全息血管硬度分析技术评价2型糖尿病患者颈总动脉弹性改变的价值

Value of RF-Data Based Quantitative Analysis on Vessel Stiffness in Evaluating Common Carotid Artery Elasticity Changes of Type 2 Diabetic Subjects

摘要: 目的：应用全息血管硬度分析技术(R-VQS)评价2型糖尿病(T2DM)患者颈总动脉弹性的变化及其与糖化血红蛋白(HbA1c)的相关性。方法：选取2023年2月至2024年1月于我院内分泌科住院的T2DM患者61例，按照HbA1c水平分为HbA1c < 7%控制良好组30例及HbA1c ≥ 7%控制不良组31例；选取同期34名健康体检者为正常对照组(NC)。应用R-VQS技术测量颈总动脉收缩期管径(Diam)、管径变化值(Dist)、脉搏波传导速度(PWV)和硬度系数(HC)，分析各组颈总动脉各弹性参数的改变及其与HbA1c的相关性。结果：与NC组相比，HbA1c < 7%控制良好组的Diam、Dist、PWV和HC值均差异不显著(P > 0.05)；HbA1c ≥ 7%控制不良组的Diam、Dist差异不显著(P > 0.05)，而PWV、HC显著升高(P < 0.05)。与HbA1c < 7%控制良好组相比，HbA1c ≥ 7%控制不良组的Diam、Dist差异不显著(P > 0.05)，PWV、HC同样显著升高(P < 0.05)。Pearson相关性分析结果显示，HbA1c与PWV、HC呈正相关(P < 0.01)。结论：T2DM血糖控制不良患者，颈总动脉PWV、HC升高，说明其颈总动脉弹性受损，血管硬度增加。

Abstract: Objective: To evaluate the changes of carotid artery elasticity in type 2 diabetic subjects with poor glucose control and its correlation with glycosylated hemoglobin (HbA1c). Methods: A total of 61 pa-tients with type 2 diabetes mellitus and 34 control subjects were recruited in this study. The T2DM group was further divided into HbA1c < 7% group and HbA1c ≥ 7% group according to the HbA1c level. The diameter, distance, pulse wave velocity and hardness coefficient of common carotid artery systole were evaluated by R-VQS. The correlation between carotid artery elasticity and HbA1c was analyzed by Pearson correlation analysis. Results: Diam, Dist, PWV, HC had no significant difference in HbA1c < 7% group compared with control group (P > 0.05). Diam, Dist had no significant differ-ence in HbA1c ≥ 7% group compared with control group (P > 0.05). PWV, HC increased in HbA1c ≥ 7% group compared with control group (P < 0.05). Diam, Dist had no significant difference in HbA1c ≥ 7% group compared with HbA1c < 7% group (P > 0.05). PWV, HC and HbA1c increased in HbA1c ≥ 7% group than in HbA1c < 7% (P < 0.05). Pearson correlation analysis showed that PWV and HC were positively correlated with HbA1c (P < 0.01). Conclusion: The increased PWV and HC in type 2 diabet-ic subjects with poor blood glucose control may indicate that the elasticity of CCA is impaired and the stiffness of blood vessel is increased.