HIF-1α在感染性疾病中相关机制的研究进展
Research Progress on the Mechanisms of HIF-1α in Infectious Diseases
DOI: 10.12677/ACM.2024.143827, PDF,  被引量    科研立项经费支持
作者: 阿 慧*:大理大学临床医学院,云南 大理;严桥路#:大理白族自治州人民医院呼吸与危重症医学科,云南 大理;何连福:大理大学第一附属医院呼吸与危重症医学科,云南 大理
关键词: HIF-1α感染宿主免疫代谢调节感染防御 HIF-1α Infection Host Immunity Metabolic Regulation Infection Defense
摘要: 本文综述了缺氧诱导因子1α (HIF-1α)在感染和宿主免疫反应中的多方面作用。包括HIF-1α在宿主免疫反应和感染防御中的作用、在抗感染中炎症因子的诱导、免疫代谢调节,及其在炎症、氧化应激细胞凋亡、糖酵解代谢途径中作用等。通过综述更好地理解HIF-1α在感染性疾病中的重要作用。为进一步深入研究提供依据。
Abstract: This article reviews the multifaceted roles of hypoxia-inducible factor 1α (HIF-1α) in infection and host immune responses. This includes the role of HIF-1α in host immune response and infection de-fence, induction of inflammatory factors in anti-infection, regulation of immune metabolism, and its role in inflammation, oxidative stress apoptosis, and glycolytic metabolic pathways. The review provides a better understanding of the important role of HIF-1α in infectious diseases. It provides a basis for further in-depth research.
文章引用:阿慧, 严桥路, 何连福. HIF-1α在感染性疾病中相关机制的研究进展[J]. 临床医学进展, 2024, 14(3): 1184-1191. https://doi.org/10.12677/ACM.2024.143827

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