草酸艾司西酞普兰联合用药研究进展

Research Progress of Escitalopram Oxalate Combination Medication

摘要: 草酸艾司西酞普兰作为典型的选择性5-羟色胺再摄取抑制剂类药物的一种，其有着疗效确切、适应范围广、耐受性安全性好、不良反应少的特点，但单纯使用该药很难迅速改善患者的临床症状。若患者仅依靠该药物治疗则需配合较大剂量，最终仍有可能治疗效果不佳。并且患者停药之后可能会出现恶心、腹泻等消化系统症状，易产生药物依赖，从而降低疗效。因此，目前已有多项研究表明联合用药可增强临床疗效，且不增加药物不良反应。

Abstract: As a typical selective serotonin reuptake inhibitor, escitalopram oxalate has the characteristics of definite efficacy, wide range of adaptation, good safety and few adverse reactions. However, it is dif-ficult to rapidly improve the clinical symptoms of patients by using this drug alone. If the patient only relies on the drug, with a larger dose, the treatment may not be effective. In addition, patients may have nausea, diarrhea and other digestive symptoms after stopping withdrawal, which makes it easy to produce drug dependence, thus reducing the efficacy. Therefore, several studies have shown that the combination can enhance clinical efficacy without increasing adverse drug effects.