生长因子在口腔种植中的应用
Application of Growth Factors in Oral Implantology
DOI: 10.12677/ACM.2024.143801, PDF,   
作者: 王宗耀, 刘雁鸣*：浙江大学医学院附属第二医院口腔外科，浙江 杭州
关键词: 生长因子；口腔种植；骨结合；Growth Factors； Oral Implantology； Osseointegration
摘要: 口腔种植术是指通过植入人工种植体来替代缺失的牙齿，以恢复牙列的功能与美观。种植成功的关键在于种植体与周围组织相互作用的复杂过程，包括炎症、血管形成、骨结合、软组织愈合等等。近年来，生长因子作为一类能够调控细胞增殖、分化和组织修复的蛋白质，在口腔种植领域受到了广泛的关注。本文就对生长因子在口腔种植中的应用做一综述，探讨其种类、作用机制、具体应用以及发展方向等多方面内容。
Abstract: Oral implantology, a sophisticated field dedicated to the restoration of missing teeth through the integration of artificial implants, plays a pivotal role in reinstating both the functional and aesthetic aspects of the dentition. The intricate success of implantation hinges upon the nuanced interactions occurring between the implant and the surrounding tissues. These interactions encompass multi-faceted processes, such as inflammation, vascularization, bone bonding, and soft tissue healing, among others. In recent years, growth factors, recognized as proteins capable of orchestrating cel-lular proliferation, differentiation, and tissue repair, have garnered substantial attention within the realm of oral implantology. This paper presents a comprehensive review of the application of growth factors in oral implantology, delving into their diverse species, intricate mechanisms of ac-tion, specific applications, and the unfolding trajectory of their development.
文章引用：王宗耀, 刘雁鸣. 生长因子在口腔种植中的应用[J]. 临床医学进展, 2024, 14(3): 997-1005. https://doi.org/10.12677/ACM.2024.143801

参考文献

[1] Zhao, R., Yang, R., Cooper, P.R., et al. (2021) Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules, 26, Article No. 3007. [Google Scholar] [CrossRef] [PubMed]
[2] Oliveira, E.R., Nie, L., Podstawczyk, D., et al. (2021) Advances in Growth Factor Delivery for Bone Tissue Engineering. Interna-tional Journal of Molecular Sciences, 22, Article No. 903. [Google Scholar] [CrossRef] [PubMed]
[3] Pansani, T.N., Basso, F.G., Souza, I., et al. (2019) Characterization of Titanium Surface Coated with Epidermal Growth Factor and Its Effect on Human Gingival Fibroblasts. Archives of Oral Biology, 102, 48-54. [Google Scholar] [CrossRef] [PubMed]
[4] Nagayasu-Tanaka, T., Nozaki, T., Miki, K., et al. (2017) FGF-2 Promotes Initial Osseointegration and Enhances Stability of Implants with Low Primary Stability. Clinical Oral Implants Research, 28, 291-297. [Google Scholar] [CrossRef] [PubMed]
[5] Agrawal, V. and Sinha, M. (2017) A Review on Carrier Systems for Bone Morphogenetic Protein-2. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105, 904-925. [Google Scholar] [CrossRef] [PubMed]
[6] Nevins, M., Giannobile, W.V., McGuire, M.K., et al. (2005) Plate-let-Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Ran-domized Controlled Trial. Journal of Periodontology, 76, 2205-2215. [Google Scholar] [CrossRef] [PubMed]
[7] Hankenson, K.D., Gagne, K. and Shaughnessy, M. (2015) Ex-tracellular Signaling Molecules to Promote Fracture Healing and Bone Regeneration. Advanced Drug Delivery Reviews, 94, 3-12. [Google Scholar] [CrossRef] [PubMed]
[8] Alsousou, J., Ali, A., Willett, K., et al. (2013) The Role of Platelet-Rich Plasma in Tissue Regeneration. Platelets, 24, 173-182. [Google Scholar] [CrossRef] [PubMed]
[9] Lange, K., Herold, M., Scheideler, L., et al. (2004) Investiga-tion of Initial Pellicle Formation on Modified Titanium Dioxide (TiO2) Surfaces by Reflectometric Interference Spectros-copy (RIfS) in a Model System. Dental Materials, 20, 814-822. [Google Scholar] [CrossRef] [PubMed]
[10] Schoichet, J.J., Mourao, C., Fonseca, E.M., et al. (2021) Epider-mal Growth Factor Is Associated with Loss of Mucosae Sealing and Peri-Implant Mucositis: A Pilot Study. Healthcare (Basel), 9, Article No. 1277. [Google Scholar] [CrossRef] [PubMed]
[11] Turner, N. and Grose, R. (2010) Fibroblast Growth Factor Signal-ling: From Development to Cancer. Nature Reviews Cancer, 10, 116-129. [Google Scholar] [CrossRef] [PubMed]
[12] Majidinia, M., Sadeghpour, A. and Yousefi, B. (2018) The Roles of Signaling Pathways in Bone Repair and Regeneration. Journal of Cellular Physiology, 233, 2937-2948. [Google Scholar] [CrossRef] [PubMed]
[13] Tonnesen, M.G., Feng, X. and Clark, R.A. (2000) Angiogenesis in Wound Healing. Journal of Investigative Dermatology Symposium Proceedings, 5, 40-46. [Google Scholar] [CrossRef] [PubMed]
[14] Luo, Y., Ye, S., Chen, X., et al. (2017) Rush to the Fire: FGF21 Extinguishes Metabolic Stress, Metaflammation and Tissue Damage. Cytokine & Growth Factor Reviews, 38, 59-65. [Google Scholar] [CrossRef] [PubMed]
[15] Cecerska-Heryc, E., Goszka, M., Serwin, N., et al. (2022) Applications of the Regenerative Capacity of Platelets in Modern Medicine. Cytokine & Growth Factor Reviews, 64, 84-94. [Google Scholar] [CrossRef] [PubMed]
[16] Ronnstrand, L. and Heldin, C.H. (2001) Mechanisms of Platelet-Derived Growth Factor-Induced Chemotaxis. International Journal of Cancer, 91, 757-762. [Google Scholar] [CrossRef] 
[17] Caplan, A.I. and Correa, D. (2011) PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research, 29, 1795-1803. [Google Scholar] [CrossRef] [PubMed]
[18] Margolis, D.J., Bartus, C., Hoff-stad, O., et al. (2005) Effectiveness of Recombinant Human Platelet-Derived Growth Factor for the Treatment of Diabetic Neuropathic Foot Ulcers. Wound Repair and Regeneration, 13, 531-536. [Google Scholar] [CrossRef] 
[19] Andrae, J., Gallini, R. and Betsholtz, C. (2008) Role of Platelet-Derived Growth Factors in Physiology and Medicine. Genes & Development, 22, 1276-1312. [Google Scholar] [CrossRef] [PubMed]
[20] Kaigler, D., Avila, G., Wisner-Lynch, L., et al. (2011) Platelet-Derived Growth Factor Applications in Periodontal and Peri-Implant Bone Regeneration. Expert Opinion on Biological Therapy, 11, 375-385. [Google Scholar] [CrossRef] [PubMed]
[21] Gillman, C.E. and Jayasuriya, A.C. (2021) FDA-Approved Bone Grafts and Bone Graft Substitute Devices in Bone Regeneration. Materials Science & Engineering C-Materials for Biological Applications, 130, Article ID: 112466. [Google Scholar] [CrossRef] [PubMed]
[22] Kowalczewski, C.J. and Saul, J.M. (2018) Biomaterials for the Delivery of Growth Factors and Other Therapeutic Agents in Tissue Engineering Approaches to Bone Regeneration. Frontiers in Pharmacology, 9, Article No. 513. [Google Scholar] [CrossRef] [PubMed]
[23] Spagnoli, D.B. and Marx, R.E. (2011) Dental Implants and the Use of RhBMP-2. Dental Clinics of North America, 55, 883-907. [Google Scholar] [CrossRef] [PubMed]
[24] Kim, R.Y., Oh, J.H., Lee, B.S., et al. (2014) The Effect of Dose on RhBMP-2 Signaling, Delivered via Collagen Sponge, on Osteoclast Activation and in Vivo Bone Resorption. Biomaterials, 35, 1869-1881. [Google Scholar] [CrossRef] [PubMed]
[25] Yang, Y.Q., Tan, Y.Y., Wong, R., et al. (2012) The Role of Vascular Endothelial Growth Factor in Ossification. International Journal of Oral Science, 4, 64-68. [Google Scholar] [CrossRef] [PubMed]
[26] Masuki, H., Okudera, T., Watanebe, T., et al. (2016) Growth Factor and Pro-Inflammatory Cytokine Contents in Platelet-Rich Plasma (PRP), Plasma Rich in Growth Factors (PRGF), Advanced Platelet-Rich Fibrin (A-PRF), and Concentrated Growth Factors (CGF). International Journal of Implant Dentistry, 2, Article No. 19. [Google Scholar] [CrossRef] [PubMed]
[27] Solakoglu, O., Heydecke, G., Amiri, N., et al. (2020) The Use of Plasma Rich in Growth Factors (PRGF) in Guided Tissue Regeneration and Guided Bone Regeneration. A Review of Histological, Immunohistochemical, Histomorphometrical, Radiological and Clinical Results in Humans. Annals of Anatomy, 231, Article ID: 151528. [Google Scholar] [CrossRef] [PubMed]
[28] Anitua, E., Orive, G., Pla, R., et al. (2009) The Effects of PRGF on Bone Regeneration and on Titanium Implant Osseointegration in Goats: A Histologic and Histomorphometric Study. Journal of Biomedical Materials Research Part A, 91, 158-165. [Google Scholar] [CrossRef] [PubMed]
[29] Zavan, B., Ferroni, L., Gardin, C., et al. (2017) Release of VEGF from Dental Implant Improves Osteogenetic Process: Preliminary in Vitro Tests. Materials (Basel), 10, Article No. 1052. [Google Scholar] [CrossRef] [PubMed]
[30] Park, S.Y., Kim, K.H., Kim, S., et al. (2019) BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry. Pharmaceutics, 11, Article No. 393. [Google Scholar] [CrossRef] [PubMed]
[31] Larsson, L., Decker, A.M., Nibali, L., et al. (2016) Regenerative Medicine for Periodontal and Peri-Implant Diseases. Journal of Dental Research, 95, 255-266. [Google Scholar] [CrossRef] [PubMed]
[32] Inchingolo, A.M., Malcangi, G., Ferrante, L., et al. (2023) Sur-face Coatings of Dental Implants: A Review. Journal of Functional Biomaterials, 14, Article No. 287. [Google Scholar] [CrossRef] [PubMed]
[33] Chiantella, G.C. (2016) Horizontal Guided Bone Regeneration in the Es-thetic Area with RhPDGF-BB and Anorganic Bovine Bone Graft: A Case Report. International Journal of Periodontics & Restorative Dentistry, 36, E9-E15. [Google Scholar] [CrossRef] [PubMed]
[34] Kao, R.T. and Lynch, S.E. (2011) Stability of Recombinant Human Plate-let-Derived Growth Factor-BB-Regenerated Periodontal Defects: Sixty-Month Clinical and Radiographic Observations. Clinical Advances in Periodontics, 1, 132-141. [Google Scholar] [CrossRef] [PubMed]
[35] Chang, P.C., Seol, Y.J., Cirelli, J.A., et al. (2010) PDGF-B Gene Therapy Accelerates Bone Engineering and Oral Implant Osseointegration. Gene Therapy, 17, 95-104. [Google Scholar] [CrossRef] [PubMed]
[36] Nantavisai, S., Pisitkun, T., Osathanon, T., et al. (2020) Systems Biology Analysis of Osteogenic Differentiation Behavior by Canine Mesenchymal Stem Cells De-rived from Bone Marrow and Dental Pulp. Scientific Reports, 10, Article No. 20703. [Google Scholar] [CrossRef] [PubMed]
[37] Beederman, M., Lamplot, J.D., Nan, G., et al. (2013) BMP Sig-naling in Mesenchymal Stem Cell Differentiation and Bone Formation. Journal of Biomedical Science and Engineering, 6, 32-52. [Google Scholar] [CrossRef] 
[38] Stiel, N., Hissnauer, T.N., Rupprecht, M., et al. (2016) Evaluation of Complications Associated with Off-Label Use of Recombinant Human Bone Morphogenetic Protein-2 (RhBMP-2) in Pediatric Orthopaedics. Journal of Materials Science: Materials in Medicine, 27, Article No. 184. [Google Scholar] [CrossRef] [PubMed]
[39] Kim, S.J., Shin, H.S. and Shin, S.W. (2010) Effect of Bone Block Graft with RhBMP-2 on Vertical Bone Augmentation. International Journal of Oral and Maxillofacial Surgery, 39, 883-888. [Google Scholar] [CrossRef] [PubMed]
[40] Shen, J., James, A.W., Zhang, X., et al. (2016) Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Mor-phogenetic Protein 2. The American Journal of Pathology, 186, 419-434. [Google Scholar] [CrossRef] [PubMed]
[41] Teng, F., Wei, L., Yu, D., et al. (2020) Vertical Bone Augmenta-tion with Simultaneous Implantation Using Deproteinized Bovine Bone Block Functionalized with a Slow Delivery of BMP-2. Clinical Oral Implants Research, 31, 215-228. [Google Scholar] [CrossRef] [PubMed]
[42] Zhang, Y., Hu, L., Lin, M., et al. (2021) RhBMP-2-Loaded PLGA/Titanium Nanotube Delivery System Synergistically Enhances Osseoin-tegration. ACS Omega, 6, 16364-16372. [Google Scholar] [CrossRef] [PubMed]
[43] Virk, M.S., Conduah, A., Park, S.H., et al. (2008) Influence of Short-Term Adenoviral Vector and Prolonged Lentiviral Vector Mediated Bone Morphogenetic Protein-2 Expression on the Quality of Bone Repair in a Rat Femoral Defect Model. Bone, 42, 921-931. [Google Scholar] [CrossRef] [PubMed]
[44] Kolk, A., Boskov, M., Haidari, S., et al. (2019) Comparative Analysis of Bone Regeneration Behavior Using Recombinant Human BMP-2 versus Plasmid DNA of BMP-2. Journal of Biomedical Materials Research Part A, 107, 163-173. [Google Scholar] [CrossRef] [PubMed]
[45] Kawase, T. (2015) Platelet-Rich Plasma and Its Derivatives as Promising Bioactive Materials for Regenerative Medicine: Basic Prin-ciples and Concepts Underlying Recent Advances. Odontology, 103, 126-135. [Google Scholar] [CrossRef] [PubMed]
[46] Attia, S., Narberhaus, C., Schaaf, H., et al. (2020) Long-Term In-fluence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Implant Survival and Success Rates. Journal of Clinical Medicine, 9, Article No. 391. [Google Scholar] [CrossRef] [PubMed]
[47] Huang, Y., Li, Z., Van Dessel, J., et al. (2019) Effect of Platelet-Rich Plasma on Peri-Implant Trabecular Bone Volume and Architecture: A Preclinical Micro-CT Study in Beagle Dogs. Clinical Oral Implants Research, 30, 1190-1199. [Google Scholar] [CrossRef] [PubMed]
[48] Al, S.A., Eimar, H., Abdallah, M.N., et al. (2015) Anti-VEGFs Hinder Bone Healing and Implant Osseointegration in Rat Tibiae. Journal of Clinical Periodontology, 42, 688-696. [Google Scholar] [CrossRef] [PubMed]
[49] Huang, B., Yao, Q., Huang, Y., et al. (2018) Combination Use of BMP2 and VEGF165 Promotes Osseointegration and Stability of Titanium Implants in Irradiated Bone. BioMed Research In-ternational, 2018, Article ID: 8139424. [Google Scholar] [CrossRef] [PubMed]
[50] Luo, T., Zhang, W., Shi, B., et al. (2012) Enhanced Bone Regeneration around Dental Implant with Bone Morphogenetic Protein 2 Gene and Vascular Endothelial Growth Factor Protein Deliv-ery. Clinical Oral Implants Research, 23, 467-473. [Google Scholar] [CrossRef] [PubMed]
[51] Jiang, J., Fan, C.Y. and Zeng, B.F. (2011) Experimental Construction of BMP2 and VEGF Gene Modified Tissue Engineering Bone in Vitro. International Journal of Molecular Sciences, 12, 1744-1755. [Google Scholar] [CrossRef] [PubMed]
[52] Schorn, L., Sproll, C., Ommerborn, M., et al. (2017) Vertical Bone Re-generation Using RhBMP-2 and VEGF. Head & Face Medicine, 13, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[53] Kim, H.Y., Park, J.H., Kim, M.J., et al. (2021) The Effects of VEGF-Centered Biomimetic Delivery of Growth Factors on Bone Regeneration. Biomaterials Science, 9, 3675-3691. [Google Scholar] [CrossRef] 
[54] Froum, S.J., Froum, S.H. and Rosen, P.S. (2015) A Regenerative Ap-proach to the Successful Treatment of Peri-Implantitis: A Consecutive Series of 170 Implants in 100 Patients with 2- to 10-Year Follow-Up. International Journal of Periodontics & Restorative Dentistry, 35, 857-863. [Google Scholar] [CrossRef] [PubMed]

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