白藜芦醇防治脑缺血再灌注损伤的作用机制研究进展
Research Progress on the Mechanism of Resveratrol in the Prevention and Treatment of Cerebral Ischemia-Reperfusion Injury
DOI: 10.12677/ACM.2024.143689, PDF,    科研立项经费支持
作者: 陈瑾瑜：内蒙古医科大学包头临床医学院，内蒙古 包头；刘佳慧*：内蒙古医科大学包头临床医学院，内蒙古 包头；包头市中心医院神经内科，内蒙古 包头
关键词: 白藜芦醇；脑缺血再灌注；Resveratrol； Cerebral Ischemia-Reperfusion
摘要: 脑卒中是临床最常见的神经科疾病之一，也是成人致死和致残的第二大病因，其中近80%是缺血性脑卒中。尽快恢复脑组织的血流供应，目前被认为是最为有意义的治疗急性脑缺血的方法，但脑的缺血区恢复血流灌注后反而加重脑组织损伤，出现“二次”脑损伤，即脑缺血/再灌注损伤。有效干预脑缺血/再灌注损伤对治疗缺血性脑血管病意义重大。白藜芦醇是一种天然的植物抗毒素，主要存在于谷物，水果，蔬菜，干豆类和植物衍生饮料中，包括茶，咖啡和葡萄酒，白藜芦醇具有神经保护，心脏保护，肝肾肺保护，抗糖尿病，抗肥胖等多种作用。本文就白藜芦醇防治脑缺血再灌注损伤的作用机制进行研究。
Abstract: Stroke is one of the most common neurological diseases in clinical practice and the second leading cause of death and disability in adults, with nearly 80% of them being ischemic stroke. Restoring blood supply to brain tissue as soon as possible is currently considered to be the most meaningful treatment for acute cerebral ischemia, but the restoration of blood perfusion in the ischemic area of the brain aggravates brain tissue injury, resulting in “secondary” brain injury, i.e., cerebral ische-mia/reperfusion injury. Effective intervention in cerebral ischemia/reperfusion injury is of great significance for the treatment of ischemic cerebrovascular disease. Resveratrol is a natural plant antitoxin, mainly found in cereals, fruits, vegetables, dried legumes and plant-derived beverages, including tea, coffee and wine. Resveratrol has a variety of beneficial effects such as cardioprotective, hepato-renal and lung-protective, anti-diabetic and anti-obesity.
文章引用：陈瑾瑜, 刘佳慧. 白藜芦醇防治脑缺血再灌注损伤的作用机制研究进展[J]. 临床医学进展, 2024, 14(3): 228-233. https://doi.org/10.12677/ACM.2024.143689

参考文献

[1] 费菲. 王陇德、巢葆华: 改变中国卒中救治面貌的十年——2019年中国脑卒中大会展示10年卒中中心建设的现状和愿景[J]. 中国医药科学, 2019, 9(11): 1-4.
[2] Doyle, K.P., Simon, R.P. and Stenzel-Poore, M.P. (2008) Mecha-nisms of Ischemic Brain Damage. Neuropharmacology, 55, 310-318. [Google Scholar] [CrossRef] [PubMed]
[3] Liao, S., Luo, C., Cao, B., Hu, H., Wang, S., Yue, H., Chen, L. and Zhou, Z. (2017) Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Applica-tion. Stem Cells International, 2017, Article ID: 2193432. [Google Scholar] [CrossRef] [PubMed]
[4] Van Erp, A.C., Rebolledo, R.A., Hoeksma, D., Jespersen, N.R., Ottens, P.J., Norregaard, R., Pedersen, M., Laustsen, C., Burgerhof, J.G.M., Wolters, J.C., Ciapaite, J., Botker, H.E., Leuvenink, H.G.D. and Jespersen, B. (2018) Organ-Specific Responses during Brain Death: Increased Aerobic Metabolism in the Liver and Anaerobic Metabolism with Decreased Perfusion in the Kidneys. Scientific Reports, 8, Article No. 4405. [Google Scholar] [CrossRef] [PubMed]
[5] Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Davalos, A., Guidetti, D., Larrue, V., Lees, K.R., Medeghri, Z., Machnig, T., Schneider, D., von Kummer, R., Wahlgren, N. and Toni, E. (2008) Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. The New England Journal of Medi-cine, 359, 1317-1329. [Google Scholar] [CrossRef] 
[6] Lopez, M.S., Dempsey, R.J. and Vemuganti, R. (2015) Resveratrol Neuroprotection in Stroke and Traumatic CNS Injury. Neurochemistry International, 89, 75-82. [Google Scholar] [CrossRef] [PubMed]
[7] Drygalski, K., Fereniec, E., Korycinski, K., Chomentowski, A., Kielczewska, A., Odrzygozdz, C. and Modzelewska, B. (2018) Resveratrol and Alzheimer’s Disease. From Molecular Pathophysiology to Clinical Trials. Experimental Gerontology, 113, 36-47. [Google Scholar] [CrossRef] [PubMed]
[8] Shen, C., Cheng, W., Yu, P., Wang, L., Zhou, L., Zeng, L. and Yang, Q. (2016) Resveratrol Pretreatment Attenuates Injury and Promotes Proliferation of Neural Stem Cells Following Oxygen-Glucose Deprivation/Reoxygenation by Upregulating the Expression of Nrf2, HO-1 and NQO1 in Vitro. Mo-lecular Medicine Reports, 14, 3646-3654. [Google Scholar] [CrossRef] [PubMed]
[9] Broussalis, E., Trinka, E., Killer, M., Harrer, A., McCoy, M. and Kraus, J. (2012) Current Therapies in Ischemic Stroke. Part B. Future Candidates in Stroke Therapy and Experimental Studies. Drug Discovery Today, 17, 671-684. [Google Scholar] [CrossRef] [PubMed]
[10] Chouchani, E.T., Pell, V.R., Gaude, E., Aksentijevic, D., Sundier, S.Y., Robb, E.L., et al. (2014) Ischaemic Accumulation of Succinate Controls Reperfusion Injury through Mitochondrial ROS. Nature, 515, 431-435. [Google Scholar] [CrossRef] [PubMed]
[11] Lai, R.Y., Shao, Z.W., Yu, H.Q., Li, L.L., Mei, Y. and He, Y. (2014) Design and Application of Psychological Intervention Paths for Ascites Type of Advanced Schistosomiasis Patients. Chinese Journal of Schistosomiasis Control, 26, 662-664.
[12] Nicolas, J., Hendriksen, P.J., Gerssen, A., Bovee, T.F. and Rietjens, I.M. (2014) Marine Neurotoxins: State of the Art, Bottlenecks, and Perspectives for Mode of Action Based Methods of Detection in Seafood. Molecular Nutrition & Food Research, 58, 87-100. [Google Scholar] [CrossRef] [PubMed]
[13] Lei, J. and Chen, Q. (2018) Resveratrol Attenuates Brain Damage in Permanent Focal Cerebral Ischemia via Activation of PI3K/Akt Signaling Pathway in Rats. Neurological Research, 40, 1014-1020. [Google Scholar] [CrossRef] [PubMed]
[14] 雷军荣, 涂献坤, 张华斌, 等. 白藜芦醇通过激活PI3K/Akt信号通路减轻大鼠脑缺血再灌注损伤[J]. 中国临床神经外科杂志, 2016, 21(7): 425-428.
[15] Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., et al. (2007) The Relationship between Helicobac-ter pylori Infection and Promoter Polymorphism of the Nrf2 Gene in Chronic Gastritis. International Journal of Molecu-lar Medicine, 19, 143-148. [Google Scholar] [CrossRef] 
[16] Zhang, R., Xu, M., Wang, Y., Xie, F., Zhang, G. and Qin, X. (2017) Nrf2—A Promising Therapeutic Target for Defensing against Oxidative Stress in Stroke. Molecular Neurobiology, 54, 6006-6017. [Google Scholar] [CrossRef] [PubMed]
[17] Cui, B., Zhang, S., Wang, Y. and Guo, Y. (2019) Farrerol Atten-uates Beta-Amyloid-Induced Oxidative Stress and Inflammation through Nrf2/Keap1 Pathway in a Microglia Cell Line. Biomedicine & Pharmacotherapy, 109, 112-119. [Google Scholar] [CrossRef] [PubMed]
[18] Waza, A.A., Hamid, Z., Ali, S., Bhat, S.A. and Bhat, M.A. (2018) A Review on Heme Oxygenase-1 Induction: Is It a Necessary Evil. Inflammation Research, 67, 579-588. [Google Scholar] [CrossRef] [PubMed]
[19] Liang, M., Wang, Z., Li, H., Cai, L., Pan, J., He, H., et al. (2018) l-Arginine Induces Antioxidant Response to Prevent Oxidative Stress via Stimulation of Glutathione Synthesis and Acti-vation of Nrf2 Pathway. Food and Chemical Toxicology, 115, 315-328. [Google Scholar] [CrossRef] [PubMed]
[20] Qiao, Y.Q., Jiang, P.F. and Gao, Y.Z. (2018) Lutein Prevents Oste-oarthritis through Nrf2 Activation and Downregulation of Inflammation. Archives of Medical Science, 14, 617-624. [Google Scholar] [CrossRef] [PubMed]
[21] Tsai, S.K., Hung, L.M., Fu, Y.T., Cheng, H., Nien, M.W., Liu, H.Y., Zhang, F.B. and Huang, S.S. (2007) Resveratrol Neuroprotective Effects during Focal Cerebral Ischemia Injury via Nitric Oxide Mechanism in Rats. Journal of Vascular Surgery, 46, 346-353. [Google Scholar] [CrossRef] [PubMed]
[22] Ren, J., Fan, C., Chen, N., Huang, J. and Yang, Q. (2011) Resvera-trol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats. Neurochemical Research, 36, 2352-2362. [Google Scholar] [CrossRef] [PubMed]
[23] Tang, F., Guo, S., Liao, H., Yu, P., Wang, L., Song, X., Chen, J. and Yang, Q. (2017) Resveratrol Enhances Neurite Outgrowth and Synaptogenesis via Sonic Hedgehog Signaling Following Oxygen-Glucose Deprivation/Reoxygenation Injury. Cel-lular Physiology and Biochemistry, 43, 852-869. [Google Scholar] [CrossRef] [PubMed]
[24] Yu, P., Wang, L., Tang, F., Zeng, L., Zhou, L., Song, X., Jia, W., Chen, J. and Yang, Q. (2017) Resveratrol Pretreatment Decreases Ischemic In-jury and Improves Neurological Function via Sonic Hedgehog Signaling after Stroke in Rats. Molecular Neurobiology, 54, 212-226. [Google Scholar] [CrossRef] [PubMed]
[25] He, Q., Li, Z., Wang, Y., Hou, Y., Li, L. and Zhao, J. (2017) Resveratrol Alleviates Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting NLRP3 Inflammasome Activa-tion through Sirt1-Dependent Autophagy Induction. International Immunopharmacology, 50, 208-215. [Google Scholar] [CrossRef] [PubMed]
[26] Gouwy, M., Struyf, S., Proost, P. and Van Damme, J. (2005) Synergy in Cytokine and Chemokine Networks Amplifies the Inflammatory Response. Cytokine & Growth Factor Re-views, 16, 561-580. [Google Scholar] [CrossRef] [PubMed]
[27] Rock, R.B., Gekker, G., Hu, S., Sheng, W.S., Cheeran, M., Lokensgard, J.R. and Peterson, P.K. (2004) Role of Microglia in Central Nervous System Infections. Clinical Microbi-ology Reviews, 17, 942-964. [Google Scholar] [CrossRef] 
[28] Yasuda, Y., Shimoda, T., Uno, K., Tateishi, N., Furuya, S., Tsuchihashi, Y., Kawai, Y., Naruse, S. and Fujita, S. (2011) Temporal and Sequential Changes of Glial Cells and Cyto-kine Expression during Neuronal Degeneration after Transient Global Ischemia in Rats. Journal of Neuroinflammation, 8, Article No. 70. [Google Scholar] [CrossRef] [PubMed]
[29] Long, Y., Yang, Q., Xiang, Y., Zhang, Y., Wan, J., Liu, S., Li, N. and Peng, W. (2020) Nose to Brain Drug Delivery—A Promising Strategy for Active Components from Herbal Medi-cine for Treating Cerebral Ischemia Reperfusion. Pharmacological Research, 159, Article ID: 104795. [Google Scholar] [CrossRef] [PubMed]
[30] Garrigue, P., Mounien, L., Champion, S., Mouhajir, Y., Pechere, L., Guillet, B., Landrier, J.F. and Seree, E. (2021) Long-Term Administration of Resveratrol at Low Doses Improves Neurocognitive Performance as Well as Cerebral Blood Flow and Modulates the Inflammatory Pathways in the Brain. The Journal of Nutritional Biochemistry, 97, Article ID: 108786. [Google Scholar] [CrossRef] [PubMed]
[31] Grewal, A.K., Singh, N. and Singh, T.G. (2019) Effects of Resveratrol Postconditioning on Cerebral Ischemia in Mice: Role of the Sirtuin-1 Pathway. The Canadian Journal of Physiology and Pharmacology, 97, 1094-1101. [Google Scholar] [CrossRef] [PubMed]

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