邻苯二甲酸酯暴露对儿童健康影响的流病学研究进展
Epidemiological Research Progress on Effects of Phthalate Exposure on Children’s Health
DOI: 10.12677/ACM.2024.143683, PDF,    科研立项经费支持
作者: 何东玲, 高思雨, 周甲颖, 张娟利*:西安医学院临床医学院,陕西 西安
关键词: 邻苯二甲酸酯儿童健康环境内分泌干扰物Phthalate Ester Child Health Environmental Endocrine Disruptors
摘要: 近年来,儿童健康问题越来越受关注,儿童健康与遗传、环境等多种因素密切相关。邻苯二甲酸酯(PAEs)作为一种环境激素,可通过皮肤、呼吸、胎盘等多种途径造成儿童多系统疾病,其危害也受到国内外研究者的日益关注,本文通过国内外学者的流行病学调查研究,从儿童过敏性疾病、内分泌疾病、新生儿疾病、神经系统疾病等方面总结了PAEs对儿童健康的不良影响并对未来治疗儿童疾病做出展望。
Abstract: In recent years, more and more attention has been paid to children’s health, which is closely related to genetic, environmental and other factors. Phthalates (PAEs), as an environmental hormone, can cause multi-system diseases in children through skin, respiratory, placenta and other ways, and its harm has attracted increasing attention from researchers at home and abroad. This paper summa-rizes the adverse effects of PAEs on children’s health from children’s allergic diseases, endocrine diseases, neonatal diseases and nervous system diseases, and makes a prospect for the future treatment of children’s diseases.
文章引用:何东玲, 高思雨, 周甲颖, 张娟利. 邻苯二甲酸酯暴露对儿童健康影响的流病学研究进展[J]. 临床医学进展, 2024, 14(3): 181-189. https://doi.org/10.12677/ACM.2024.143683

参考文献

[1] Shoaito, H., et al. (2019) The Role of Peroxisome Proliferator—Activated Receptor Gamma (PPARγ) in Mono (2-ethylhexyl) Phthalate (MEHP)-Mediated Cytotrophoblast Differentiation. Environmental Health Perspectives Journal, 127, Article ID: 27003. [Google Scholar] [CrossRef
[2] Philippat, C., et al. (2019) Prenatal Exposure to Se-lect Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France). Environmental Health Perspectives Journal, 127, Article ID: 17002. [Google Scholar] [CrossRef
[3] Tang, Z.R., Xu, X.L., Deng, S.L., Lian, Z.X. and Yu, K. (2020) Oestrogenic Endocrine Disruptors in the Placenta and the Fetus. International Journal of Molecular Sciences, 21, Article 1519. [Google Scholar] [CrossRef] [PubMed]
[4] 高崇婧, 贾璐璐, 吴鹏冉. 中国居民对邻苯二甲酸酯类增塑剂暴露的现状分析[J]. 暨南大学学报(自然科学与医学版), 2017, 38(2): 93-103.
[5] Benjamin, S., et al. (2017) Phthalates Impact Human Health: Epidemiological Evidences and Plausible Mechanism of Action. Journal of Hazardous Materials, 340, 360-383. [Google Scholar] [CrossRef] [PubMed]
[6] Navaranjan, G., Diamond, M.L., Harris, S.A., et al. (2021) Early Life Exposure to Phthalates and the Development of Childhood Asthma among Canadian Children. En-vironmental Research, 197, Article ID: 110981. [Google Scholar] [CrossRef] [PubMed]
[7] Odebeatu, C.C., Taylor, T., Fleming, L.E. and Osborne, N.J. (2019) Phthalates and Asthma in Children and Adults: US NHANES 2007-2012. Environmental Science and Pollution Research, 26, 28256-28269. [Google Scholar] [CrossRef] [PubMed]
[8] Zhu, C., Sun, Y., Zhao, Y., et al. (2022) Associations between Children’s Asthma and Allergic Symptoms and Phthalates in Dust in Metropolitan Tianjin, China. Chemosphere, 302, Article ID: 134786. [Google Scholar] [CrossRef] [PubMed]
[9] Huang, P.C., Cheng, P.K., Chen, H.C., et al. (2022) Are Phthalate Exposure Related to Oxidative Stress in Children and Adolescents with Asthma? A Cumulative Risk Assess-ment Approach. Antioxidants, 11, Article 1315. [Google Scholar] [CrossRef] [PubMed]
[10] Zhang, J., et al. (2021) Associations between Phthalic Acid Esters in Household Dust and Childhood Asthma in Shanghai, China. Environmental Research, 200, Article ID: 111760. [Google Scholar] [CrossRef] [PubMed]
[11] Vasseghian, Y., Alimohamadi, M., Dragoi, E.N. and Sonne, C. (2023) A Global Meta-Analysis of Phthalate Esters in Drinking Water Sources and Associated Health Risks. Science of the Total Environment, 903, Article ID: 166846. [Google Scholar] [CrossRef] [PubMed]
[12] Jøhnk, C., Høst, A., Husby, S., et al. (2020) Maternal Phthalate Exposure and Asthma, Rhinitis and Eczema in 552 Children Aged 5 Years; A Prospective Cohort Study. Envi-ronmental Health, 19, Article No. 32. [Google Scholar] [CrossRef] [PubMed]
[13] Granum, B., Oftedal, B., Agier, L., et al. (2020) Multiple Envi-ronmental Exposures in Early-Life and Allergy-Related Outcomes in Childhood. Environment International, 144, Article ID: 106038. [Google Scholar] [CrossRef] [PubMed]
[14] Shi, W., et al. (2018) Urinary Phthalate Metabolites in Relation to Childhood Asthmatic and Allergic Symptoms in Shanghai. Environment International, 121, 276-286. [Google Scholar] [CrossRef] [PubMed]
[15] Zhang, J., Sun, C., Lu, R., et al. (2022) Association of Childhood Rhinitis with Phthalate Acid Esters in Household Dust in Shanghai Residences. International Archives of Occupational and Environmental Health, 95, 629-643. [Google Scholar] [CrossRef] [PubMed]
[16] Hashemipour, M., Kelishadi, R., Amin, M.M., et al. (2018) Is There Any Association between Phthalate Exposure and Precocious Puberty in Girls? Environmental Science and Pollu-tion Research, 25, 13589-13596. [Google Scholar] [CrossRef] [PubMed]
[17] Zhou, F., Jin, Z., Zhu, L., et al. (2022) A Preliminary Study on the Relationship between Environmental Endocrine Disruptors and Precocious Puberty in Girls. Journal of Pediatric Endo-crinology & Metabolism, 35, 989-997. [Google Scholar] [CrossRef] [PubMed]
[18] Buluş, A.D., Aşci, A., Erkekoglu, P., et al. (2016) The Evaluation of Possible Role of Endocrine Disruptors in Central and Peripheral Precocious Puberty. Toxicology Mechanisms and Methods, 26, 493-500. [Google Scholar] [CrossRef] [PubMed]
[19] 金薇, 王红丽, 邓庆先, 等. 女童尿液邻苯二甲酸酯水平与性早熟的关系研究[J]. 中国初级卫生保健, 2021, 35(7): 60-62.
[20] Jung, M.K., Choi, H.S., Suh, J., et al. (2019) The Analysis of Endocrine Disruptors in Patients with Central Precocious Puberty. BMC Pediatrics, 19, Article No. 323. [Google Scholar] [CrossRef] [PubMed]
[21] Harley, K.G., Berger, K.P., Kogut, K., et al. (2019) Association of Phthalates, Parabens and Phenols Found in Personal Care Products with Pubertal Timing in Girls and Boys. Human Re-production, 34, 109-117. [Google Scholar] [CrossRef] [PubMed]
[22] Binder, A.M., Corvalan, C., Pereira, A., et al. (2018) Prepubertal and Pubertal Endocrine-Disrupting Chemical Exposure and Breast Density among Chilean Adolescents. Cancer Epidemiolo-gy, Biomarkers & Prevention, 27, 1491-1499. [Google Scholar] [CrossRef
[23] Golestanzadeh, M., Riahi, R. and Kelishadi, R. (2020) Asso-ciation of Phthalate Exposure with Precocious and Delayed Pubertal Timing in Girls and Boys: A Systematic Review and Meta-Analysis. Environmental Science: Processes & Impacts, 22, 873-894. [Google Scholar] [CrossRef
[24] 龚湘玲. 女婴幼儿单纯乳房早发育与环境内分泌干扰物临床相关性研究[D]: [硕士学位论文]. 南昌: 南昌大学, 2018.
[25] 郑秀鑫. 尿邻苯二甲酸酯与女童乳房早发育及其进展关系的研究[D]: [硕士学位论文]. 沈阳: 中国医科大学, 2021.
[26] 黄淑容. 青春发育提前女童骨成熟特征及与邻苯二甲酸酯的相关性研究[D]: [硕士学位论文]. 汕头: 汕头大学, 2021.
[27] Kahn, L.G., Philippat, C., Nakayama, S.F., et al. (2020) Endocrine-Disrupting Chemicals: Implications for Human Health. For, 8, 703-718. [Google Scholar] [CrossRef
[28] Lee, D.W., Lim, H.M., Lee, J.Y., Min, K.B., Shin, C.H., Lee, Y.A. and Hong, Y.C. (2022) Prenatal Exposure to Phthalate and Decreased Body Mass Index of Children: A Systematic Review and Meta-Analysis. Scientific Reports, 12, Article No. 8961. [Google Scholar] [CrossRef] [PubMed]
[29] Zettergren, A., Andersson, N., Larsson, K., et al. (2021) Expo-sure to Environmental Phthalates during Preschool Age and Obesity from Childhood to Young Adulthood. Environmen-tal Research, 192, Article ID: 110249. [Google Scholar] [CrossRef] [PubMed]
[30] Dong, Y., Gao, D., Li, Y., et al. (2022) Effect of Childhood Phthalates Exposure on the Risk of Overweight and Obesity: A Nested Case-Control Study in China. Environment In-ternational, 158, Article ID: 106886. [Google Scholar] [CrossRef] [PubMed]
[31] Wang, Z.H., Gao, D. and Zou, Z.Y. (2023) The Association of Phthalate Metabolites with Childhood Waist Circumference and Abdominal Obesity. European Journal of Pediatrics, 182, 803-812. [Google Scholar] [CrossRef] [PubMed]
[32] Vrijheid, M., Fossati, S., Maitre, L., et al. (2020) Early-Life En-vironmental Exposures and Childhood Obesity: An Exposome-Wide Approach. Environmental Health Perspectives, 128, Article ID: 67009. [Google Scholar] [CrossRef
[33] Chang, W.H., et al. (2021) The Effects of Phthalate Ester Exposure on Hu-man Health: A Review. The Science of the Total Environment, 786, Article ID: 147371. [Google Scholar] [CrossRef] [PubMed]
[34] 杨德红, 张晓玲, 陆晓梅, 等. 居室内灰尘甲状腺激素干扰活性及其成分分析[J]. 中华疾病控制杂志, 2017, 21(1): 84-88.
[35] Morgenstern, R., Whyatt, R.M., Insel, B.J., et al. (2017) Phthalates and Thyroid Function in Preschool Age Children: Sex Specific Associations. Environment Interna-tional, 106, 11-18. [Google Scholar] [CrossRef] [PubMed]
[36] Sur, U., Erkekoglu, P., Bulus, A.D., et al. (2019) Oxidative Stress Markers, Trace Elements, and Endocrine Disrupting Chemicals in Children with Hashimoto’s Thyroiditis. Toxicology Mechanisms and Methods, 29, 633-643. [Google Scholar] [CrossRef] [PubMed]
[37] Kishi, R., Araki, A., Minatoya, M., et al. (2017) The Hok-kaido Birth Cohort Study on Environment and Children’s Health: Cohort Profile-Updated 2017. Environmental Health and Preventive Medicine, 22, Article No. 46. [Google Scholar] [CrossRef] [PubMed]
[38] Zhang, Y., Mustieles, V., Yland, J., et al. (2020) Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes with Preterm Birth. JAMA Network Open, 3, e202159. [Google Scholar] [CrossRef] [PubMed]
[39] Broe, A., Pottegård, A., Hallas, J., et al. (2019) Phthalate Exposure from Drugs during Pregnancy and Possible Risk of Preterm Birth and Small for Gestational Age. European Journal of Obstetrics & Gynecology and Reproductive Biology, 240, 293-299. [Google Scholar] [CrossRef] [PubMed]
[40] Ferguson, K.K., Rosen, E.M., Rosario, Z., et al. (2019) Envi-ronmental Phthalate Exposure and Preterm Birth in the PROTECT Birth Cohort. Environment International, 132, Article ID: 105099. [Google Scholar] [CrossRef] [PubMed]
[41] Gao, H., Wang, Y.F., et al. (2019). Prenatal Phthalate Exposure in Relation to Gestational Age and Preterm Birth in a Prospective Cohort Study. Environmental Research, 176, Article ID: 108530.[CrossRef] [PubMed]
[42] Wu, Y., Wang, J. and Wei, Y. (2022) Maternal Exposure to Endocrine Disrupting Chemicals (EDCs) and Preterm Birth: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis. Environmental Pollution, 292, Article ID: 118264. [Google Scholar] [CrossRef] [PubMed]
[43] Hu, J.M.Y., Arbuckle, T.E., et al. (2020) Associations of Prenatal Urinary Phthalate Exposure with Preterm Birth: The Ma-ternal-Infant Research on Environmental Chemicals (MIREC) Study. Canadian Journal of Public Health, 111, 333-341. [Google Scholar] [CrossRef] [PubMed]
[44] Zhong, Q., Liu, H.L., Fu, H., et al. (2021) Prenatal Exposure to Phthalates with Preterm Birth and Gestational Age: A Systematic Review and Meta-Analysis. Chemosphere, 282, Article ID: 130991. [Google Scholar] [CrossRef] [PubMed]
[45] Zhang, Y.W., Gao, H., Mao, L.J., et al. (2018) Effects of the Phthalate Exposure during Three Gestation Periods on Birth Weight and Their Gender Differences: A Birth Cohort Study in China. Science of the Total Environment, 613-614, 1573-1578. [Google Scholar] [CrossRef] [PubMed]
[46] Strømmen, K., Lyche, J.L., Blakstad, E.W., et al. (2016) In-creased Levels of Phthalates in Very Low Birth Weight Infants with Septicemia and Bronchopulmonary Dysplasia. En-vironment International, 89-90, 228-234. [Google Scholar] [CrossRef] [PubMed]
[47] Wu, L.J., Teng, X.M., Yao, Y.C., et al. (2020) Maternal Precon-ception Phthalate Metabolite Concentrations in Follicular Fluid and Neonatal Birth Weight Conceived by Women Under-going in Vitro Fertilization. Environmental Pollution, 267, Article ID: 115584. [Google Scholar] [CrossRef] [PubMed]
[48] Sathyanarayana, S., Barrett, E., Nguyen, R., et al. (2016) First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study. International Journal of Environmental Research and Public Health, 13, Article 945. [Google Scholar] [CrossRef] [PubMed]
[49] Stevens, D.R., Bommarito, P.A., Keil, A.P., et al. (2022) Urinary Phthalate Metabolite Mixtures in Pregnancy and Fetal Growth: Findings from the Infant Development and the Environ-ment Study. Environment International, 163, Article ID: 107235. [Google Scholar] [CrossRef] [PubMed]
[50] Nassan, F.L., Gunn, J.A., Hill, M.M., et al. (2020) Association of Urinary Concentrations of Phthalate Metabolites with Quinolinic Acid among Women: A Potential Link to Neurologi-cal Disorders. Environment International, 138, Article ID: 105643. [Google Scholar] [CrossRef] [PubMed]
[51] Choi, G., Villanger, G.D., Drover, S.S.M., et al. (2021) Prenatal Phthalate Exposures and Executive Function in Preschool Children. Environment International, 149, Article ID: 106403. [Google Scholar] [CrossRef] [PubMed]
[52] Thistle, J.E., Ramos, A., Roell, K.R., et al. (2022) Prenatal Or-ganophosphorus Pesticide Exposure and Executive Function in Preschool-Aged Children in the Norwegian Mother, Fa-ther and Child Cohort Study (MoBa). Environmental Research, 212, Article ID: 113555. [Google Scholar] [CrossRef] [PubMed]
[53] 许思楠, 郭剑秋, 张济明, 朱效宁, 刘萍, 王彦娜, 常秀丽, 邬春华, 周志俊. 邻苯二甲酸酯暴露与2岁幼儿神经发育的关联[J]. 环境与职业医学, 2021, 38(9): 972-978.
[54] Haggerty, D.K., Strakovsky, R.S., Talge, N.M., et al. (2021) Prenatal Phthalate Exposures and Autism Spectrum Disorder Symptoms in Low-Risk Children. Neurotoxicology and Teratology, 83, Article ID: 106947. [Google Scholar] [CrossRef] [PubMed]
[55] Day, D.B., Collett, B.R., Barrett, E.S., et al. (2021) Phthalate Mix-tures in Pregnancy, Autistic Traits, and Adverse Childhood Behavioral Outcomes. Environment International, 147, Arti-cle ID: 106330. [Google Scholar] [CrossRef] [PubMed]
[56] Salthammer, T. (2020) Emerging Indoor Pollutants. International Journal of Hygiene and Environmental Health, 224, Article ID: 113423. [Google Scholar] [CrossRef] [PubMed]