cul-ture-Proven Sepsis or Necrotizing Enterocolitis. JAMA Pediatrics, 170, 1181-1187. [Google Scholar] [CrossRef] [PubMed]
[4] Esaiassen, E., Fjalstad, J.W., Juvet, L.K., et al. (2017) Anti-biotic Exposure in Neonates and Early Adverse Outcomes: A Systematic Review and Meta-Analysis. Journal of Antimi-crobial Chemotherapy, 72, 1858-1870. [Google Scholar] [CrossRef] [PubMed]
[5] Gasparrini, A.J., Crofts, T.S., Gibson, M.K., et al. (2016) Antibiotic Per-turbation of the Preterm Infant Gut Microbiome and Resistome. Gut Microbes, 7, 443-449. [Google Scholar] [CrossRef] [PubMed]
[6] Jiang, S., Zhang, L., Yan, W., et al. (2021) Antibiotic Use in Neonatal Intensive Care Units in China: A Multicenter Cohort Study. The Journal of Pediatrics, 239, 136-142E4. [Google Scholar] [CrossRef] [PubMed]
[7] Schulman, J., Dimand, R.J., Lee, H.C., et al. (2015) Neonatal In-tensive Care Unit Antibiotic Use. Pediatrics, 135, 826-833. [Google Scholar] [CrossRef] [PubMed]
[8] Grohskopf, L.A., Huskins, W.C., Sinkowitz-Cochran, R.L., et al. (2005) Use of Antimicrobial Agents in United States Neonatal and Pediatric Intensive Care Patients. The Pediatric Infec-tious Disease Journal, 24, 766-773. [Google Scholar] [CrossRef] [PubMed]
[9] Spencer, H.J.J., Dantuluri, K.L., Thurm, C., et al. (2022) Variation in Antibiotic Use among Neonatal Intensive Care Units in the United States. Infection Control & Hospital Epi-demiology, 43, 1945-1947. [Google Scholar] [CrossRef] [PubMed]
[10] Flannery, D.D., Ross, R.K., Mukhopadhyay, S., et al. (2018) Temporal Trends and Center Variation in Early Antibiotic Use among Premature Infants. JAMA Network Open, 1, E180164. [Google Scholar] [CrossRef] [PubMed]
[11] Ho, T., Buus-Frank, M.E., Edwards, E.M., et al. (2018) Adherence of Newborn-Specific Antibiotic Stewardship Programs to CDC Recommendations. Pediatrics, 142, e20174322. [Google Scholar] [CrossRef] [PubMed]
[12] Ting, J.Y., Roberts, A., Sherlock, R., et al. (2019) Dura-tion of Initial Empirical Antibiotic Therapy and Outcomes in Very Low Birth Weight Infants. Pediatrics, 143, e20182286. [Google Scholar] [CrossRef] [PubMed]
[13] Hou, S., Yu, Y., Wu, Y., et al. (2022) Association between Antibiotic Overexposure and Adverse Outcomes in Very-Low-Birth-Weight Infants without Culture-Proven Sepsis or Necrotizing Enterocolitis: A Multicenter Prospective Study. Indian Journal of Pediatrics, 89, 785-792. [Google Scholar] [CrossRef] [PubMed]
[14] Letouzey, M., Lorthe, E., Marchand-Martin, L., et al. (2022) Early Antibiotic Exposure and Adverse Outcomes in Very Preterm Infants at Low Risk of Early-Onset Sepsis: The EPIPAGE-2 Cohort Study. The Journal of Pediatrics, 243, 91-98E4. [Google Scholar] [CrossRef] [PubMed]
[15] Dhingra, S., Rahman, N.A.A., Peile, E., et al. (2020) Microbial Resistance Movements: An Overview of Global Public Health Threats Posed by Antimicrobial Resistance, and How Best to Counter. Frontiers in Public Health, 8, Article ID: 535668. [Google Scholar] [CrossRef] [PubMed]
[16] Mintz, A., Mor, M., Klinger, G., et al. (2020) Changing Epidemi-ology and Resistance Patterns of Pathogens Causing Neonatal Bacteremia. European Journal of Clinical Microbiology & Infectious Diseases, 39, 1879-1884. [Google Scholar] [CrossRef] [PubMed]
[17] Ramirez, C.B. and Cantey, J.B. (2019) Antibiotic Resistance in the Neonatal Intensive Care Unit. Neoreviews, 20, E135-E144. [Google Scholar] [CrossRef] [PubMed]
[18] Folgori, L., Ellis, S.J., Bielicki, J.A., et al. (2017) Tackling Antimicrobial Resistance in Neonatal Sepsis. The Lancet Global Health, 5, E1066-E1068. [Google Scholar] [CrossRef] 
[19] Laxminarayan, R., Matsoso, P., Pant, S., et al. (2016) Access to Effective Antimicrobials: A Worldwide Challenge. The Lancet, 387, 168-175. [Google Scholar] [CrossRef] 
[20] Li, J.Y., Chen, S.Q., Yan, Y.Y., et al. (2018) Identification and Antimicrobial Resistance of Pathogens in Neonatal Septicemia in China—A Meta-Analysis. International Journal of Infectious Diseases, 71, 89-93. [Google Scholar] [CrossRef] [PubMed]
[21] Gu, S., Lai, J., Kang, W., et al. (2022) Drug Resistance Characteris-tics and Molecular Typing of Escherichia coli Isolates from Neonates in Class A Tertiary Hospitals: A Multicentre Study across China. Journal of Infection, 85, 499-506. [Google Scholar] [CrossRef] [PubMed]
[22] Ren, Z., Yang, S., Han, J., et al. (2023) Reduction of Antibiotic Use and Multi-Drug Resistance Bacteria Infection in Neonates after Improvement of Antibiotics Use Strategy in a Level 4 Neonatal Intensive Care Unit in Southern China. European Journal of Clinical Microbiology & Infectious Diseases, 42, 87-98. [Google Scholar] [CrossRef] [PubMed]
[23] 付盼, 王传清, 俞蕙, 等. 中国儿童细菌耐药监测组2022年儿童细菌耐药监测[J]. 中国循证儿科杂志, 2023, 18(5): 341-348.
[24] 贺小红, 王韶. 新生儿三代头孢菌素耐药肺炎克雷伯菌感染的危险因素研究[J]. 临床研究, 2024, 32(1): 1-4.
[25] Thanabalasuriar, A. and Kubes, P. (2014) Neonates, Antibiotics and the Microbiome. Nature Medicine, 20, 469-470. [Google Scholar] [CrossRef] [PubMed]
[26] Schokker, D., Zhang, J., Zhang, L.L., et al. (2014) Early-Life Environmental Variation Affects Intestinal Microbiota and Immune Development in New-Born Piglets. PLOS ONE, 9, E100040. [Google Scholar] [CrossRef] [PubMed]
[27] Dolma, K., Freeman, A.E., Rezonzew, G., et al. (2020) Effects of Hyperoxia on Alveolar and Pulmonary Vascular Development in Germ-Free Mice. The American Journal of Physiol-ogy-Lung Cellular and Molecular Physiology, 318, L421-L428. [Google Scholar] [CrossRef] [PubMed]
[28] Menden, H., Xia, S., Mabry, S.M., et al. (2019) Histone Deacetylase 6 Regulates Endothelial MyD88-Dependent Canonical TLR Signaling, Lung Inflammation, and Alveolar Remodeling in the Developing Lung. The American Journal of Physiology-Lung Cellular and Molecular Physiology, 317, L332-L346. [Google Scholar] [CrossRef] [PubMed]
[29] Vangay, P., Ward, T., Gerber, J.S., et al. (2015) An-tibiotics, Pediatric Dysbiosis, and Disease. Cell Host & Microbe, 17, 553-564. [Google Scholar] [CrossRef] [PubMed]
[30] Neuman, H., Forsythe, P., Uzan, A., et al. (2018) Antibiotics in Early Life: Dysbiosis and the Damage Done. FEMS Microbiology Reviews, 42, 489-499. [Google Scholar] [CrossRef] [PubMed]
[31] Vallianou, N., Dalamaga, M., Stratigou, T., et al. (2021) Do Antibiotics Cause Obesity through Long-Term Alterations in the Gut Microbiome? A Review of Current Evidence. Current Obesity Reports, 10, 244-262. [Google Scholar] [CrossRef] [PubMed]
[32] Uzan-Yulzari, A., Turta, O., Belogolovski, A., et al. (2021) Neonatal Antibiotic Exposure Impairs Child Growth during the First Six Years of Life by Perturbing Intestinal Microbial Colonization. Nature Communications, 12, Article No. 443. [Google Scholar] [CrossRef] [PubMed]
[33] McGowan, J.E. and Gerding, D.N. (1996) Does Antibiotic Re-striction Prevent Resistance? New Horizons, 4, 370-376.
[34] Principi, N. and Esposito, S. (2016) Antimicrobial Stew-ardship in Paediatrics. BMC Infectious Diseases, 16, Article No. 424. [Google Scholar] [CrossRef] [PubMed]
[35] Chu, M., Lin, J., Wang, M., et al. (2023) Restrictive Use of Em-pirical Antibiotics Is Associated with Improved Short Term Outcomes in Very Low Birth Weight Infants: A Single Cen-ter, Retrospective Cohort Study from China. Antibiotics (Basel), 12, Article No. 741. [Google Scholar] [CrossRef] [PubMed]
[36] Lee, S.Y. and An, S.H. (2022) Impact of Pharmacist Intervention in Antibiotic Stewardship Programmes for Critically Ill Neonates: A Systematic Review and Meta-Analysis. Journal of Clinical Pharmacy and Therapeutics, 47, 430-444. [Google Scholar] [CrossRef] [PubMed]
[37] Cao, G., Zhou, P., Zhang, H., et al. (2022) Extended Infusion of Mero-penem in Neonatal Sepsis: A Historical Cohort Study. Antibiotics (Basel), 11, Article No. 341. [Google Scholar] [CrossRef] [PubMed]

为你推荐