代谢组学在创伤性颅脑损伤中的研究进展
Research Progress of Metabonomics in Traumatic Brain Injury
DOI: 10.12677/ACM.2024.143807, PDF,   
作者: 刘 智：济宁医学院临床医学院，山东 济宁；韩光魁*：济宁医学院附属医院神经外科监护室，山东 济宁
关键词: 代谢组学；生物标志物；创伤性颅脑损伤；综述；Metabonomics； Biomarkers； Traumatic Brain Injury； Review
摘要: 创伤性脑损伤(Traumatic Brain Injury, TBI)作为世界上最常见的后天性脑损伤，是世界上最主要的死亡和致残原因之一。由于多种原因的受伤因素以及大脑的复杂性，创伤性颅脑损伤可以诱导多种病理生理学机制的改变。因此早期的诊断以及良好的预后治疗TBI的迫切问题。代谢物作为生物体内的主要组成部分，参与了各种循环途径。代谢组学技术通过检测出不同代谢物浓度变化反应生物某一时间点生理、生化状态的准确信息。可以用来诊断疾病的严重程度、损伤机制、监测治疗反应及评估预后等。当前的代谢组学分析平台已能够检测和量化小浓度代谢物，使得我们评估颅脑损伤更加客观化、精细化。本文综述了代谢组学作为独立平台在临床环境中对于TBI的诊断、评估预后的前景。
Abstract: Traumatic brain injury (TBI), as the most common acquired brain injury in the world, is one of the most important causes of death and disability in the world. Due to various injury factors and the complexity of the brain, traumatic brain injury can induce changes in a variety of pathophysiologi-cal mechanisms. Therefore, early diagnosis and good prognosis are urgent problems in the treat-ment of TBI. As the main component of organism, metabolites participate in various circulation pathways. Metabonomics technology reflects the accurate information of biological physiological and biochemical state at a certain time point by detecting the changes of different metabolite con-centrations. It can be used to diagnose the severity, evolution, treatment and prognosis of the dis-ease. The current metabonomics analysis platform has been able to detect and quantify small con-centrations of metabolites, making our assessment of brain injury more objective and refined. This article reviews the prospect of metabonomics as an independent platform for evaluating TBI in clinical settings.
文章引用：刘智, 韩光魁. 代谢组学在创伤性颅脑损伤中的研究进展[J]. 临床医学进展, 2024, 14(3): 1042-1048. https://doi.org/10.12677/ACM.2024.143807

参考文献

[1] 张赛. 努力推进我国重型颅脑创伤的规范化救治[J]. 中华神经外科杂志, 2018, 34(2): 109-112.
[2] Scarboro, M. and Mcquillan, K.A. (2021) Traumatic Brain Injury Update. AACN Advanced Critical Care, 32, 29-50. [Google Scholar] [CrossRef] [PubMed]
[3] Jiang, J.Y., Gao, G.Y., Feng, J.F., et al. (2019) Traumatic Brain In-jury in China. The Lancet Neurology, 18, 286-295. [Google Scholar] [CrossRef] 
[4] Rees, P.M. (2003) Contemporary Issues in Mild Traumatic Brain Injury. Archives of Physical Medicine and Rehabilitation, 84, 1885-1894. [Google Scholar] [CrossRef] [PubMed]
[5] 陈鹏飞, 梁奕, 王剑. MSCT对颅脑损伤的早期诊断及其预后评估价值研究[J]. 中国CT和MRI杂志, 2021, 19(8): 22-24.
[6] Banoei, M.M., Lee, C.H., Hutchison, J., et al. (2023) Using Metabolomics to Predict Severe Traumatic Brain Injury Outcome (GOSE) at 3 and 12 Months. Critical Care (London, England), 27, Article No. 295. [Google Scholar] [CrossRef] [PubMed]
[7] Giordano, K.R., Rojas-Valencia, L.M., Bhargava, V., et al. (2020) Beyond Binary: Influence of Sex and Gender on Outcome after Traumatic Brain Injury. Journal of Neurotrauma, 37, 2454-2459. [Google Scholar] [CrossRef] [PubMed]
[8] Guijas, C., Montenegro-Burke, J.R., Warth, B., et al. (2018) Metabolomics Activity Screening for Identifying Metabolites That Modulate Phenotype. Nature Biotechnology, 36, 316-320. [Google Scholar] [CrossRef] [PubMed]
[9] Nicholson, J.K., Lindon, J.C. and Holmes, E. (1999) “Metabonom-ics”: Understanding the Metabolic Responses of Living Systems to Pathophysiological Stimuli via Multivariate Statistical Analysis of Biological NMR Spectroscopic Data. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 29, 1181-1189. [Google Scholar] [CrossRef] [PubMed]
[10] Hasanzad, M., Sarhangi, N., Ehsani Chimeh, S., et al. (2021) Pre-cision Medicine Journey through Omics Approach. Journal of Diabetes & Metabolic Disorders, 21, 881-888. [Google Scholar] [CrossRef] [PubMed]
[11] Tang, J. (2011) Microbial Metabolomics. Current Genomics, 12, 391-403. [Google Scholar] [CrossRef] [PubMed]
[12] Aldridge, B.B. and Rhee, KY. (2014) Microbial Metabolomics: Innovation, Application, Insight. Current Opinion in Microbiology, 19, 90-96. [Google Scholar] [CrossRef] [PubMed]
[13] Roberts, L.D., Souza, A.L., Gerszten, R.E., et al. (2012) Targeted Metabolomics. Current Protocols in Molecular Biology, 98, 30.2.1-30.2.24. [Google Scholar] [CrossRef] [PubMed]
[14] 纪勇, 郭盛磊, 杨玉焕. 代谢组学方法研究进展[J]. 安徽农业科学, 2015, 43(25): 21-23+48.
[15] Barkal, L.J., Theberge, A.B., Guo, C.J., et al. (2016) Microbial Metabolomics in Open Microscale Platforms. Nature Communications, 7, Article No. 10610. [Google Scholar] [CrossRef] [PubMed]
[16] Biedermann, M. and Grob, K. (2012) On-Line Coupled High Perfor-mance Liquid Chromatography-Gas Chromatography for the Analysis of Contamination by Mineral Oil. Part 2: Migra-tion from Paperboard into Dry Foods: Interpretation of Chromatograms. Journal of Chromatography A, 1255, 76-99. [Google Scholar] [CrossRef] [PubMed]
[17] Mikami, T., Aoki, M. and Kimura, T. (2012) The Application of Mass Spectrometry to Proteomics and Metabolomics in Biomarker Discovery and Drug Development. Current Molecu-lar Pharmacology, 5, 301-316. [Google Scholar] [CrossRef] [PubMed]
[18] Katz, L. and Baltz, R.H. (2016) Natural Product Discovery: Past, Present, and Future. Journal of Industrial Microbiology & Biotechnology, 43, 155-176. https://pubmed.ncbi.nlm.nih.gov/26739136/ [Google Scholar] [CrossRef] [PubMed]
[19] 汪明明, 程海婷, 薛明. 基于LC-MS的代谢组学分析流程与技术方法[J]. 国际药学研究杂志, 2011, 38(2): 130-136.
[20] Bhattrai, A., Irimia, A. and Van Horn, J.D. (2019) Neuroimaging of Traumatic Brain Injury in Military Personnel: An Overview. Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia, 70, 1-10. [Google Scholar] [CrossRef] [PubMed]
[21] Kochanek, P.M., Jackson, T.C., Ferguson, N.M., et al. (2015) Emerging Therapies in Traumatic Brain Injury. Seminars in Neurology, 35, 83-100. [Google Scholar] [CrossRef] [PubMed]
[22] Hergenroeder, G.W., Redell, J.B., Moore, A.N., et al. (2008) Bi-omarkers in the Clinical Diagnosis and Management of Traumatic Brain Injury. Molecular Diagnosis & Therapy, 12, 345-358. [Google Scholar] [CrossRef] 
[23] Kulbe, J.R. and Geddes, J.W. (2016) Current Status of Fluid Biomarkers in Mild Traumatic Brain Injury. Experimental Neurology, 275, 334-352. [Google Scholar] [CrossRef] [PubMed]
[24] 王增亮. 脑挫伤大鼠GFAP、ApoE、S-100、炎症因子时序性表达及代谢组学研究[D]: [博士学位论文]. 乌鲁木齐: 新疆医科大学, 2015.
[25] Yokobori, S., Hosein, K., Burks, S., et al. (2013) Biomarkers for the Clinical Differential Diagnosis in Traumatic Brain Injury—A Systematic Re-view. CNS Neuroscience & Therapeutics, 19, 556-565. [Google Scholar] [CrossRef] [PubMed]
[26] Marino, S., Zei, E., Battaglini, M., et al. (2007) Acute Metabolic Brain Changes Following Traumatic Brain Injury and Their Relevance to Clinical Severity and Outcome. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 501-507. [Google Scholar] [CrossRef] [PubMed]
[27] Zheng, F., Zhou, Y.T., Feng, D.D., Li, P.F., Tang, T., Luo, J.K. and Wang, Y. (2020) Metabolomics Analysis of the Hippocampus in a Rat Model of Traumatic Brain Injury during the Acute Phase. Brain and Behavior, 10, E01520. [Google Scholar] [CrossRef] [PubMed]
[28] Dash, P.K., Zhao, J., Hergenroeder, G., et al. (2010) Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury. Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics, 7, 100-114. [Google Scholar] [CrossRef] [PubMed]
[29] Wolahan, S.M., Hirt, D., Braas, D., et al. (2016) Role of Metabo-lomics in Traumatic Brain Injury Research. Neurosurgery Clinics of North America, 27, 465-472. [Google Scholar] [CrossRef] [PubMed]
[30] Orešič, M., Posti, J.P., Kamstrup-Nielsen, M.H., et al. (2016) Hu-man Serum Metabolites Associate with Severity and Patient Outcomes in Traumatic Brain Injury. EBioMedicine, 12, 118-126. [Google Scholar] [CrossRef] [PubMed]
[31] Jeter, C.B., Hergenroeder, G.W., Ward, N.H., et al. (2013) Human Mild Traumatic Brain Injury Decreases Circulating Branched-Chain Amino Acids and Their Metabolite Levels. Journal of Neurotrauma, 30, 671-679. [Google Scholar] [CrossRef] [PubMed]
[32] Dumas, M.E. and Davidovic, L. (2015) Metabolic Profiling and Phe-notyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions. Journal of Neuro-immune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology, 10, 402-424. [Google Scholar] [CrossRef] [PubMed]
[33] Barkhoudarian, G., Hovda, D.A. and Giza, C.C. (2016) The Mo-lecular Pathophysiology of Concussive Brain Injury—An Update. Physical Medicine and Rehabilitation Clinics of North America, 27, 373-393. [Google Scholar] [CrossRef] [PubMed]
[34] Yi, L., Shi, S., Wang, Y., et al. (2016) Serum Metabolic Profiling Reveals Altered Metabolic Pathways in Patients with Post-Traumatic Cognitive Impairments. Scientific Reports, 6, Article No. 21320. [Google Scholar] [CrossRef] [PubMed]
[35] 吕柳. 基于超高效液相色谱-高分辨质谱联用技术的颅脑损伤大鼠代谢组学相关性研究[D]: [硕士学位论文]. 郑州: 郑州大学, 2019.
[36] Zheng, F., Xia, Z.A., Zeng, Y.F., et al. (2017) Plasma Metabolomics Profiles in Rats with Acute Traumatic Brain Injury. PLOS ONE, 12, E0182025. [Google Scholar] [CrossRef] [PubMed]
[37] Zhang, G., Lang, Z., Yang, Q., et al. (2021) UPLC-Q-TOF/MS-Based Plasma Metabolome to Identify Biomarkers and Time of Injury in Traumatic Brain Injured Rats. Neuroreport, 32, 415-422. [Google Scholar] [CrossRef] 
[38] Viant, M.R., Lyeth, B.G., Miller, M.G., et al. (2005) An NMR Metabolomic Investigation of Early Metabolic Disturbances Following Traumatic Brain Injury in a Mammalian Model. NMR in Biomedicine, 18, 507-516. [Google Scholar] [CrossRef] [PubMed]
[39] Shan, R., Szmydynger-Chodobska, J., Warren, O.U., et al. (2016) A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults. Journal of Neuro-trauma, 33, 49-57. [Google Scholar] [CrossRef] [PubMed]

为你推荐