高甘油三酯血症性胰腺炎的研究进展

Research Progress of Hypertriglyceridemic Pancreatitis

摘要: 高甘油三酯血症(Hypertriglyceridemia, HTG)是急性胰腺炎(Acute Pancreatitis, AP)的一个不常见但已确定的原因之一，占7%。HTG诱发的胰腺炎(HTG-induced Pancreatitis, HTGP)的临床过程与其他病因的AP非常相似，但HTG是唯一的临床特征。然而，HTGP往往有较高的严重程度和并发症发生率。尽管胰岛素、肝素和omega-3脂肪酸等不同的治疗方式已成功地用于降低血清甘油三酯(Triglycerides, TG)，但目前尚无可供选择的治疗指南。血浆置换术也被用来抵消HTGP患者中升高的TG水平。在处理急性期后，改变生活方式包括饮食调整和药物治疗对HTGP的长期管理和预防复发至关重要。现有研究结果不足以得出坚实的结论，导致HTGP没有有效管理策略。因此，未来需要进一步前瞻性、随机对照的临床研究来寻找更好的治疗方案。

Abstract: HTG (Hypertriglyceridemia) is an uncommon but identified cause of AP (acute pancreatitis), ac-counting for 7%. The clinical process of HTGP (HTG-induced pancreatitis) is very similar to AP of other causes, but HTG is the only clinical feature. However, HTGP often has a high severity and inci-dence of complications. Although different treatments such as insulin, heparin and omega-3 fatty acids have been successfully used to reduce serum TG (triglycerides), there are no alternative treatment guidelines. Plasma exchange is also used to counteract elevated TG levels in patients with HTGP. After dealing with the acute phase, lifestyle changes, including diet adjustment and drug treatment, are essential for the long-term management and prevention of recurrence of HTGP. The existing research results are not enough to draw a solid conclusion, resulting in no effective man-agement strategy for HTGP. Therefore, further prospective, randomized controlled clinical studies are needed to find a better treatment in the future.