肛瘘临床研究进展
Progress in Clinical Research on Anal Fistula
DOI: 10.12677/ACM.2024.143756, PDF,   
作者: 沙娜·库拉别克, 路 明*:新疆医科大学第一附属医院消化血管中心肛肠外科,新疆 乌鲁木齐
关键词: 肛瘘检查治疗Anal Fistula Examination Treatment
摘要: 肛瘘是肛周直肠疾病中最常见的疾病之一。因其复杂性、复发性为临床上所重视研究。目前肛周瘘检查及治疗方法均有改进。本文以肛周瘘的疾病发展原因,术前检查操作以及治疗方式等方面进行现阶段的描述汇总进行系统综述,为肛瘘该疾病手术治疗提供参考意见。
Abstract: Anal fistula is one of the most common perianal and rectal diseases. Because of its complexity and recurrence, it has attracted clinical research attention. Current examination and treatment meth-ods for perianal fistulas have been improved. This article summarizes the current description of the causes of perianal fistula disease development, preoperative examination procedures, and treat-ment methods and conducts a systematic review to provide reference opinions for the surgical treatment of anal fistula.
文章引用:沙娜·库拉别克, 路明. 肛瘘临床研究进展[J]. 临床医学进展, 2024, 14(3): 676-685. https://doi.org/10.12677/ACM.2024.143756

参考文献

[1] Charalampopoulos, A., Papakonstantinou, D., Bagias, G., et al. (2023) Surgery of Simple and Complex Anal Fistulae in Adults: A Review of the Literature for Optimal Surgical Outcomes. Cureus, 15, e35888. [Google Scholar] [CrossRef] [PubMed]
[2] Kumar, L. and Emmanuel, A. (2017) Internal Anal Sphincter: Clinical Perspective. Surgeon, 15, 211-226. [Google Scholar] [CrossRef] [PubMed]
[3] Bazira, P.J. (2023) Anatomy of the Rectum and Anal Canal. Sur-gery, 41, 7-14. [Google Scholar] [CrossRef
[4] Kim, M. (2023) [Perianal Fistula: An Overview]. Journal of the Korean Society of Radiology, 84, 565-585. [Google Scholar] [CrossRef] [PubMed]
[5] Ren, J., Bai, W., Gu, L., et al. (2023) Three-Dimensional Pelvic Ultra-sound Is a Practical Tool for the Assessment of Anal Fistula. BMC Gastroenterology, 23, Article No. 134. [Google Scholar] [CrossRef] [PubMed]
[6] ALsannaa, F., Saleem, R.B. and ALowayyid, J. (2023) Rectum Perforation Secondary to Ingested Chicken Bone Presenting as Peri-Anal Abscess: A Case Report. Cureus, 15, e49673.
[7] Wang, J. and Hu, G. (2022) Nomogram to Predict Radiation Enteritis in Cervical Squamous Cell Carcino-ma. Cancer Management and Research, 14, 3303-3311. [Google Scholar] [CrossRef
[8] Whiteford, M.H. (2007) Perianal Abscess/Fistula Disease. Clinics in Colon and Rectal Surgery, 20, 102-109. [Google Scholar] [CrossRef] [PubMed]
[9] Kata, A. and Abelson, J.S. (2023) Anorectal Abscess. Clinics in Colon and Rectal Surgery. [Google Scholar] [CrossRef] [PubMed]
[10] Janicke, D.M. and Pundt, M.R. (1996) Anorectal Disorders. Emer-gency Medicine Clinics of North America, 14, 757-788. [Google Scholar] [CrossRef
[11] Mateescu, T., Fulger, L., Tummala, D., et al. (2023) Explor-ing Health-Related Quality of Life in Patients with Anal Fistulas: A Comprehensive Study. Life, 13, Article 2008. [Google Scholar] [CrossRef] [PubMed]
[12] Spencer, J.A., Chapple, K., Wilson, D., et al. (1998) Outcome after Sur-gery for Perianal Fistula: Predictive Value of MR Imaging. American Journal of Roentgenology, 171, 403-406. [Google Scholar] [CrossRef] [PubMed]
[13] Emile, S.H., Elfeki, H., El-Said, M., et al. (2021) Modification of Parks Classification of Cryptoglandular Anal Fistula. Diseases of the Colon & Rectum, 64, 446-458. [Google Scholar] [CrossRef
[14] Charalampopoulos, A., Bagias, G., Bompetsi, G., et al. (2022) Anal Fistula of Crypto-Glandular Etiology: A Review of the Literature with a Step-by-Step Approach for Diag-nosis and Surgical Management. International Journal of Innovative Research in Medical Science, 7, 515-521. [Google Scholar] [CrossRef
[15] Vogel, J.D., Johnson, E.K., Morris, A.M., et al. (2016) Clini-cal Practice Guideline for the Management of Anorectal Abscess, Fistula-in-Ano, and Rectovaginal Fistula. Diseases of the Colon & Rectum, 59, 1117-1133. [Google Scholar] [CrossRef
[16] Emile, S.H., Khafagy, W. and Elbaz, S.A. (2022) Impact of Number of Previous Surgeries on the Continence State and Healing after Repeat Surgery for Recurrent Anal Fistula. Journal of Visceral Surgery, 159, 206-211. [Google Scholar] [CrossRef] [PubMed]
[17] Mei, Z., Wang, Q., Zhang, Y., et al. (2019) Risk Factors for Recurrence after Anal Fistula Surgery: A Meta-Analysis. International Journal of Surgery, 69, 153-164. [Google Scholar] [CrossRef] [PubMed]
[18] Emile, S.H. (2020) Recurrent Anal Fistulas: When, Why, and How to Manage? World Journal of Clinical Cases, 8, 1586-1591. [Google Scholar] [CrossRef] [PubMed]
[19] Sugrue, J., Mantilla, N., Abcarian, A., et al. (2017) Sphincter-Sparing Anal Fistula Repair: Are We Getting Better? Diseases of the Colon & Rectum, 60, 1071-1077. [Google Scholar] [CrossRef
[20] Varsamis, N., Kos-midis, C., Chatzimavroudis, G., et al. (2023) Preoperative Assessment of Perianal Fistulas with Combined Magnetic Resonance and Tridimensional Endoanal Ultrasound: A Prospective Study. Diagnostics, 13, Article 2851. [Google Scholar] [CrossRef] [PubMed]
[21] Tantiphlachiva, K., Sahakitrungruang, C., Pattanaarun, J., et al. (2019) Effects of Preoperative Endoanal Ultrasound on Functional Outcome after Anal Fistula Surgery. BMJ Open Gas-troenterology, 6, e000279. [Google Scholar] [CrossRef] [PubMed]
[22] Thipphavong, S., Costa, A.F., Ali, H.A., et al. (2019) Struc-tured Reporting of MRI for Perianal Fistula. Abdominal Radiology, 44, 1295-1305. [Google Scholar] [CrossRef] [PubMed]
[23] Han, L., Chen, Y., Cheng, W., et al. (2021) Deep Learning-Based CT Image Characteristics and Postoperative Anal Function Restoration for Patients with Complex Anal Fistula. Journal of Healthcare Engineering, 2021, Article ID: 1730158. [Google Scholar] [CrossRef] [PubMed]
[24] Chang, Y.C., Tsai, P.H., Chou, Y.C., et al. (2021) Biomarkers Linked with Dynamic Changes of Renal Function in Asymptomatic and Mildly Symptomatic COVID-19 Patients. Journal of Personalized Medicine, 11, Article 432. [Google Scholar] [CrossRef] [PubMed]
[25] Kim, H., Lee, D.I., Moon, S.K., et al. (2023) Typical MR Features and Interpretation of Perianal Fistulas in Patients with Crohn’s Disease. European Journal of Radiology, 167, Article ID: 111046. [Google Scholar] [CrossRef] [PubMed]
[26] Akhoundi, N., Bozchelouei, J.K., Abrishami, A., et al. (2023) Comparison of MRI and Endoanal Ultrasound in Assessing Intersphincteric, Transsphincteric, and Suprasphincteric Per-ianal Fistula. Journal of Ultrasound in Medicine, 42, 2057-2064. [Google Scholar] [CrossRef] [PubMed]
[27] Hamada, L.A.E., Dawoud, M.M., Abdallah, H.S. and Hefeda, M.M. (2022) Recent Advances of Magnetic Resonance Imaging in Evaluation of Recurrent Perianal Fistula. Journal of Advances in Medicine and Medical Research, 34, 49-62. [Google Scholar] [CrossRef
[28] Waidyasekera, R.H., Jayarajah, U. and Samarasekera, D.N. (2020) The Role of Routine Flexible Sigmoidoscopy in Patients Presenting with Fistula-in-Ano: An Observational Study. BMC Research Notes, 13, Article No 214. [Google Scholar] [CrossRef] [PubMed]
[29] Xu, S., Zhang, L., Li, Z., et al. (2023) Enhancing Surgical Preci-sion: Unveiling the Impact of Preoperative Colonoscopy in Anal Fistula Patients. BMC Gastroenterology, 23, Article No. 442. [Google Scholar] [CrossRef] [PubMed]
[30] Sugrue, J., Nordenstam, J., Abcarian, H., et al. (2017) Pathogenesis and Persistence of Cryptoglandular Anal Fistula: A Systematic Review. Techniques in Coloproctology, 21, 425-432. [Google Scholar] [CrossRef] [PubMed]
[31] Amato, A., Bottini, C., De Nardi, P., et al. (2020) Eval-uation and Management of Perianal Abscess and Anal Fistula: SICCR Position Statement. Techniques in Coloproctology, 24, 127-143. [Google Scholar] [CrossRef] [PubMed]
[32] Turner, G, A., Tham, N., Chandra, R., et al. (2023) Management of Acute Perianal Abscess: Is Surgeon Specialization Associated with Improved Outcomes? ANZ Journal of Surgery. [Google Scholar] [CrossRef] [PubMed]
[33] Ommer, A., Herold, A., Berg, E., et al. (2011) Cryptoglandular Anal Fistulas. Deutsches Ärzteblatt International, 108, 707-713. [Google Scholar] [CrossRef] [PubMed]
[34] Garcia-Aguilar, J., Belmonte, C., Wong, W, D., et al. (1996) Anal Fistula Surgery. Factors Associated with Recurrence and Incontinence. Diseases of the Colon & Rectum, 39, 723-729. [Google Scholar] [CrossRef
[35] De Hous, N., Van Den Broeck, T. and De Gheldere, C. (2021) Fistulec-tomy and Primary Sphincteroplasty (FIPS) to Prevent Keyhole Deformity in Simple Anal Fistula: A Single-Center Ret-rospective Cohort Study. Acta Chirurgica Belgica, 121, 308-313. [Google Scholar] [CrossRef] [PubMed]
[36] Fritz, S., Reissfelder, C. and Bussen, D. (2023) Current Therapy of Cryptoglandular Anal Fistula: Gold Standards and Alternative Methods. Zentralblatt für Chirurgie, 148, 209-219. [Google Scholar] [CrossRef] [PubMed]
[37] Cadeddu, F., Salis, F., Lisi, G., et al. (2015) Complex Anal Fistula Remains a Challenge for Colorectal Surgeon. International Journal of Colorectal Disease, 30, 595-603. [Google Scholar] [CrossRef] [PubMed]
[38] Huang, H., Ji, L., Gu, Y., et al. (2022) Efficacy and Safety of Sphincter-Preserving Surgery in the Treatment of Complex Anal Fistula: A Network Meta-Analysis. Frontiers in Sur-gery, 9, Article 825166. [Google Scholar] [CrossRef] [PubMed]
[39] Ji, L., Zhang, Y., Xu, L., et al. (2020) Advances in the Treatment of Anal Fistula: A Mini-Review of Recent Five-Year Clinical Studies. Frontiers in Surgery, 7, Article 586891. [Google Scholar] [CrossRef] [PubMed]
[40] Rojanasakul, A., Booning, N., Huimin, L., et al. (2021) In-tersphincteric Exploration with Ligation of Intersphincteric Fistula Tract or Attempted Closure of Internal Opening for Acute Anorectal Abscesses. Diseases of the Colon & Rectum, 64, 438-445. [Google Scholar] [CrossRef
[41] Malakorn, S., Sammour, T., Khomvilai, S., et al. (2017) Li-gation of Intersphincteric Fistula Tract for Fistula in Ano: Lessons Learned From A Decade of Experience. Diseases of the Colon & Rectum, 60, 1065-1070. [Google Scholar] [CrossRef
[42] Anaraki, F., Nikshoar, M.R., Ketabforoush, A., et al. (2023) Fistulectomy and Primary Sphincteroplasty in Complex Anal Fistula Treatment: A Hospital-Based Long-Term Fol-low-Up Study. Techniques in Coloproctology, 27, 145-152. [Google Scholar] [CrossRef] [PubMed]
[43] Omar, W., Alqasaby, A., Abdelnaby, M., et al. (2019) Drainage Seton versus External Anal Sphincter-Sparing Seton after Rerouting of the Fistula Tract in the Treatment of Complex Anal Fistula: A Randomized Controlled Trial. Diseases of the Colon & Rectum, 62, 980-987. [Google Scholar] [CrossRef
[44] Yu, Q., Zhi, C., Jia, L., et al. (2022) Cutting Seton versus Decompression and Drainage Seton in the Treatment of High Complex Anal Fistula: A Randomized Controlled Trial. Scientific Reports, 12, Article No. 7838. [Google Scholar] [CrossRef] [PubMed]
[45] An, Y., Chen, X., Tian, M., et al. (2023) Comparison of Clinical Outcomes of Anal Fistula Plug and Endoanal Advancement Flap Repair Treating the Complex Anal Fistula: A Systematic Review and Meta-Analysis. Updates in Surgery, 75, 2103-2115. [Google Scholar] [CrossRef] [PubMed]
[46] Vidon, M., Munoz-Bongrand, N., Lambert, J., et al. (2021) Long-Term Efficacy of Fibrin Glue Injection for Perianal Fistulas in Patients with Crohn’s Disease. Colorectal Disease, 23, 894-900. [Google Scholar] [CrossRef] [PubMed]
[47] Giarratano, G., Shalaby, M., Toscana, C., et al. (2020) Vid-eo-Assisted Anal Fistula Treatment for Complex Anal Fistula: A Long-Term Follow-Up Study. Colorectal Disease, 22, 939-944. [Google Scholar] [CrossRef] [PubMed]
[48] La Torre, M., La Greca, G., Fiori, E., et al. (2023) A Pilot Study on Staged Surgery by Delta Video-Assisted Anal Fistula Treatment (DVAAFT) for Complex Anal Fistula. Updates in Surgery, 75, 1867-1871. [Google Scholar] [CrossRef] [PubMed]
[49] Reza, L., Gottgens, K., Kleijnen, J., et al. (2023) European Soci-ety of Coloproctology: Guidelines for Diagnosis and Treatment of Cryptoglandular Anal Fistula. Colorectal Disease, 26, 145-196. [Google Scholar] [CrossRef] [PubMed]
[50] Arroyo, A., Sánchez-Guillén, L., Parra, P.A., et al. (2020) Pho-todynamic Therapy for the Treatment of Complex Anal Fistula. Lasers in Surgery and Medicine, 52, 503-508. [Google Scholar] [CrossRef] [PubMed]
[51] Tümer, H. and Bulbuloglu, G.C. (2023) A Comparison of Laser and Fistu-lotomy Techniques in the Treatment of Fistula-in-Ano. Cureus, 15, e37053. [Google Scholar] [CrossRef] [PubMed]
[52] Sutton, M.T., Fletcher, D., Ghosh, S.K., et al. (2016) Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment. Stem Cells In-ternational, 2016, Article ID: 5303048. [Google Scholar] [CrossRef] [PubMed]
[53] Alcayaga-Miranda, F., Cuenca, J. and Khoury, M. (2017) Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies. Frontiers in Immunology, 8, Article 339. [Google Scholar] [CrossRef] [PubMed]
[54] Krasnodembskaya, A., Song, Y., Fang, X., et al. (2010) Antibacte-rial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37. Stem Cells, 28, 2229-2238. [Google Scholar] [CrossRef] [PubMed]
[55] Chow, L., Johnson, V., Impastato, R., et al. (2020) Antibacterial Activity of Human Mesenchymal Stem Cells Mediated Directly by Constitutively Secreted Factors and Indirectly by Activation of Innate Immune Effector Cells. Stem Cells Translational Medicine, 9, 235-249. [Google Scholar] [CrossRef] [PubMed]
[56] Sheikholeslami, A., Fazaeli, H., Kalhor, N., et al. (2023) Use of Mes-enchymal Stem Cells in Crohn’s Disease and Perianal Fistulas: A Narrative Review. Current Stem Cell Research & Therapy, 18, 76-92. [Google Scholar] [CrossRef