视交叉上核神经元递质释放与弛豫速率的异质关系对导引的影响研究
Research on the Impact of Heterogeneous Relationship between Neurotransmitter Release and Relaxation Rates on the Entrainment of the SCN Neurons
DOI: 10.12677/MOS.2024.132106, PDF,    国家自然科学基金支持
作者: 陈宣羽, 顾长贵*, 席雨菲：上海理工大学管理学院，上海
关键词: 视交叉上核；导引范围；神经递质；弛豫速率；平均场；Suprachiasmatic Nucleus； Entrainment Range； Neurotransmitters； Relaxation Rate； Mean-Field
摘要: 哺乳动物通过大脑视交叉上核(SCN)的调控实现对外部光暗循环的适应。研究发现，SCN神经元主要通过神经递质耦合，且释放神经递质的强度有所差异。本文基于改进的Poincaré模型，考虑在SCN神经元弛豫速率(对外部振幅扰动的刚性)存在不同的条件下，它们释放神经递质的强度差异对SCN网络导引范围的影响。数值模拟结果和理论分析表明，在只有一部分神经元对光信息敏感的情况，在适当的释放差异时导引范围达到最大。本文的发现可能对SCN神经元的异质性和导引能力之间的关系提供一种新的解释，揭示不同SCN神经元递质释放强度的影响。
Abstract: The entrainment of the mammal to the external light-dark cycle is obtained from the orchestration of the suprachiasmatic nucleus (SCN) in the brain. Research has found that SCN neurons are coupled mainly through neurotransmitters, and the releasing magnitude of neurotransmitter varies. Based on a modified Poincaré model, the article considers the impact of differences in the neurotransmit-ter contribution on the entrainment range of SCN network in terms of heterogeneous relaxation rate (rigidity of external amplitude disturbance). The numerical simulation results and theoretical analysis indicate that in the case where only a subpopulation is sensitive to light information, the entrainment range reaches its maximum at certain values of difference. The findings may provide a new explanation for the relationship between heterogeneity and entrainability of SCN neurons, re-vealing the influence of different neurotransmitter contributions of SCN neurons.
文章引用：陈宣羽, 顾长贵, 席雨菲. 视交叉上核神经元递质释放与弛豫速率的异质关系对导引的影响研究[J]. 建模与仿真, 2024, 13(2): 1124-1131. https://doi.org/10.12677/MOS.2024.132106

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