术前外周血参数对肌层浸润性膀胱癌的研究进展
Research Progress of Preoperative Peripheral Blood Parameters in Muscle-Invasive Bladder Cancer
DOI: 10.12677/ACM.2024.143687, PDF,   
作者: 马婷婷, 张瑞丽：新疆医科大学第一附属医院肿瘤中心，新疆 乌鲁木齐
关键词: 肌层浸润性膀胱癌；NLR；PLR；预后；Muscle-Invasive Bladder Cancer； NLR； PLR； Prognosis
摘要: 肌层浸润性膀胱癌(MIBC)具有侵袭性高、预后差的特点。近几年越来越多的临床工作者开始关注炎症反应与肿瘤的关系，并取得了相关成果。许多国内外研究证实了炎症反应在肿瘤的发生、发展以及远处转移过程中发挥着重要作用。在膀胱癌中，系统性炎性反应与预后也存在着相关性。许多研究证实了术前外周血血小板、中性粒细胞、淋巴细胞、白细胞的计数、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)等血常规标记物与膀胱癌患者远处转移及预后有关。其中，中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)是最受临床工作者关注的生物学指标，许多国内外的文章均证实了NLR、PLR与肿瘤的临床病理特征有关，是预测肿瘤患者预后的重要生物学指标，本文就外周血参数在肿瘤发生发展过程作用以及在肌层浸润性膀胱尿路上皮癌中的预后评估价值的研究进展作一综述。
Abstract: Muscle-invasive bladder cancer (MIBC) has the characteristics of high aggressiveness and poor prognosis. In recent years, more and more clinical workers began to pay attention to the relation-ship between inflammation and tumor, and achieved related results. Many domestic and foreign studies have confirmed that inflammation plays an important role in the occurrence, development and distant metastasis of tumors. In bladder cancer, systemic inflammatory response is also associ-ated with prognosis. Many studies have confirmed that preoperative peripheral blood platelet, neutrophil, lymphocyte, white blood cell count, neutrophil-to-lymphocyte ratio (NLR), plate-let-to-lymphocyte ratio (PLR) and other blood routine markers are related to distant metastasis and prognosis of bladder cancer patients. Among them, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are the most concerned biological indicators by clinical workers. Many domestic and foreign articles have confirmed that NLR, PLR are related to the clinicopatho-logical characteristics of tumors, and are important biological indicators for predicting the progno-sis of tumor patients. This article reviews the role of peripheral blood parameters in the occurrence and development of tumors and the prognostic evaluation value in muscle-invasive bladder urothe-lial carcinoma.
文章引用：马婷婷, 张瑞丽. 术前外周血参数对肌层浸润性膀胱癌的研究进展[J]. 临床医学进展, 2024, 14(3): 214-221. https://doi.org/10.12677/ACM.2024.143687

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