血浆肝素结合蛋白、降钙素原、白介素-6在新生儿细菌性感染早期诊断中的应用价值研究

Application Value of Plasma Heparin-Binding Protein, Procalcitonin and Interleukin-6 in Early Diagnosis of Neonatal Bacterial Infection

摘要: 目的：探讨血浆肝素结合蛋白(HBP)、降钙素原(PCT)、白介素-6 (IL-6)在新生儿细菌性感染早期诊断中的诊断价值。方法：收集2022年10月至2023年9月安徽医科大学附属巢湖医院新生儿病房收治的细菌感染新生儿81例作为研究组，另外选取单纯性高胆红素血症的新生儿78例作为对照组。在清晨相对空腹时抽取静脉血，以免疫荧光干式定量法检测HBP水平，以电化学发光免疫分析仪检测PCT及IL-6水平。通过对两组儿童血清HBP，PCT，IL-6水平进行分析，并对其进行统计学分析，并采用工作特性曲线对各感染指标进行独立测定和三种方法联合测定对新生儿细菌感染的诊断价值。结果：感染组患儿血清HBP、PCT、IL-6水平较非感染组明显升高(P < 0.05)。结果分析显示HBP、PCT、IL-6诊断新生儿早期细菌感染的曲线下面积(AUC)分别为0.916、0.723、0.770，三者联合检测的曲线下面积(AUC)为0.936。结论：HBP对于早期诊断新生儿细菌性感染具有较高的临床价值，三者联合检测诊断价值更高，更有利于及时治疗。

Abstract: Objective: To investigate the diagnostic value of plasma heparin-binding protein (HBP), procal-citonin (PCT) and interleukin-6 (IL-6) in the early diagnosis of neonatal bacterial infection. Methods: A total of 81 cases of neonatal bacterial infection admitted to the Department of Neo-natology, Chaohu Hospital of Anhui Medical University from October 2022 to September 2023 were selected as the study group, and 78 cases of neonatal with simple hyperbilirubinemia were selected as the control group (non-infected group). Venous blood was taken on an empty stomach in the early morning, and HBP levels were detected by immunofluorescence dry quan-tification, and PCT and IL-6 levels were detected by electrochemical luminescence immunoana-lyzer. Comparison of HBP, PCT, and IL-6 in plasma was carried out. The detection results were statistically recorded and the diagnostic efficacy of individual and combined detection of each index in neonatal bacterial infection was evaluated by receiver operating characteristic (ROC) curve. Results: ROC curve analysis showed that the area under the curve (AUC) of HBP, PCT and IL-6 in the diagnosis of early neonatal bacterial infection were 0.916, 0.723 and 0.770, respec-tively, and the AUC of the combined detection of the three was 0.936. Conclusion: HBP has high clinical value in early diagnosis of neonatal bacterial infection, and the combined detection of HBP has higher diagnostic value and is more conducive to timely treatment.