纳豆激酶及其药理学研究进展
Research Progress in Nattokinase and Its Pharmacology
DOI: 10.12677/OJNS.2024.122034, PDF,    科研立项经费支持
作者: 王恒毅, 王 洁, 刘青青, 李 洋, 张伟强, 王明煜, 吕佳威, 刘宏生*：辽宁大学药学院，辽宁 沈阳
关键词: 纳豆激酶；溶栓；药理作用；研究进展；Nattokinase； Thrombolysis； Pharmacology； Research Progress
摘要: 纳豆激酶是一种源自日本传统发酵食品纳豆的丝氨酸蛋白酶，具有多种生物学活性和药理作用。因其具有强大的溶解血栓的能力，受到广大研究者的关注，有望成为新一代溶栓药物。本文首先介绍了纳豆激酶的来源、提取方法和生物学活性，包括其对特定蛋白质的分解能力和在生物体内发挥的溶栓作用。接着，文章详细讨论了纳豆激酶的多种药理作用，包括其在溶栓、抗炎、神经保护、抗动脉粥样硬化以及改善视网膜健康等方面的潜在应用。此外，文章还展望了纳豆激酶未来的研究方向，强调了继续探索和优化提取纯化方法的重要性，并指出深入了解其分子作用机制对于开发更有效的治疗策略至关重要。
Abstract: Nattokinase is a serine protease derived from natto, a traditional fermented food in Japan, which has a variety of biological activities and pharmacological effects. Because of its strong ability to dissolve thrombus, it has attracted the attention of researchers and is expected to become a new generation of thrombolytic drugs. This paper first introduces the source, extraction method and biological activity of nattokinase, including its ability to decompose specific proteins and thrombolytic effect in vivo. Then, the article discussed in detail the various pharmacological effects of nattokinase, including its potential applications in thrombolysis, anti-inflammatory, neuroprotection, anti atherosclerosis and improving retinal health. In addition, the future research directions of nattokinase were also prospected, the importance of continuous exploration and optimization of extraction and purification methods was emphasized, and it was pointed out that in-depth understanding of its molecular mechanism of action was essential to develop more effective therapeutic strategies.
文章引用：王恒毅, 王洁, 刘青青, 李洋, 张伟强, 王明煜, 吕佳威, 刘宏生. 纳豆激酶及其药理学研究进展[J]. 自然科学, 2024, 12(2): 294-299. https://doi.org/10.12677/OJNS.2024.122034

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