活血化瘀类中药在慢性荨麻疹中的应用及机制研究进展

Progress in the Application and Mechanism of TCM for Promoting Blood Circulation and Removing Blood Stasis in Chronic Urticaria

摘要: 慢性荨麻疹是皮肤科的常见病症，因皮肤、黏膜小血管反应性扩张以及通透性增加而产生的一种局限性水肿反应，西医认为慢性荨麻疹与皮肤肥大细胞活化并释放组胺和其他促炎递质有关；中医认为慢性荨麻疹属于“瘾疹”范畴，传统认为主要与风邪致病有关，然而随着研究的不断深入，部分现代学者认为“血瘀”也是导致慢性荨麻疹发病的重要病机之一，故提出在治疗中应采用活血化瘀法，并且在相关药理实验中发现活血化瘀类中药具有抑制炎症反应、改善血流动力学、改善微循环等作用。

Abstract: Chronic urticaria is a common disease in dermatology, it is a localized edema reaction caused by re-active dilation and increased permeability of small blood vessels of the skin and mucosa. Western medicine believes that chronic urticaria is related to the activation and release of histamine and other pro-inflammatory transmitters by mast cells of the skin; traditional Chinese medicine be-lieves that chronic urticaria belongs to the category of “addictive rashes”, which is mainly relevant to the pathogenesis of wind, however, with the deepening of research, some modern scholars be-lieve that “blood stasis” is also one of the important pathogenic mechanisms of chronic urticaria, so it is proposed that the method of activation of blood circulation and elimination of blood stasis should be used in the treatment. And in the relevant pharmacological experiments, it was found that the TCM of activating blood circulation and removing blood stasis had the effects of inhibiting inflammation, improving hemodynamics and improving microcirculation.