核因子κB激活蛋白与疾病关系的研究进展
Research Progress on the Relationship between NF-κB Activating Protein and Disease
DOI: 10.12677/ACM.2024.143677, PDF,   
作者: 张馨蕾*, 赵雪娜, 舒 政：山东第一医科大学(山东省医学科学院)研究生院，山东 济南；山东第一医科大学第一附属医院(山东省千佛山医院)普通外科学，山东第一医科大学第一附属医院腹腔镜技术实验室，山东省医药卫生普外中心重点实验室，山东 济南；山东第一医科大学第一附属医院(山东省千佛山医院)乳腺外科，山东 济南；张 梅#：山东第一医科大学第一附属医院(山东省千佛山医院)普通外科学，山东第一医科大学第一附属医院腹腔镜技术实验室，山东省医药卫生普外中心重点实验室，山东 济南；山东第一医科大学第一附属医院(山东省千佛山医院)乳腺外科，山东 济南
关键词: 核因子κB激活蛋白；核因子κB；肿瘤；机制；NF-κB Activating Protein； NF-κB； Tumor； Mechanism
摘要: NKAP是一种高度保守的47kD蛋白质，在转录抑制、T细胞发育、成熟和功能获得、造血干细胞的维持和存活以及RNA剪接中发挥重要作用。近年来，对NKAP与疾病发生发展关系的研究越来越多，诸如肺炎、肺癌、乳腺癌、肝细胞癌、结肠癌、肾细胞癌等。多数研究结果表明NKAP作为一个癌基因在肿瘤疾病中发挥作用，其对细胞的增殖、侵袭、迁移有促进作用。但目前对NKAP在疾病中的研究仍较为局限。本文主要就近年来NKAP的研究情况予以综述。
Abstract: NKAP is a highly conserved 47kD protein that plays important roles in transcriptional suppression, T cell development, maturation and functional acquisition, maintenance and survival of hematopoietic stem cells, and RNA splicing. In recent years, more and more studies have been conducted on the relationship between NKAP and the occurrence and development of diseases, such as pneumonia, lung cancer, breast cancer, hepatocellular carcinoma, colon cancer, renal cell carcinoma, etc. Most research results indicate that NKAP plays a role as an oncogene in tumor diseases, promoting cell proliferation, invasion, and migration. However, current research on NKAP in diseases is still relatively limited. This article mainly reviews the research status of NKAP in recent years.
文章引用：张馨蕾, 赵雪娜, 舒政, 张梅. 核因子κB激活蛋白与疾病关系的研究进展[J]. 临床医学进展, 2024, 14(3): 142-148. https://doi.org/10.12677/ACM.2024.143677

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