脑性瘫痪的骨代谢生化指标研究进展
Research Progress on Biochemical Indicators of Bone Metabolism in Cerebral Palsy
DOI: 10.12677/ACM.2024.143785, PDF,   
作者: 管 琪, 吴俊杰:新疆医科大学第二附属医院神经外科脑瘫中心,新疆 乌鲁木齐
关键词: 脑性瘫痪骨代谢生化指标Cerebral Palsy Bone Metabolism Biochemical Indicators
摘要: 脑性瘫痪(cerebral palsy, CP)被定义为是一组持续存在的中枢性运动和姿势发育障碍、活动受限症候群,这种症候群是由于发育中的胎儿或婴幼儿脑部非进行性损伤所致。CP的活动受限会引起继发性肌肉萎缩和骨骼损害,骨代谢的生化标记物可以实时地评估骨骼损害的进展,为评估CP的治疗效果及预后提供理论依据。本文对CP的骨代谢生化指标研究进展作一综述,阐述各骨代谢生化指标的意义及CP骨代谢生化指标的特点,为CP的骨骼研究提供参考。
Abstract: Cerebral palsy (CP) is defined as a persistent central motor and postural developmental disorder, limited mobility syndrome, caused by non progressive brain damage in developing fetuses or in-fants. The limited activity of CP can cause secondary muscle atrophy and bone damage. Biochemical markers of bone metabolism can evaluate the progression of bone damage in real time, providing a theoretical basis for evaluating the therapeutic effect and prognosis of CP. This article provides a review of the research progress on CP bone metabolism biochemical indicators, explaining the sig-nificance of each bone metabolism biochemical indicator and the characteristics of CP bone metabo-lism biochemical indicators, providing reference for CP bone research.
文章引用:管琪, 吴俊杰. 脑性瘫痪的骨代谢生化指标研究进展[J]. 临床医学进展, 2024, 14(3): 877-883. https://doi.org/10.12677/ACM.2024.143785

参考文献

[1] 唐久来, 秦炯, 邹丽萍, 等. 中国脑性瘫痪康复指南(2015): 第一部分[J]. 中国康复医学杂志, 2015, 30(7): 747-754.
[2] 李晓捷, 唐久来, 马丙祥, 等. 脑性瘫痪的定义、诊断标准及临床分型[J]. 中华实用儿科临床杂志, 2014, 29(19): 1520.
[3] Tosun, A., Erisen Karaca, S., Unuvar, T., Yurekli, Y., Yenisey, C. and Omurlu, I.K. (2017) Bone Mineral Density and Vitamin D Status in Children with Epilepsy, Cerebral Palsy, and Cerebral Palsy with Epilepsy. Child’s Nervous System, 33, 153-158. [Google Scholar] [CrossRef] [PubMed]
[4] Henderson, R.C., Lark, R.K., Gurka, M.J., Worley, G., Fung, E.B., Conaway, M., Stallings, V.A. and Stevenson, R.D. (2002) Bone Density and Metabolism in Children and Adolescents with Moderate to Severe Cerebral Palsy. Pediatrics, 110, e5. [Google Scholar] [CrossRef] [PubMed]
[5] Mergler, S., Evenhuis, H.M., Boot, A.M., De Man, S.A., Bindels-De Heus, K.G., Huijbers, W.A. and Penning, C. (2009) Epidemiology of Low Bone Mineral Density and Fractures in Chil-dren with Severe Cerebral Palsy: A Systematic Review. Developmental Medicine and Child Neurology, 51, 773-778. [Google Scholar] [CrossRef] [PubMed]
[6] Reid, S.M., Carlin, J.B. and Reddihough, D.S. (2011) Us-ing the Gross Motor Function Classification System to Describe Patterns of Motor Severity in Cerebral Palsy. Develop-mental Medicine and Child Neurology, 53, 1007-1012. [Google Scholar] [CrossRef] [PubMed]
[7] Hlaing, T.T. and Compston, J.E. (2014) Biochemical Markers of Bone Turnover—Uses and Limitations. Annals of Clinical Biochemistry, 51, 189-202. [Google Scholar] [CrossRef] [PubMed]
[8] Christenson, R.H. (1997) Biochemical Markers of Bone Metabo-lism: An Overview. Clinical Biochemistry, 30, 573-593. [Google Scholar] [CrossRef
[9] Salhotra, A., Shah, H.N., Levi, B. and Longaker, M.T. (2020) Mechanisms of Bone Development and Repair. Nature Reviews Molecular Cell Biology, 21, 696-711. [Google Scholar] [CrossRef] [PubMed]
[10] Hill, P.A. (1998) Bone Remodelling. British Journal of Ortho-dontics, 25, 101-107. [Google Scholar] [CrossRef] [PubMed]
[11] Banfi, G., Lombardi, G., Colombini, A. and Lippi, G. (2010) Bone Metabolism Markers in Sports Medicine. Sports Medicine, 40, 697-714. [Google Scholar] [CrossRef] [PubMed]
[12] Woitge, H.W., Seibel, M.J. and Ziegler, R. (1996) Comparison of Total and Bone-Specific Alkaline Phosphatase in Patients with Nonskeletal Disorder or Metabolic Bone Diseases. Clinical Chemistry, 42, 1796-1804. [Google Scholar] [CrossRef
[13] Bjarnason, N.H. and Christiansen, C. (2000) Early Response in Biochemical Markers Predicts Long-Term Response in Bone Mass during Hormone Replacement Therapy in Early Postmenopausal Women. Bone, 26, 561-569. [Google Scholar] [CrossRef
[14] Ryder, K.M., Tanner, S.B., Carbone, L., Williams, J.E., Taylor, H.M., Bush, A., Pintea, V. and Watsky, M.A. (2010) Teriparatide Is Safe and Effectively Increases Bone Bi-omarkers in Institutionalized Individuals with Osteoporosis. Journal of Bone and Mineral Metabolism, 28, 233-239. [Google Scholar] [CrossRef] [PubMed]
[15] Takahashi, M., Naitou, K., Ohishi, T., Kushida, K. and Miura, M. (2001) Effect of Vitamin K and/or D on Undercarboxylated and Intact Osteocalcin in Osteoporotic Patients with Vertebral or Hip Fractures. Clinical Endocrinology, 54, 219-224. [Google Scholar] [CrossRef] [PubMed]
[16] Power, M.J. and Fottrell, P.F. (1991) Osteocalcin: Diag-nostic Methods and Clinical Applications. Critical Reviews in Clinical Laboratory Sciences, 28, 287-335. [Google Scholar] [CrossRef] [PubMed]
[17] Lee, A.J., Hodges, S. and Eastell, R. (2000) Measurement of Osteocalcin. Annals of Clinical Biochemistry, 37, 432-446. [Google Scholar] [CrossRef] [PubMed]
[18] Garnero, P., Cloos, P., Sornay-Rendu, E., Qvist, P. and Del-mas, P.D. (2002) Type I Collagen Racemization and Isomerization and the Risk of Fracture in Postmenopausal Women: The OFELY Prospective Study. Journal of Bone and Mineral Research, 17, 826-833. [Google Scholar] [CrossRef] [PubMed]
[19] Christgau, S. (2000) Circadian Variation in Serum CrossLaps Concentration Is Reduced in Fasting Individuals. Clinical Chemistry, 46, 431. [Google Scholar] [CrossRef
[20] Swaminathan, R. (2001) Biochemical Markers of Bone Turnover. Clinica Chimica Acta, 313, 95-105. [Google Scholar] [CrossRef
[21] Delmas, P.D., Eastell, R., Garnero, P., Seibel, M.J., Stepan, J. and Committee of Scientific Advisors of the International Osteoporosis Foundation (2000) The Use of Biochemical Markers of Bone Turnover in Osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Founda-tion. Osteoporosis International, 11, S2-S17. [Google Scholar] [CrossRef] [PubMed]
[22] Nenonen, A., Cheng, S., Ivaska, K.K., Alatalo, S.L., Lehtimäki, T., Schmidt-Gayk, H., Uusi-Rasi, K., Heinonen, A., Kannus, P., Sievänen, H., Vuori, I., Väänänen, H.K. and Halleen, J.M. (2005) Serum TRACP 5b Is a Useful Marker for Monitoring Alendronate Treatment: Comparison with Other Markers of Bone Turnover. Journal of Bone and Mineral Research, 20, 1804-1812. [Google Scholar] [CrossRef
[23] Halleen, J.M., Alatalo, S.L., Suominen, H., Cheng, S., Janckila, A.J. and Väänänen, H.K. (2000) Tartrate-Resistant Acid Phosphatase 5b: A Novel Serum Marker of Bone Resorption. Jour-nal of Bone and Mineral Research, 15, 1337-1345. [Google Scholar] [CrossRef] [PubMed]
[24] Bayer, M. (2014) Reference Values of Osteocalcin and Procollagen Type I N-Propeptide Plasma Levels in a Healthy Central Euro-pean Population Aged 0-18 Years. Osteoporosis International, 25, 729-736. [Google Scholar] [CrossRef] [PubMed]
[25] Xing, W., Liang, L., Dong, N., Chen, L. and Liu, Z. (2023) Ab-normal Changes of Bone Metabolism Markers with Age in Children with Cerebral Palsy. Frontiers in Pediatrics, 11, Ar-ticle 1214608. [Google Scholar] [CrossRef] [PubMed]
[26] Modlesky, C.M. and Zhang, C. (2020) Complicated Muscle-Bone Interactions in Children with Cerebral Palsy. Current Osteoporosis Reports, 18, 47-56. [Google Scholar] [CrossRef] [PubMed]
[27] Whitney, D.G., Singh, H., Miller, F., Barbe, M.F., Slade, J.M., Pohlig, R.T. and Modlesky, C.M. (2017) Cortical Bone Deficit and Fat Infiltration of Bone Marrow and Skeletal Muscle in Ambulatory Children with Mild Spastic Cerebral Palsy. Bone, 94, 90-97. [Google Scholar] [CrossRef] [PubMed]
[28] Modlesky, C.M., Subramanian, P. and Miller, F. (2008) Underde-veloped Trabecular Bone Microarchitecture Is Detected in Children with Cerebral Palsy Using High-Resolution Magnetic Resonance Imaging. Osteoporosis International, 19, 169-176. [Google Scholar] [CrossRef] [PubMed]
[29] Modlesky, C.M., Whitney, D.G., Singh, H., Barbe, M.F., Kirby, J.T. and Miller, F. (2015) Underdevelopment of Trabecular Bone Microarchitecture in the Distal Femur of Nonambula-tory Children with Cerebral Palsy Becomes More Pronounced with Distance from the Growth Plate. Osteoporosis In-ternational, 26, 505-512. [Google Scholar] [CrossRef] [PubMed]
[30] Martínez De Zabarte Fernández, J.M., Ros Arnal, I., Peña Segura, J.L., García Romero, R. and Rodríguez Martínez, G. (2020) Bone Health Impairment in Patients with Cerebral Palsy. Archives of Osteoporosis, 15, Article No. 91. [Google Scholar] [CrossRef] [PubMed]
[31] Wang, H., Tian, L., Liu, J., Goldstein, A., Bado, I., Zhang, W., Arenkiel, B.R., Li, Z., Yang, M., Du, S., Zhao, H., Rowley, D.R., Wong, S.T.C., Gugala, Z. and Zhang, X.H. (2018) The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerabil-ity. Cancer Cell, 34, 823-839.E7. [Google Scholar] [CrossRef] [PubMed]
[32] Wang, Y., Malcolm, D.W. and Benoit, D.S.W. (2017) Controlled and Sustained Delivery of SiRNA/NPs from Hydrogels Expedites Bone Fracture Healing. Biomaterials, 139, 127-138. [Google Scholar] [CrossRef] [PubMed]
[33] Khandelwal, R., Manjunath, V.V., Mehta, L. and Man-gajjera, S.B. (2023) Hematological and Biochemical Profiles in Children with Cerebral Palsy: A Cross-Sectional Study. Journal of Pediatric Rehabilitation Medicine, 16, 171-177. [Google Scholar] [CrossRef
[34] 刘建军, 纪树荣, 贾淑芬, 等. 脑瘫患儿的碱性磷酸酶分析[J]. 中国康复理论与实践, 2002, 8(3): 183.
[35] 陈秀洁, 李晓捷, 柴国禄, 等. 脑瘫患儿的钙磷代谢及其调节因素的研究[J]. 中华物理医学与康复杂志, 2003, 25(2): 76-79.
[36] Weivoda, M.M., Chew, C.K., Monroe, D.G., Farr, J.N., Atkinson, E.J., Geske, J.R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A.J., McCready, L.K., Rizza, R.A., Matveyenko, A., Kassem, M., Andersen, T.L., Vella, A., Drake, M.T., Clarke, B.L., Oursler, M.J. and Khosla, S. (2020) Identification of Osteoclast-Osteoblast Coupling Factors in Humans Reveals Links between Bone and Energy Metabolism. Nature Communications, 11, Article No. 87. [Google Scholar] [CrossRef] [PubMed]
[37] Lu, J.X., Pan, H., Hu, X.Q., Huang, Z.W. and Zhang, Q. (2019) Effects of Milk Powder Intervention on Bone Mineral Density and Indicators Related to Bone Metabolism in Chinese Adolescents. Osteoporosis International, 30, 2231-2239. [Google Scholar] [CrossRef] [PubMed]
[38] Faienza, M.F., Chiarito, M., Brunetti, G. and D’Amato, G. (2021) Growth Plate Gene Involment and Isolated Short Stature. Endocrine, 71, 28-34. [Google Scholar] [CrossRef] [PubMed]
[39] Willerslev-Olsen, M., Petersen, T.H., Farmer, S.F. and Nielsen, J.B. (2015) Gait Training Facilitates Central Drive to Ankle Dorsiflexors in Children with Cerebral Palsy. Brain, 138, 589-603. [Google Scholar] [CrossRef] [PubMed]
[40] Akhter, N., Khan, A.A. and Ayyub, A. (2017) Motor Impair-ment and Skeletal Mineralization in Children with Cerebral Palsy. The Journal of the Pakistan Medical Association, 67, 200-203.