巨噬细胞极化通路及相关疾病的研究
Study on Macrophage Polarization Pathway and Related Diseases
DOI: 10.12677/ACM.2024.143697, PDF,  被引量   
作者: 马丽莎, 刘纪元, 何惠宇*:新疆医科大学第一附属医院(附属口腔医院)口腔修复科,新疆 乌鲁木齐;新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐
关键词: 巨噬细胞极化经典激活替代激活信号通路Macrophage Polarization Classical Activation Alternative Activation Signal Path
摘要: 巨噬细胞是从血浆单核细胞中分离出来的一种相对稳定的异质免疫细胞,在维持稳定的环境、宿主防御、吞噬和免疫信息传递方面具有一定的作用。受到多种环境因素的作用,巨噬细胞可以被极化为Ml和M2,而且这一变化是可逆的。巨噬细胞极化的特殊表型可以在缓解或治愈疾病中发挥作用,而极化过程受到不同信号通路刺激的影响。本章将回顾极化的经典类型,最重要的信息通路和调控机制,试图为后续的调控和病变的发生和进展提供基础。
Abstract: Macrophages are relatively stable heterogeneous immune cells isolated from plasma monocytes, which play a role in maintaining a stable environment, host defense, phagocytosis and immune in-formation transmission. Macrophages can be polarized into Ml and M2 by a variety of environmen-tal factors, and this change is reversible. The specific phenotype of macrophage polarization can play a role in alleviating or curing disease, and the polarization process is influenced by stimulation of different signaling pathways. This chapter will review the classical types of polarization, the most important information pathways, and regulatory mechanisms in an attempt to provide a basis for subsequent regulation and the occurrence and progression of lesions.
文章引用:马丽莎, 刘纪元, 何惠宇. 巨噬细胞极化通路及相关疾病的研究[J]. 临床医学进展, 2024, 14(3): 276-283. https://doi.org/10.12677/ACM.2024.143697

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