基因科学在军事医学中的应用与挑战
Application and Challenges of Genetic Science in Military Medicine
DOI: 10.12677/ACM.2024.143702, PDF,   
作者: 王子强*:山东第二医科大学临床医学院,山东 潍坊;孙树军:潍坊医学院附属医院耳鼻咽喉科,山东 潍坊
关键词: 基因科学军事医学应用挑战Genetic Science Military Medicine Application Challenges
摘要: 军事医学作为一种特殊的医学科学,对军事及国防安全的重要性不言而喻。随着基因科学的迅猛发展,其应用日渐覆盖多个领域。基因科学为士兵筛选及部署、战伤救治、提高特殊环境的耐受能力以及预防和治疗创伤后应激障碍带来了革命性的变化,同时也带来了新的挑战。重视研究潜在机制,合理地使用基因武器,才能应对现代战争面临的更复杂情况,保障国防安全。
Abstract: As a special medical science, military medicine is of great importance to military and national de-fense security. With the rapid development of genetic science, the application has gradually covered multiple fields. Genetic science has revolutionized the selection and deployment of soldiers, the treatment of war wounds, the improvement of tolerance in special environments, and the preven-tion and treatment of post-traumatic stress disorder, as well as brings new challenges. Only by pay-ing attention to the research of potential mechanisms and using genetic weapons reasonably can we cope with the more complex situations faced by modern warfare and ensure national defense secu-rity.
文章引用:王子强, 孙树军. 基因科学在军事医学中的应用与挑战[J]. 临床医学进展, 2024, 14(3): 311-317. https://doi.org/10.12677/ACM.2024.143702

参考文献

[1] De Castro, M., Biesecker, L.G., Turner, C., et al. (2016) Genomic Medicine in the Military. NPJ Genomic Medicine, 1, Article No. 15008. [Google Scholar] [CrossRef] [PubMed]
[2] Oliveira, M., Mason-Buck, G., Ballard, D., et al. (2020) Biowarfare, Bioterrorism and Biocrime: A Historical Overview on Microbial Harmful Applications. Forensic Science International, 314, Article ID: 110366. [Google Scholar] [CrossRef] [PubMed]
[3] Zilinskas, R.A. (1997) Iraq’s Biological Weapons: The Past as Future? JAMA, 278, 418-424. [Google Scholar] [CrossRef] [PubMed]
[4] Flibbert, A. (2003) After Saddam: Regional Insecurity, Weapons of Mass Destruction, and Proliferation Pressures in Postwar Iraq. Political Science Quarterly, 118, 547-567. [Google Scholar] [CrossRef
[5] Liu, G.D., Wang, N., Wang, H.M., et al. (2021) Military Medical Research on Internal Diseases in Modern Warfare: New Concepts, Demands, Challenges, and Opportunities. Military Medical Research, 8, Article No. 20. [Google Scholar] [CrossRef] [PubMed]
[6] Biesecker, L.G. and Green, R.C. (2014) Diagnostic Clinical Ge-nome and Exome Sequencing. The New England Journal of Medicine, 370, 2418-2425. [Google Scholar] [CrossRef
[7] Mehlman, M.J. and Li, T.Y. (2014) Ethical, Legal, Social, and Policy Issues in the Use of Genomic Technology by the U.S. Military. Journal of Law and the Biosciences, 1, 244-280. [Google Scholar] [CrossRef] [PubMed]
[8] Baruch, S. and Hudson, K. (2008) Civilian and Military Genetics: Nondis-crimination Policy in a Post-GINA World. The American Journal of Human Genetics, 83, 435-444. [Google Scholar] [CrossRef] [PubMed]
[9] Kark, J.A., Posey, D.M., Schumacher, H.R., et al. (1987) Sick-le-Cell Trait as a Risk Factor for Sudden Death in Physical Training. The New England Journal of Medicine, 317, 781-787. [Google Scholar] [CrossRef
[10] Webber, B.J. and Witkop, C.T. (2014) Screening for Sickle-Cell Trait at Accession to the United States Military. Military Medicine, 179, 1184-1189. [Google Scholar] [CrossRef
[11] O’Connor, F.G., Bergeron, M.F., Cantrell, J., et al. (2012) ACSM and CHAMP Summit on Sickle Cell Trait: Mitigating Risks for Warfighters and Athletes. Medicine & Science in Sports & Exercise, 44, 2045-2056. [Google Scholar] [CrossRef
[12] Vahey, M.T., Nau, M.E., Jagodzinski, L.L., et al. (2002) Impact of Viral Infection on the Gene Expression Profiles of Proliferating Normal Human Peripheral Blood Mononuclear Cells Infected with HIV Type 1 RF. AIDS Research and Human Retroviruses, 18, 179-192. [Google Scholar] [CrossRef] [PubMed]
[13] Miao, X.R., Chen, Q.B., Wei, K., et al. (2018) Posttraumatic Stress Disorder: from Diagnosis to Prevention. Military Medical Research, 5, Article No. 32. [Google Scholar] [CrossRef] [PubMed]
[14] Reijnen, A., Rademaker, A.R., Vermetten, E., et al. (2015) Preva-lence of Mental Health Symptoms in Dutch Military Personnel Returning from Deployment to Afghanistan: A 2-Year Longitudinal Analysis. European Psychiatry, 30, 341-346. [Google Scholar] [CrossRef] [PubMed]
[15] Sundin, J., Herrell, R.K., Hoge, C.W., et al. (2014) Mental Health Outcomes in US and UK Military Personnel Returning from Iraq. The British Journal of Psychiatry, 204, 200-207. [Google Scholar] [CrossRef] [PubMed]
[16] Macgregor, A.J., Tang, J.J., Dougherty, A.L., et al. (2013) Deployment-Related Injury and Posttraumatic Stress Disorder in US Military Personnel. Injury, 44, 1458-1464. [Google Scholar] [CrossRef] [PubMed]
[17] Sandweiss, D.A., Slymen, D.J., Leardmann, C.A., et al. (2011) Preinjury Psychiatric Status, Injury Severity, and Postdeployment Posttraumatic Stress Disorder. Archives of General Psychiatry, 68, 496-504. [Google Scholar] [CrossRef] [PubMed]
[18] Pattinson, C.L., Guedes, V.A., Edwards, K., et al. (2020) Excessive Daytime Sleepiness Is Associated with Altered Gene Expression in Military Personnel and Veterans with Posttraumatic Stress Disorder: An RNA Sequencing Study. Sleep, 43, zsaa036. [Google Scholar] [CrossRef] [PubMed]
[19] Malan-Muller, S., Seedat, S. and Hemmings, S.M. (2014) Understand-ing Posttraumatic Stress Disorder: Insights from the Methylome. Genes, Brain and Behavior, 13, 52-68. [Google Scholar] [CrossRef] [PubMed]
[20] Cornelis, M.C., Nugent, N.R., Amstadter, A.B., et al. (2010) Genetics of Post-Traumatic Stress Disorder: Review and Recommendations for Genome-Wide Association Studies. Current Psychi-atry Reports, 12, 313-326. [Google Scholar] [CrossRef] [PubMed]
[21] Wang, Y., Karstoft, K.I., Nievergelt, C.M., et al. (2019) Post-Traumatic Stress Following Military Deployment: Genetic Associations and Cross-Disorder Genetic Correlations. Journal of Affective Disorders, 252, 350-357. [Google Scholar] [CrossRef] [PubMed]
[22] Nass, J. and Efferth, T. (2017) Pharmacogenetics and Pharma-cotherapy of Military Personnel Suffering from Post- Traumatic Stress Disorder. Current Neuropharmacology, 15, 831-860. [Google Scholar] [CrossRef
[23] Sheerin, C.M., Lind, M.J., Bountress, K.E., et al. (2017) The Genetics and Epigenetics of PTSD: Overview, Recent Advances, and Future Directions. Current Opinion in Psychology, 14, 5-11. [Google Scholar] [CrossRef] [PubMed]
[24] Walsh, T., Lee, M.K., Casadei, S., et al. (2010) Detection of In-herited Mutations for Breast and Ovarian Cancer Using Genomic Capture and Massively Parallel Sequencing. Proceed-ings of the National Academy of Sciences of the United States of America, 107, 12629-12633. [Google Scholar] [CrossRef] [PubMed]
[25] De Castro, M.J. and Turner, C.E. (2017) Military Genomics: A Perspective on the Successes and Challenges of Genomic Medicine in the Armed Services. Molecular Genetics & Ge-nomic Medicine, 5, 617-620. [Google Scholar] [CrossRef] [PubMed]
[26] Lazaro-Munoz, G. and Juengst, E.T. (2015) Challenges for Implementing a PTSD Preventive Genomic Sequencing Program in the U.S. Military. The Case Western Reserve Journal of Internation-al Law, 47, 87-113.
[27] Singh, A.K., Bishayee, A. and Pandey, A.K. (2018) Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy. Nutrients, 10, Article No. 731. [Google Scholar] [CrossRef] [PubMed]
[28] Russo, R., Kemp, M., Bhatti, U.F., et al. (2020) Life on the Battlefield: Valproic Acid for Combat Applications. Journal of Trauma and Acute Care Surgery, 89, S69-S76. [Google Scholar] [CrossRef
[29] Draghici, S., Chen, D. and Reifman, J. (2004) Applications and Challenges of DNA Microarray Technology in Military Medical Research. Military Medicine, 169, 654-659. [Google Scholar] [CrossRef
[30] Halaweish, I., Nikolian, V., Georgoff, P., et al. (2015) Creating a “Prosurvival Phenotype” through Histone Deacetylase Inhibition: Past, Present, and Future. Shock, 44, 6-16. [Google Scholar] [CrossRef
[31] Bhatti, U.F., Williams, A.M., Georgoff, P.E., et al. (2019) The “Omics” of Epigenetic Modulation by Valproic Acid Treatment in Traumatic Brain Injury-What We Know and What the Future Holds. Proteomics: Clinical Applications, 13, e1900068. [Google Scholar] [CrossRef] [PubMed]
[32] Ferguson, M., Byrnes, C., Sun, L., et al. (2005) Wound Healing En-hancement: Electroporation to Address a Classic Problem of Military Medicine. World Journal of Surgery, 29, S55-S59. [Google Scholar] [CrossRef] [PubMed]
[33] Di Rocco, G., Iachininoto, M.G., Tritarelli, A., et al. (2006) My-ogenic Potential of Adipose-Tissue-Derived Cells. Journal of Cell Science, 119, 2945-2952. [Google Scholar] [CrossRef] [PubMed]
[34] Pantelic, M.N. and Larkin, L.M. (2018) Stem Cells for Skeletal Muscle Tis-sue Engineering. Tissue Engineering Part B: Reviews, 24, 373-391. [Google Scholar] [CrossRef] [PubMed]
[35] Saha, B., Krishna, K.H., Borgohain, M.P., et al. (2018) Prospective Applications of Induced Pluripotent Stem Cells in Military Medicine. Medical Journal Armed Forces India, 74, 313-320. [Google Scholar] [CrossRef] [PubMed]
[36] Christopherson, G.T. and Nesti, L.J. (2011) Stem Cell Applica-tions in Military Medicine. Stem Cell Research & Therapy, 2, Article No. 40. [Google Scholar] [CrossRef] [PubMed]
[37] Yamanaka, S. (2020) Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges. Cell Stem Cell, 27, 523-531. [Google Scholar] [CrossRef] [PubMed]
[38] Liu, S.Y., Song, J.C., Mao, H.D., et al. (2020) Expert Consensus on the Diagnosis and Treatment of Heat Stroke in China. Military Medical Research, 7, Article No. 1. [Google Scholar] [CrossRef] [PubMed]
[39] Riemenschneider, K., Liu, J. and Powers, J.G. (2018) Skin Cancer in the Military: A Systematic Review of Melanoma and Nonmelanoma Skin Cancer Incidence, Prevention, and Screening among Active Duty and Veteran Personnel. Journal of the American Academy of Dermatology, 78, 1185-1192. [Google Scholar] [CrossRef] [PubMed]
[40] Zhang, R., Ran, H.H., Cai, L.L., et al. (2014) Simulated Micrograv-ity-Induced Mitochondrial Dysfunction in Rat Cerebral Arteries. FASEB Journal, 28, 2715-2724. [Google Scholar] [CrossRef] [PubMed]
[41] Zhang, R., Jiang, M., Zhang, J., et al. (2020) Regulation of the Cerebro-vascular Smooth Muscle Cell Phenotype by Mitochondrial Oxidative Injury and Endoplasmic Reticulum Stress in Simu-lated Microgravity Rats via the PERK-EIF- 2alpha-ATF4-CHOP Pathway. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1866, Article ID: 165799. [Google Scholar] [CrossRef] [PubMed]
[42] Yao, Y.M. and Zhang, H. (2019) Better Therapy for Combat Injury. Military Medical Research, 6, Article No. 23. [Google Scholar] [CrossRef] [PubMed]
[43] Greene, M. and Master, Z. (2018) Ethical Issues of Using CRISPR Technologies for Research on Military Enhancement. Journal of Bioethical Inquiry, 15, 327-335. [Google Scholar] [CrossRef] [PubMed]
[44] Gao, C. (2018) The Future of CRISPR Technologies in Agricul-ture. Nature Reviews Molecular Cell Biology, 19, 275-276. [Google Scholar] [CrossRef] [PubMed]
[45] Gracheva, E.O., Ingolia, N.T., Kelly, Y.M., et al. (2010) Molecular Basis of Infrared Detection by Snakes. Nature, 464, 1006-1011. [Google Scholar] [CrossRef] [PubMed]
[46] Betapudi, V., Goswami, R., Silayeva, L., et al. (2020) Gene Therapy De-livering a Paraoxonase 1 Variant Offers Long-Term Prophylactic Protection against Nerve Agents in Mice. Science Translational Medicine, 12, eaay0356. [Google Scholar] [CrossRef] [PubMed]
[47] Redmond, C., Pearce, M.J., Manchee, R.J., et al. (1998) Deadly Relic of the Great War. Nature, 393, 747-748. [Google Scholar] [CrossRef] [PubMed]