内镜十二指肠空肠套管在治疗肥胖合并2型糖尿病中的应用

Application of Endoscopic Duodenal-Jejunal Bypass Sleeve in the Treatment of Obesity Combined with Type 2 Diabetes Mellitus

摘要: 肥胖症(Obesity)已成为全球最常见的流行病之一，其发病率仍然在持续增加。肥胖合并代谢性疾病已严重威胁了人类健康，尤其是合并2型糖尿病(T2DM)。目前，手术已成为治疗肥胖合并2型糖尿病的最有效的手段。随着减重代谢手术的快速发展，内镜下十二指肠–空肠套管置入术(EDJBS)被给予广泛关注，其非侵入性和可逆性等特点使其成为未来减重代谢手术的重要方向。因为研究较少和不良反应发生率较高的原因，EDJBS尚未在国内广泛使用。相信随着手术的不断推广、外科医生的技能不断提升、装置材料的不断改善、改善体重和代谢的机制不断挖掘，EDJBS也将逐步在国内得到开展，从而对减重代谢外科的发展和T2DM的治愈产生深远影响。该文针对EDJBS术式的发展历史、作用机制和不良反应等方面进行综述。

Abstract: Obesity has become one of the most common epidemics in the world, and its incidence is still in-creasing. Obesity combined with metabolic diseases has seriously threatened human health, espe-cially type 2 diabetes mellitus (T2DM). At present, surgery has become the most effective means of treating obesity with type 2 diabetes. With the rapid development of bariatric and metabolic sur-gery, endoscopic duodenal-jejunal bypass sleeve (EDJBS) has received extensive attention, and its non-invasive and reversible characteristics make it an important direction for bariatric and meta-bolic surgery in the future. EDJBS has not been widely used in China because of few studies and high incidence of adverse reactions. It is believed that with the continuous promotion of surgery, the continuous improvement of surgeons’ skills, the continuous improvement of device materials and the continuous exploration of mechanisms for improving body weight and metabolism, EDJBS will also be gradually carried out in China, which will have a profound impact on the development of bariatric and metabolic surgery and the cure of diabetes. This article reviews the development his-tory, mechanism of action and adverse reactions of EDJBA.